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Metabolic Products of 3: 4-Benzpyrene

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Abstract

IN 1936, Peacock1 observed that animals receiving intravenous injections of 3: 4-benzpyrene excreted in the bile an alkali-soluble product (BPX) possessing specific fluorescence bands which differed from those of the parent hydrocarbon. Subsequent investigations by Chalmers2,3 demonstrated the existence of a similar phenolic derivative in the fæces, and this led to its isolation and purification. From recent crystallographic analysis4, this metabolic product is considered to be a monohydroxy-benzpyrene.

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References

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Authors and Affiliations

  1. Oxford University Research Centre of the British Empire Cancer Campaign, Sir William Dunn School of Pathology, University of Oxford,

    I. BERENBLUM & R. SCHOENTAL

Authors
  1. I. BERENBLUM
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  2. R. SCHOENTAL
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BERENBLUM, I., SCHOENTAL, R. Metabolic Products of 3: 4-Benzpyrene. Nature 149, 439–440 (1942). https://doi.org/10.1038/149439b0

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