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Carcinogenic Activity of N-Methyl-N-nitroso-N′-nitroguanidine

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Abstract

N-METHYL-N-NITROSOURETHANE (MNU) (I) and its ethyl homologue have been found to be effective carcinogens, which can induce stomach, oesophageal, intestinal and lung tumours with one or a few doses1–6. As urethane itself is carcinogenic it seemed of interest to test the related N-alkyl-N-nitroso-N′-nitroguanidines, in order to assess the role of the ethoxycarbonyl-group in the carcinogenic action.

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Authors and Affiliations

  1. Toxicology Research Unit, Medical Research Council Laboratories, Carshalton, Surrey

    R. SCHOENTAL

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  1. R. SCHOENTAL
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SCHOENTAL, R. Carcinogenic Activity of N-Methyl-N-nitroso-N′-nitroguanidine. Nature 209, 726–727 (1966). https://doi.org/10.1038/209726a0

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