Abstract
THE work of Gale1 points to the possibility that penicillin may act by depriving sensitive organisms of glutamic acid, which is probably essential to their life. The present work was instituted to find out whether penicillin, by being itself adsorbed, blocks the passage of glutamic acid through the cell wall.
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References
Gale, E. F., and Taylor, E. S., J. Gen. Microbiol., 1, 314 (1947).
Hobby, G. L., Meyer, K., and Chaffee, E., Proc. Soc. Exp. Biol., N.Y., 50, 281 (1942).
Jarvis, F. G., and Johnson, M. J., J. Amer. Chem. Soc., 69, 3010 (1947).
Lester-Smith, E., Quart. J. Pharm., 19, 309 (1946).
Howell, S. F., Thayer, J. D., and Labow, L. W., Science, 107, 299 (1948).
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ROWLEY, D., MILLER, J., ROWLANDS, S. et al. Studies with Radioactive Penicillin. Nature 161, 1009–1010 (1948). https://doi.org/10.1038/1611009a0
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DOI: https://doi.org/10.1038/1611009a0
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