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GOLDIC Therapy Holds Promise as an Orthobiologic Agent: A Systematic Review of the Literature

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Abstract

Introduction

Orthobiologic agents play a significant role in regenerative medicine. The quest for newer and more effective Orthobiologic agents is never-ending, leading to the evolution of more reformed products. GOLDIC (GOLD Induced cytokine) is a recently evolving Orthobiologic agent developed by conditioning autologous serum with gold particles. We aim to collate the available evidence on GOLDIC and provide a systematic literature review.

Materials and methods

Using Cochrane and PRISMA guidelines literature search was done for GOLDIC. After duplicate removal and exclusions, 62 articles were scrutinized, of which 8 articles qualified for full-text review. A risk-of-bias assessment of the included studies was done.

Results

All articles showed standardized preparation methods of GOLDIC and uniformity in the number of doses administered, except one study. Reproducible results were noted like an increase in plasma gelsolin and improved KOOS, WOMAC, and VAS scores.

Conclusion

GOLDIC has the potential to be a significant Orthobiologic modality considering its standardized preparation techniques, method of administration, and uniformly reproducible outcome measures. However, further high-quality evidence is needed to analyze the clinical efficiency and safety profile of GOLDIC.

Systematic review registration

INPLASY202350027 [https://doi.org/10.37766/inplasy2023.5.0027].

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Data availability

All data is contained within the manuscript.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu, India

    Madhan Jeyaraman & Naveen Jeyaraman

  2. Virginia Tech India, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu, India

    Madhan Jeyaraman

  3. Orthopaedic Research Group, Coimbatore, Tamil Nadu, India

    Madhan Jeyaraman & Girinivasan Chellamuthu

  4. Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India

    Madhan Jeyaraman, RP Packkyarathinam, Naveen Jeyaraman, Girinivasan Chellamuthu & Manish Khanna

  5. Department of Orthopaedics, Government Medical College, Omandurar Government Estate, Chennai, Tamil Nadu, India

    RP Packkyarathinam

  6. Department of Anaesthesiology and Pain Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

    Thamizhmathi Thangaraju

  7. Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore, India

    Girinivasan Chellamuthu

  8. Department of Orthopaedics, Dr KNS Mayo Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

    Manish Khanna

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  1. Madhan Jeyaraman
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Correspondence to Thamizhmathi Thangaraju.

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Jeyaraman, M., Packkyarathinam, R., Thangaraju, T. et al. GOLDIC Therapy Holds Promise as an Orthobiologic Agent: A Systematic Review of the Literature. JOIO 58, 858–865 (2024). https://doi.org/10.1007/s43465-024-01167-7

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  • DOI: https://doi.org/10.1007/s43465-024-01167-7

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