Abstract
WE have examined a streptomycin-producing strain of Streptomyces griseus 1 and two mutants derived from it which did not produce streptomycin. The two mutants arose by treatment with mustard nitrogen2. They were isolated as a single colony by the method previously described3. Out of 1,387 Streptomyces griseus colonies grown from single spores after treatment with mustard nitrogen there appeared 33 non-producing colonies. Only two of them remained stable non-producers after being transferred several times. Their cultural and physiological characteristics differed from the parent strain.
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SZABÓ, G., VÁLYI-NAGY, T., BARABÁS, G. et al. Comaprison of Strains of Streptomyces griseus which produce Streptomycin and those which do not. Nature 188, 428 (1960). https://doi.org/10.1038/188428a0
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DOI: https://doi.org/10.1038/188428a0
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