Abstract
We studied the ability of stromal sublayer of long-term bone marrow cultures and peripheral blood macrophages from patients with various forms of myelodysplastic syndrome to maintain the growth of normal granulocyte-macrophage colony-forming units in mixed cultures. There were changes in the hemopoietic microenvironment in these patients: decreased cellularity of the bone marrow and impaired formation of sublayers in long-term bone marrow cultures, production of growth factors, maintaining the growth of normal granulocyte-macrophage precursors by stromal cells. Dysfunction of macrophages in the stromal microenvironment was probably related to the presence of pathological macrophages.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 255–258, September, 2000
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Manakova, T.E., Gerasimova, L.P., Tsvetaeva, N.V. et al. Functional disturbances in hemopoietic microenvironment in various forms of myelodysplastic syndrome. Bull Exp Biol Med 130, 832–834 (2000). https://doi.org/10.1023/A:1015341623554
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DOI: https://doi.org/10.1023/A:1015341623554