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Breakdown of Polyvalent Tolerance in the Chicken by Thymic Grafts

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Abstract

POLYVALENT immunological tolerance of varying degrees to histocompatibility antigens can be induced in non-inbred recipients by the neonatal injection of pooled cells from a wide range of donors. This was demon strated by Hasek and Haskova1 in ducks, Koldovsky2 and Billingham and Silvers3 in rats, and by Lengerova4 in mice. All these workers used the acceptance of skin homografts as the criterion of tolerance.

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Authors and Affiliations

  1. Walter and Eliza Hall Institute of Medical Research, Melbourne

    A. SZENBERG & N. L. WARNER

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  1. A. SZENBERG
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  2. N. L. WARNER
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SZENBERG, A., WARNER, N. Breakdown of Polyvalent Tolerance in the Chicken by Thymic Grafts. Nature 198, 1012–1013 (1963). https://doi.org/10.1038/1981012a0

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