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Früherkennung und Prävention von Typ-1-Diabetes

Das "window of opportunity" in den ersten 1.000 Tagen nutzen

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© Prof. Dr. Anette-Gabriele Ziegler

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Literatur

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  2. Ziegler AG et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA. 2013;309(23):2473-9

  3. Bonifacio E et al. Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA(1c). Diabetologia. 2008;51(7):1245-52

  4. Ziegler AG et al. Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia. 2012;55(7):1937-43

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  6. Warncke K et al. Elevations in blood glucose before and after the appearance of islet autoantibodies in children. J Clin Invest. 2022;132(20):e162123

  7. Insel RA et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care. 2015;38(10):1964-74

  8. Beyerlein A et al. Infections in early life and development of type 1 diabetes. JAMA. 2016;315(317):1899-901

  9. Vehik K et al. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019;25(12):1865-72

  10. Weiss A et al. Type 1 diabetes incidence and risk in children with a diagnosis of COVID-19. JAMA. 2023;329(23):2089-91

  11. Beyerlein A et al. Early infant growth is associated with the risk of islet autoimmunity in genetically susceptible children. Pediatr Diabetes. 2014;15(7):534-42

  12. Nucci AM et al. Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk. Diabetologia. 2021;64(4):826-35

  13. Ziegler AG et al. Yield of a public health screening of children for islet autoantibodies in Bavaria, Germany. JAMA. 2020;323(4):339-51

  14. Richardson TG et al. Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach. Nat Commun. 2022;13(1):2337

  15. Endesfelder D et al. Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production. Microbiome. 2016;4:17

  16. Vatanen T et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature. 2018;562(7728):589-94

  17. Uusitalo U et al. Association of early exposure of probiotics and islet autoimmunity in the teddy study. JAMA Pediatr. 2016;170(1):20-8

  18. Herold KC et al. An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes. N Engl J Med. 2019;381(7):603-13

  19. Forlenza GP et al. Effect of verapamil on pancreatic beta cell function in newly diagnosed pediatric type 1 diabetes: a randomized clinical trial. JAMA. 2023;329(12):990-9

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Authors and Affiliations

  1. Institut für Diabetes­forschung, Helmholtz Zentrum ­München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany

    Anette-Gabriele Ziegler

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  1. Anette-Gabriele Ziegler
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  2. Sandra Hummel
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Ziegler, AG., Hummel, S. Früherkennung und Prävention von Typ-1-Diabetes. Pädiatrie 35 (Suppl 1), 34–39 (2023). https://doi.org/10.1007/s15014-023-4923-x

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