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Glutathione-S-Transferase M1 Null Genotype in Autoimmune Hepatitis

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Abstract

Autoimmune hepatitis is associated with genes located in the major histocompatibility complex. The search for genes at other loci that may play a role in disease susceptibility and/or severity is an area of active investigation in autoimmune liver diseases. Genes for glutathione-S-transferases, enzymes that are widely distributed and collectively metabolize carcinogens, pollutants, drugs, and a broad spectrum of harmful, foreign compounds have been associated with liver disease. The objective of this study was to search for a relationship between the glutathione-S-transferase M1 null genotype and autoimmune hepatitis using polymerase chain reaction analysis. The findings indicate that the frequency of the null genotype is not increased in patients with autoimmune hepatitis when compared to control subjects. These results coupled with similar ones in primary biliary cirrhosis do not support a role for this mutation in autoimmune liver disease.

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REFERENCES

  1. Krawitt EL: Medical progress: Autoimmune hepatitis. N Eng J Med 334:897–903, 1996

    Google Scholar 

  2. Donaldson P, Albertini RJ, Krawitt EL: Immunogenetic studies of autoimmune hepatitis and primary sclerosing cholangitis. In Autoimmune Liver Diseases. EL Krawitt, RS Wiesner, M. Nishioka (Eds.). Amsterdam, Elsevier, 1998, pp 141–166

    Google Scholar 

  3. Agarwal K, Jones DEJ, Daly AK, James OFW, Vaidya B, Pearce S, Bassendine MF: CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis. J Hepatol 32: 538–541, 2000

    Google Scholar 

  4. Cookson S, Constantini PK, Clare M, Underhill JA, Bernal W, Czaja AJ, Donaldson PT: Frequency and nature of cytokine gene polymorphisms in type 1 autoimmune hepatitis. Hepatology 30:851–856, 1999

    Google Scholar 

  5. Donaldson PT, Norris S, Constantini PK, Bernal W, Harrison P, Williams R: The interleukin-1 and interleukin-10 gene polymorphisms in primary sclerosing cholangitis: No associations with disease susceptibility/resistance. J Hepatol 32:882–886, 2000

    Google Scholar 

  6. Mannervik B, Awasthi YC, Board PG, Hayes JD, Di Ilio C, Ketterer B, Listowsky I, Morgenstern R, Muramatsu M, Pearson WR, Pickett CB, Sato K, Widersten M, Wolf CR: Nomenclature for human glutathione transferases. Biochem J 282:305–308, 1992

    Google Scholar 

  7. DeJong JL, Mohandas T, Tu CP: The human Hb (mu) class gluthatione S-transferases are encoded by a dispersed gene family. Biochem Biophys Res Commun 180:15–22, 1991

    Google Scholar 

  8. Pearson WR, Vorachek WR, Xu S, Berger R, Hart I, Vannais D, Patterson D: Identification of class-mu glutathione transferase gene GSTM1-GSTM5 on human chromosome 1p13. Am J Hum Genet 53:220–223, 1993

    Google Scholar 

  9. Zhang H, Ahmadi A, Arbman G, Zdolsek J, Carstensen J, Nordenskjold B, Soderkvist P, Sun XF: Glutathione Stransferase T1 and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma. Int J Cancer 84:135–138, 1999

    Google Scholar 

  10. Strange RC, Lear JT, Fryer AA: Glutathione S-transferase polymorphisms: Influence, on susceptibility to cancer. Chem-Biol Interact 111-112:364, 1998

    Google Scholar 

  11. Davies MH, Elias E, Acharya S, Cotton W, Faulder GC, Fryer AA, Strange RC: GSTM1 null polymorphism at the glutathione S-transferase M1 locus: Phenotype and genotype studies in patients with primary biliary cirrhosis. Gut 34:549–553, 1993

    Google Scholar 

  12. Savolainen VT, Pjarinen J, Perola M, Penttila A, Karhunen PJ: Glutathione-S-transferase GST M1 “null” genotype and the risk of alcoholic liver disease. Alcohol Clin Exp Res 20: 1340–1345, 1996

    Google Scholar 

  13. Chen CJ, Yu MW, Liaw YF, Wang LW, Chiamprasert S, Matin F, Hirvonen A, Bell DA, Santella RM: Chronic hepatitis B carriers with null genotypes of glutathione-S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. Am J Hum Genet 59:128–134, 1996

    Google Scholar 

  14. Harada, S, Abei, M, Tanaka, N, Agarwal, DP, Goedde, HW: Liver glutathione S-transferase polymorphism in Japanese and its pharmacogenetic importance. Hum Genet 75:322–325, 1987

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA

    Naomi K. Fukagawa, ** Liang, Muyao Li, Takamaru Ashikaga & Edward L. Krawitt

  2. Center for Liver Disease, University of Miami School of Medicine, Miami, Florida

    K. Rajender Reddy

Authors
  1. Naomi K. Fukagawa
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  2. ** Liang
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  3. Muyao Li
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  4. Takamaru Ashikaga
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  5. K. Rajender Reddy
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  6. Edward L. Krawitt
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Fukagawa, N.K., Liang, P., Li, M. et al. Glutathione-S-Transferase M1 Null Genotype in Autoimmune Hepatitis. Dig Dis Sci 46, 2080–2083 (2001). https://doi.org/10.1023/A:1011930008011

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