Abstract
BY fractionation of coal-tar on alumina, Berenblum and Schoental1 demonstrated that the fraction preceding and that following the one containing 3 : 4-benzpyrene were carcinogenic to rodents though free from spectrographically detectable amounts of 3 : 4-benzpyrene. Fractional crystallization of picrates from the fraction following the one containing 3 : 4-benzpyrene gave, among others, reddish-brown needles melting at 160–189° C. These picrates were decomposed by chromatography on alumina, and after repeated crystallizations from various solvents yielded yellow glistening scales, melting with some softening at 280° C.
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References
Berenblum, I., and Schoental, R., Brit. J. Cancer, 1, 157 (1947).
Scholl, R., and Neumann, H., Ber. Deutsch. Chem. Ges., 55, 123 (1922).
Clar, E., Ber. Deutsch. Chem. Ges., 72, 1645 (1939).
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SCHOENTAL, R. Isolation of 3 : 4-9 : 10-Dibenzopyrene from Coal-Tar. Nature 180, 606 (1957). https://doi.org/10.1038/180606a0
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DOI: https://doi.org/10.1038/180606a0
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