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The Most Common Type of HPV and Colposcopic Findings in Women with Ascus

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Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Introduction

The presence of atypical squamous cells of undetermined significance (ASCUS) from pap smear result should be followed by cytology follow-up, HPV DNA testing, or colposcopy, as there is a possibility of progress to cervical cancer. This study aims to evaluate the frequency of distinct HPV genotypes and colposcopy findings among women with ASCUS cytology results.

Methods

A descriptive study in 846 women was conducted in Dr. Cipto Mangunkusumo General Hospital using retrospective data between 2016 and 2018. Of 124 patients with ASCUS cytology results, all had HPV DNA examinations, but only 63 had colposcopy examinations. Participants who were married, sexually active, and willing to participate were included. Patients with incomplete data were excluded. The data were processed using Statistical Product and Service Solutions (SPSS) version 25.0.

Results

The incidence of ASCUS in the population was 14.7%. Among 124 subjects with ASCUS, 47 (37.9%) had a high-risk HPV infection. From 63 ASCUS women who underwent colposcopy, 27 subjects (42.8%) were normal. Type 52 of HPV showed the most frequent genotype appearing, especially within 30–50 years of age.

Conclusion

42.8% of the colposcopy findings for women with ASCUS were normal, and 37.9% of ASCUS women had a high-risk HPV infection. Type 52 was found to be the most frequent genotype that appears in ASCUS patients in Indonesia.

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Acknowledgements

The authors thank the medical records unit of Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jalan Salemba Raya No. 6, Jakarta, 10430, Indonesia

    Junita Indarti, Leonita Triwachyuni A. Sutrisna, Rabbania Hiksas & Kristian Alda

  2. Department of Pathologic Anatomy, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia

    Lisnawati Rachmadi

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  1. Junita Indarti
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  2. Lisnawati Rachmadi
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  3. Leonita Triwachyuni A. Sutrisna
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  4. Rabbania Hiksas
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  5. Kristian Alda
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Contributions

JI and LR took part in concept and design of study. LTAS, RH and KA performed the analysis, interpretation of data and wrote the manuscript. JI revised the paper and had primary responsibility for the final content. All authors agreed to the published version of the manuscript.

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Correspondence to Junita Indarti.

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Authors declare no conflict of interest in this study.

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Informed consent was not sought for the present study as this was a retrospective study. Only clinically relevant information was extracted, and patients’ privacy was protected.

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Indarti, J., Rachmadi, L., Sutrisna, L.T.A. et al. The Most Common Type of HPV and Colposcopic Findings in Women with Ascus. Indian J Gynecol Oncolog 20, 42 (2022). https://doi.org/10.1007/s40944-022-00641-0

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  • DOI: https://doi.org/10.1007/s40944-022-00641-0

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