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Nitric Oxide Storage in the Cardiovascular System

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Abstract

Nitric oxide (NO) is a highly reactive substance with short lifetime. In conditions of a living organism NO can be bound by the complexes used for transport and intracellular storage of NO. The main biological forms of NO store include S-nitrosothiols and dinitrosyl iron complexes capable of interconversion. The NO store formed by these complexes in the vascular wall, on the one hand, provides for protection from excessive free NO after its overproduction and, on the other hand, can be an additional NO source when it is deficient. Apparently, the efficiency of NO storage is genetically determined and corresponds to the inherited level of NO production in the organism. Controlled modulation of formation and dissociation of the NO store is a promising trend for further investigation.

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Authors and Affiliations

  1. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia

    E. B. Manukhina, B. V. Smirin & I. Yu. Malyshev

  2. Louis Pasteur University, CNRS UMR 7034, Strasbourg, France

    J.-C. Stoclet & B. Muller

  3. Vitebsk State Medical University, pr. Frunze 27, Vitebsk, 210602, Belarus

    A. P. Solodkov & V. I. Shebeko

  4. Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia

    A. F. Vanin

Authors
  1. E. B. Manukhina
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  2. B. V. Smirin
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  3. I. Yu. Malyshev
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  4. J.-C. Stoclet
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  5. B. Muller
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  6. A. P. Solodkov
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  7. V. I. Shebeko
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  8. A. F. Vanin
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Manukhina, E.B., Smirin, B.V., Malyshev, I.Y. et al. Nitric Oxide Storage in the Cardiovascular System. Biology Bulletin 29, 477–486 (2002). https://doi.org/10.1023/A:1020465810586

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