Für die Behandlung der unkomplizierten, arzneimittelsensitiven Lungentuberkulose ist das seit 30 Jahren übliche sechsmonatige Standardschema nach wie vor aktuell. Mit Bedaquilin und Delamanid sind nun allerdings zwei neue Mittel zur Behandlung der Tuberkulose verfügbar. Im Nebenwirkungsprofil beider Medikamente ist das Potenzial für eine QT-Verlängerung zu beachten.
Literaturverzeichnis
Kalsdorf B, Olaru ID, Lange C, Heyckendorf J: Tuberkulose. Dtsch Med Wochenschr 2015; 140: 1508–12
Warner DF, Mizrahi V: Shortening treatment for tuberculosis — back to basics. N Engl J Med 2014 Oct 23; 371(17): 1642–3
Lode HM, Stahlmann R: Aktuelle Therapie der Tuberkulose. Arzneimitteltherapie 2015; 33(3): 47–53
Gillespie SH, Crook AM, McHugh TD, Mendel CM, Meredith SK, Murray SR, Pappas F, Phillips PP, Nunn AJ; REMoxTB Consortium: Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis. N Engl J Med 2014 Oct 23; 371(17): 1577–87
**dani A, Harrison TS, Nunn AJ, Phillips PP, Churchyard GJ, Charalambous S, Hatherill M, Geldenhuys H, McIlleron HM, Zvada SP, Mungofa S, Shah NA, Zizhou S, Magweta L, Shepherd J, Nyirenda S, van Dijk JH, Clouting HE, Coleman D, Bateson AL, McHugh TD, Butcher PD, Mitchison DA; RIFAQUIN Trial Team: High-dose rifapentine with moxifloxacin for pulmonary tuberculosis. N Engl J Med 2014 Oct 23; 371(17): 1599–608
Merle CS, Fielding K, Sow OB, Gninafon M, Lo MB, Mthiyane T, Odhiambo J, Amukoye E, Bah B, Kassa F, N'Diaye A, Rustomjee R, de Jong BC, Horton J, Perronne C, Sismanidis C, Lapujade O, Olliaro PL, Lienhardt C; OFLOTUB/Gatifloxacin for Tuberculosis Project: A four-month gatifloxacin-containing regimen for treating tuberculosis. N Engl J Med 2014 Oct 23; 371(17): 1588–98. Erratum: N Engl J Med 2015 Apr 23; 372(17): 1677
Schaberg T, Otto-Knapp R, Bauer T: Kurze Übersicht über neue Medikamente zur Therapie der multiresistenten Tuberkulose. Pneumologie 2015; 69(5): 282–6
Millard J, Ugarte-Gil C, Moore DA: Multidrug resistant tuberculosis. BMJ 2015 Feb 26; 350: h882.
Brändli O: Tuberkulose aktuell. Schweiz Med Forum 2013; 13(25): 493–8
Donnerer J: Wechselwirkungen der hormonellen Kontrazeptiva. Gynäkologe 2011; 44: 31–36
Schmiedel Y, Zimmerli S: Tuberkulose: Prävention, Latenz und Multiresistenz. Schweiz Med Forum 2015; 15(41): 918–24
Guglielmetti L, Le Dû D, Jachym M, Henry B, Martin D, Caumes E, Veziris N, M ä tivier N, Robert J; MDR-TB Management Group of the French National Reference Center for Mycobacteria and the Physicians of the French MDR-TB Cohort: Compassionate use of bedaquiline for the treatment of multidrug-resistant and extensively drug-resistant tuberculosis: interim analysis of a French cohort. Clin Infect Dis 2015 Jan 15; 60(2): 188–94
Diacon AH, Pym A, Grobusch MP, de los Rios JM, Gotuzzo E, Vasilyeva I, Leimane V, Andries K, Bakare N, {pDe} Marez T, Haxaire-Theeuwes M, Lounis N, Meyvisch P, De Paepe E, van Heeswijk RP, Dannemann B; TMC207-C208 Study Group: Multidrug-resistant tuberculosis and culture conversion with bedaquiline. N Engl J Med 2014 Aug 21; 371(8): 723–32
Dawson R, Diacon AH, Everitt D, van Niekerk C, Donald PR, Burger DA, Schall R, Spigelman M, Conradie A, Eisenach K, Venter A, Ive P, Page-Shipp L, Variava E, Reither K, Ntinginya NE, Pym A, von Groote-Bidlingmaier F, Mendel CM: Efficiency and safety of the combination of moxi-floxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. Lancet 2015 May 2; 385(9979): 1738–47
Gler MT, Skripconoka V, Sanchez-Garavito E, **ao H, Cabrera-Rivero JL, Vargas-Vasquez DE, Gao M, Awad M, Park SK, Shim TS, Suh GY, Danilovits M, Ogata H, Kurve A, Chang J, Suzuki K, Tupasi T, Koh WJ, Seaworth B, Geiter LJ, Wells CD: Delamanid for multidrug-resistant pulmonary tuberculosis. N Engl J Med 2012 Jun 7; 366 (23): 2151–60
Gupta R, Geiter LJ, Wells CD, Gao M, Cirule A, **ao H: Delamanid for extensively drug-resistant tuberculosis. N Engl J Med 2015 Jul 16; 373(3): 291–2
Olaru ID, von Groote-Bidlingmaier F, Heyckendorf J, Yew WW, Lange C, Chang KC: Novel drugs against tuberculosis: a clinician's perspective. Eur Respir J 2015 Apr; 45(4): 1119–31
Zumla A, Chakaya J, Centis R, D'Ambrosio L, Mwaba P, Bates M, Kapata N, Nyirenda T, Chanda D, Mfinanga S, Hoelscher M, Maeurer M, Migliori GB: Tuberculosis treatment and manage-ment — an update on treatment regimens, trials, new drugs, and adjunct therapies. Lancet Respir Med 2015 Mar; 3(3): 220–34
Dheda K, Barry CE 3rd, Maartens G: Tuberculosis. Lancet 2015 Sep 11. pii: S0140-6736(15)00151-8 [Epub ahead of print]
Zumla AI, Gillespie SH, Hoelscher M, Philips PP, Cole ST, Abubakar I, McHugh TD, Schito M, Maeurer M, Nunn AJ: New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects. Lancet Infect Dis 2014; 14(4): 327–40
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mörike, K. Herausforderungen der Tuberkulosetherapie. Pneumo News 7, 45–49 (2015). https://doi.org/10.1007/s15033-015-0277-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s15033-015-0277-6