Abstract
Imaging-derived phenotypes (IDPs) have been increasingly used in population-based cohort studies in recent years. As widely reported, magnetic resonance imaging (MRI) is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast. The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project (CHPP). Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP. The brain imaging sequences included T1-magnetization that prepared rapid gradient echo, T2 fluid-attenuated inversion-recovery, magnetic resonance angiography, diffusion MRI, and resting-state functional MRI. The detailed descriptions of image acquisition, interpretation, and post-processing were provided in this article. The measured IDPs included volumes of brain subregions, cerebral vessel geometrical parameters, microstructural tracts, and function connectivity metrics.
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Data availability
The data supported the protocols of this study are available on request from the corresponding author.
Abbreviations
- AAL:
-
Automated anatomical labeling
- AD:
-
Axial diffusivity
- ADC:
-
Apparent diffusion coefficient
- ALFF:
-
Amplitude of low-frequency fluctuation
- CAT:
-
Computational anatomy toolbox
- CHPP:
-
China Phenobank Project
- CSF:
-
Cerebrospinal fluid
- DC:
-
Degree centrality
- DWI:
-
Diffusion weighted imaging
- DTI:
-
Diffusion tensor imaging
- EPI:
-
Echo-echo planar imaging
- FA:
-
Fractional anisotropy
- FC:
-
Functional connectivity
- FLAIR:
-
Fluid-attenuated inversion-recovery
- GRE:
-
Gradient recalled echo
- IDP:
-
Imaging-derived phenotype
- MD:
-
Mean diffusivity
- MPRAGE:
-
Magnetization prepared rapid gradient echo
- MRI:
-
Magnetic resonance imaging
- RD:
-
Radial diffusivity
- ReHo:
-
Regional homogeneity
- rfMRI:
-
Resting-state functional magnetic resonance imaging
- ROI:
-
Region of interest
- SAG:
-
Sagittal
- SE-EPI:
-
Spin echo-echo planar imaging
- T 1w:
-
T1-Weighted
- T 2-FLAIR:
-
T2-Weighted fluid attenuated inversion recovery
- TBSS:
-
Tract‑based spatial statistics
- TOF-MRA:
-
Time of flight-magnetic resonance angiography
- TRA:
-
Transverse
- TSE:
-
Turbo spin echo
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Acknowledgements
The data and samples used for this protocol were obtained from CHPP. We would like to thank the CHPP participants and coordinators for their contribution to this dataset.
Funding
This study was funded by the Shanghai Municipal Science and Technology Major Project (No. 2017SHZDZX01).
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CW, MT, HW: concept and design, data interpretation and analysis, supervision, drafting, revision and approval of final manuscript. ZS, YL, NH, YG, WC, JZ, JL: data interpretation and analysis, drafting, revision and approval of final manuscript. XX, XK, SQ, LX, LL, YW, NZ, JT, XH, WC: data collection, data analysis, drafting, revision and approval of final manuscript.
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The study was in agreement with the ethical guidelines of the 1975 Declaration of Helsinki and approved by the institutional review board of Fudan University. Informed consent was obtained from each subject.
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MT is the Editorial Board Member of Phenomics, and she was not involved in reviewing this paper.
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Wang, C., Shi, Z., Li, Y. et al. Protocol for Brain Magnetic Resonance Imaging and Extraction of Imaging-Derived Phenotypes from the China Phenobank Project. Phenomics 3, 642–656 (2023). https://doi.org/10.1007/s43657-022-00083-w
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DOI: https://doi.org/10.1007/s43657-022-00083-w