Abstract
THE transformation of inactive or slightly active compounds into effective carcinogens by O-methylation has been discussed previously1, and it was suggested that endogenous carcinogens may possibly be formed by alkylation of normal cell constituents in the body. Such a mechanism could account also for the carcinogenic effects of radiation and of remotely acting agents, such as the azo-dyes, ethionine, etc., which may give rise to alkyl radicals in the body.
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References
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SCHOENTAL, R. Carcinogenic Action of Diazomethane and of Nitroso-N-methyl Urethane. Nature 188, 420–421 (1960). https://doi.org/10.1038/188420b0
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DOI: https://doi.org/10.1038/188420b0
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