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TBK1 as a regulator of autoimmunity and antitumor immunity

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References

  1. Hiscott J. Triggering the innate antiviral response through IRF-3 activation. J Biol Chem 2007; 282: 15325–15329.

    Article  CAS  Google Scholar 

  2. Hu H, Sun SC. Ubiquitin signaling in immune responses. Cell Res 2016; 26: 457–483.

    Article  CAS  Google Scholar 

  3. Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H et al. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med 2004; 199: 1641–1650.

    Article  CAS  Google Scholar 

  4. Perry AK, Chow EK, Goodnough JB, Yeh WC, Cheng G. Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med 2004; 199: 1651–1658.

    Article  CAS  Google Scholar 

  5. Clément JF, Meloche S, Servant MJ. The IKK-related kinases: from innate immunity to oncogenesis. Cell Res 2008; 18: 889–899.

    Article  Google Scholar 

  6. ** J, **ao Y, Chang JH, Yu J, Hu H, Starr R et al. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-kappaB signaling. Nat Immunol 2012; 13: 1101–1109.

    Article  CAS  Google Scholar 

  7. Yu J, Zhou X, Chang M, Nakaya M, Chang JH, **ao Y et al. Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nat Commun 2015; 6: 6074.

    Article  CAS  Google Scholar 

  8. Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W et al. IkappaB Kinase epsilon Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell reports 2016; 16: 405–418.

    Article  CAS  Google Scholar 

  9. Oakes JA, Davies MC, Collins MO. TBK1: a new player in ALS linking autophagy and neuroinflammation. Mol Brain 2017; 10: 5.

    Article  Google Scholar 

  10. **ao Y, Zou Q, **e X, Liu T, Li HS, Jie Z et al. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med 2017; 214: 1493–1507.

    Article  CAS  Google Scholar 

  11. Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov 2017; 8: 196–215.

    Article  Google Scholar 

  12. Bonnard M, Mirtsos C, Suzuki S, Graham K, Juang J, Ng M et al. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kB-dependent gene transcription. EMBO J 2000; 19: 4976–4985.

    Article  CAS  Google Scholar 

  13. Clark K, Plater L, Peggie M, Cohen P. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J Biol Chem 2009; 284: 14136–14146.

    Article  CAS  Google Scholar 

  14. Liu S, Cai X, Wu J, Cong Q, Chen X, Li T et al. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 2015; 347: aaa2630.

    Article  Google Scholar 

  15. Chang JH, Hu H, Sun SC. Survival and maintenance of regulatory T cells require the kinase TAK1. Cell Mol Immunol 2015; 12: 572–579.

    Article  CAS  Google Scholar 

  16. Hammer GE, Ma A. Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol 2013; 31: 743–791.

    Article  CAS  Google Scholar 

  17. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21: 685–711.

    Article  CAS  Google Scholar 

  18. Mahnke K, Schmitt E, Bonifaz L, Enk AH, Jonuleit H. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol 2002; 80: 477–483.

    Article  Google Scholar 

  19. Simmons SB, Pierson ER, Lee SY, Goverman JM. Modeling the heterogeneity of multiple sclerosis in animals. Trends Immunol 2013; 34: 410–422.

    Article  CAS  Google Scholar 

  20. Sharma P, Wagner K, Wolchok JD, Allison JP. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat Rev Cancer 2011; 11: 805–812.

    Article  CAS  Google Scholar 

  21. Maueroder C, Munoz LE, Chaurio RA, Herrmann M, Schett G, Berens C. Tumor Immunotherapy: Lessons from Autoimmunity. Front Immunol 2014; 5: 212.

    PubMed  Google Scholar 

  22. Schiavoni G, Mattei F, Gabriele L. Type I Interferons as Stimulators of DC-Mediated Cross-Priming: Impact on Anti-Tumor Response. Frontiers in immunology 2013; 4: 483.

    Article  Google Scholar 

  23. Wang WB, Levy DE, Lee CK. STAT3 negatively regulates type I IFN-mediated antiviral response. J Immunol 2011; 187: 2578–2585.

    Article  CAS  Google Scholar 

  24. Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nat Rev Immunol 2014; 14: 36–49.

    Article  CAS  Google Scholar 

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Acknowledgements

Work in the authors’ laboratory is supported by grants from the US National Institutes of Health (AI057555, AI064639, GM84459, and AI104519) and the Cancer Prevention and Research Institute of Texas (RP150235).

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    Correspondence to Shao-Cong Sun.

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    Shi, JH., **e, X. & Sun, SC. TBK1 as a regulator of autoimmunity and antitumor immunity. Cell Mol Immunol 15, 743–745 (2018). https://doi.org/10.1038/cmi.2017.165

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