Abstract
To study the possible involvement of mouse mammary tumour virus (MMTV) related agent in human cancer we analysed 300 samples of human sera for the presence of antibodies to MMTV structural proteins. All sera were tested by immunoblotting to achieve high specificity. Out of 300 sera, 22 reacted with transframe protein p30, 16 with the ribonucleoprotein p14, six with the envelope glycoprotein gp52 and three with the major core protein p27. Reactivities to p30 and p14 were observed in sera from cancer patients and healthy controls; reactivities to p27 and gp52 predominated in sera of cancer patients. Sera frequently reacted with a 42 kDa protein which is a cellular contaminant of the virus.
Article PDF
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kovařík, A., Hlubinová, K., Prachař, J. et al. No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer. Br J Cancer 60, 572–575 (1989). https://doi.org/10.1038/bjc.1989.315
Issue Date:
DOI: https://doi.org/10.1038/bjc.1989.315
- Springer Nature Limited
This article is cited by
-
Evidence for a causal role by mouse mammary tumour-like virus in human breast cancer
npj Breast Cancer (2019)
-
Prevalence of serologic reactivity against four strains of mouse mammary tumour virus among US women with breast cancer
British Journal of Cancer (2006)
-
A new 85 kDa, breast tumour associated antigen — A potential diagnostic and prognostic agent
Journal of Biosciences (1997)
-
Immunological quantification of recA protein in cell extracts ofE. coli after exposure to chemical mutagens or UV radiation
Folia Microbiologica (1992)