Abstract
Introduction
para-Aminosalicylic acid (PAS) is commonly used in the treatment of drug-resistant tuberculosis, including multidrug-resistant tuberculosis. Since its first use in the 1940s, hypersensitivity reactions frequently limit its use in clinical practice. Cases of successful desensitization against PAS using orally administered ascending doses are described in the literature.
Case report
A 25-year-old patient with severe pulmonary multidrug-resistant tuberculosis developed drug fever with rash, acral cyanosis, and shivering immediately after the intravenous application of PAS. Hard gelatine capsules containing PAS dry substance were prepared in order to desensitize this patient. Encapsulated PAS was applied orally in rising doses starting with 10 mg/day and doubling the dose every 2 days until the half-maximal dose of 5,120 mg was reached. Desensitization covers a period of 21 days. Subsequent intravenous application of PAS at the full dose was well tolerated. In a 12-month follow-up period, no more allergic reactions appeared.
Conclusions
PAS dry substance encapsulated in hard gelatine capsules and administered orally in rising concentrations may be useful to archive a successful desensitization for subsequent intravenous applications.
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References
World Health Organization (WHO). The Global MDR-TB & XDR-TB Response Plan 2007–2008. 2007.
World Health Organization (WHO). Country profiles on tuberculosis. Global TB database.
Iseman MD. Tuberculosis down through the centuries. In: Pine Jr JW, Millet KC, Cook RE, editors. A clinician’s guide to tuberculosis. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 1–19.
Mandell GL, Petri WA Jr. Antimicrobial agents: drugs used in the chemotherapy of tuberculosis, Mycobacterium avium complex disease, and leprosy. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman & Gilman’s the pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill; 2001. p. 1281–1283.
Berté SJ, Dewlett HJ. Isoniazid and para-aminosalicylic acid toxicity in 513 cases: a study including high doses of INH and gastrointestinal intolerance to PAS. Dis Chest. 1959;36:146–51.
Berté SJ, Dimase JD, Christianson CS. Isoniazid, para-aminosalicylic acid, and streptomycin intolerance in 1,744 patients. An analysis of reactions to single drugs and drug groups plus data on multiple reactions, type and time of reactions, and desensitization. Am Rev Respir Dis. 1964;90:598–606.
Wilson JW, Kelkar P, Frigas E. para-Aminosalicylic acid (PAS) desensitization review in a case of multidrug-resistant pulmonary tuberculosis. Int J Tuberc Lung Dis. 2003;7:493–7.
Schaberg T, Forßbohm M, Hauer B, Kirsten D, Kropp R, Loddenkemper R, Magdorf K, Rieder H, Sagebiell D, Urbanczik R. Guidelines for the medicamentous treatment of tuberculosis in adults and children. Pneumologie. 2001;55:494–511.
Otten H, Plempel M, Siegenthaler W. Bible of antibiotics. 4th ed. Stuttgart: Georg Thieme Verlag; 1975. p. 620–8.
Berning SE, Peloquin CA. Antimycobacterial agents: p-aminosalicylic acid. Antimicrobial chemotherapy. Baltimore: Williams and Wilkins; 1998. p. 663–8.
Crofton J. Desensitization to streptomycin and PAS. Br Med J. 1953;2:1014–7.
Simpson DG, Walker JH. Hypersensitivity to para-aminosalicylic acid. Am J Med. 1960;29:297–306.
Gupta SK, Palmer HD. Short-term ACTH therapy for desensitisation against anti-tuberculosis drugs. Br J Dis Chest. 1959;53:197–201.
Houghton LE. Combined corticotrophin therapy and chemotherapy in pulmonary tuberculosis, with special reference to hypersensitive reactions. Lancet. 1954;266:595–8.
Francis RS, Gupta SK. The use of corticotrophin in rapid desensitization to PAS. Tubercle. 1958;39:236–9.
Lipsky BA, Hirschmann JV. Drug fever. JAMA. 1981;245:851–4.
Acknowledgments
We thank Ines Wilms for the technical support and photo documentation.
Conflict of interest
J. Becker is a Medical Scientific Research employee of RIEMSER Arzneimittel AG. Recommendations or any other kind of statements supporting or hindering the use of the product of his company are not implemented in the publication. Therefore, no conflict of interest exists.
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Vesenbeckh, S.M., Becker, J., Huhnt, C. et al. Successful oral desensitization to i.v. para-aminosalicylic acid (PAS) using encapsulated PAS dry substance. Infection 40, 199–202 (2012). https://doi.org/10.1007/s15010-011-0172-y
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DOI: https://doi.org/10.1007/s15010-011-0172-y