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Leitlinie zum Management IgE-vermittelter Nahrungsmittelallergien

S2k-Leitlinie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI) in Zusammenarbeit mit dem Ärzteverband Deutscher Allergologen (AeDA), dem Berufsverband der Kinder- und Jugendärzte (BVKJ), dem Deutschen Allergie- und Asthmabund (DAAB), der Deutschen Dermatologischen Gesellschaft (DDG), der Deutschen Gesellschaft für Ernährung (DGE), der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, der Deutschen Gesellschaft für Kinder- und Jugendmedizin (DGKJ), der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA), der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP), der Deutschen Gesellschaft für Gastroenterologie und Ernährung (GPGE), der Deutschen Kontaktallergie-Gruppe (DKG), der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI), dem BerufsVerband Oecotrophologie e.V. (VDOE) und der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF)

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An Erratum to this article was published on 21 December 2015

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Abbreviations

AAAAI:

American Academy of Allergy, Asthma & Immunology

AGATE:

Arbeitsgemeinschaft Anaphylaxie — Training und Edukation

ASS:

Acetylsalicylsäure

BAT:

Basophilenaktivierungstest

BK:

Berufskrankheit

CCD:

Cross-reactive carbohydrate determinants

CSACI:

Canadian Society of Allergy and Clinical Immunology

DBPCFC:

Double-blind placebo-controlled food challenge

DGES:

Studie zur Gesundheit Erwachsener in Deutschland

EAACI:

European Academy of Allergy and Clinical Immunology

EGID:

Eosinophilic gastrointestinal disorders

FPIES:

Food protein-induced enterocolitis syndrom

HMW:

High molecular weight

IgE:

Immunglobulin E

IgG:

Immunglobulin G

GÖR:

Gastroösophagealer Reflux

KI:

Konfidenzinterval

KU:

Kontakturtikaria

LJ:

Lebensjahr

LMIV:

Lebensmittelinformationsverordnung

LoQ:

Limit of quantation

LTP:

Lipidtransferprotein

MdE:

Minderung der Erwerbsfähigkeit

NPV:

Negative predictive value

NSAID:

Nichtsteroidale Entzündungshemmer

nsLTP:

Non-specific lipid transfer protein

OAS:

Orales Allergiesyndrom

OIT:

Orale Immuntherapie

PKD:

Proteinkontaktdermatitis

PPI:

Protonenpumpeninhibitor

PPV:

Positive predictive value

PR-10:

Pathogenesis-related protein family 10

SCIT:

Subkutane Immuntherapie

SIT:

Spezifische Immuntherapie

SLIT:

Sublinguale Immuntherapie

WDEIA:

Wheat-dependent, exercise-induced anaphylaxis

Literatur

  1. Niggemann B, Beyer K, Erdmann S, Fuchs T, Kleine-Tebbe J, Lepp U et al. Standardisierung von oralen Provokationstests bei Verdacht auf Nahrungsmittelallergie. Allergo J 2011;20:149–60

    Google Scholar 

  2. Ruëff F, Bergmann KC, Brockow K, Fuchs T, Grübl A, Jung K et al. Hauttests zur Diagnostik von allergischen Soforttypreaktionen. Allergo J 2010;19:402–15

    Google Scholar 

  3. Worm M, Jappe U, Kleine-Tebbe J, Schäfer C, Reese I, Saloga J et al. Nahrungsmittelallergie infolge immunologischer Kreuzreaktivitäten mit Inhalationsallergenen. Allergo J Int 2014;23:16–31

    Article  Google Scholar 

  4. Lepp U, Ballmer-Weber B, Beyer K, Erdmann S, Fuchs T, Henzgen M et al. Therapiemöglichkeiten bei der IgE-vermittelten Nahrungsmittelallergie. Allergo J 2010;19:187–95

    Google Scholar 

  5. Werfel T, Fuchs T, Reese I, Erdmann S, Henzgen M, Kleine-Tebbe J et al. Vorgehen bei vermuteter Nahrungsmittelallergie bei atopischer Dermatitis. Positionspapier der Arbeitsgruppe Nahrungsmittelallergie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAI). Allergologie 2003;26:33–41

    Article  Google Scholar 

  6. Reese I, Zuberbier T, Bunselmeyer B, Erdmann S, Henzgen M, Fuchs T et al. Diagnostisches Vorgehen bei Verdacht auf eine pseudoallergische Reaktion durch Nahrungsmittelinhaltsstoffe. Allergo J 2008;17: 540–9

    Google Scholar 

  7. Kleine-Tebbe J, Ballmer-Weber B, Beyer K, Erdmann S, Fuchs T, Henzgen M et al. [In vitro diagnostics and molecular basis of IgE-mediated food allergies]. Allergologie 2009;32:177–94

    Article  Google Scholar 

  8. Muche-Borowski C, Selbmann HK, Nothacker M, Müller W, Kopp I; Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften — Ständige Kommission Leitlinien, eds. AWMF-Regelwerk Leitlinien. 1st ed. 2012. http://www.awmf.org/fileadmin/user_upload/Leitlinien/AWMF-Regelwerk/AWMF-Regelwerk-Weblinks.pdf. Zugegriffen: 31.07.2014

  9. Beyer M, Geraedts M, Gerlach FM, Gülich M, Kopp I, Lelgemann M et al; Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Ärztliches Zentrum für Qualität in der Medizin, eds. Deutsches Instrument zur methodischen Leitlinien-Bewertung (DELBI): Fassung 2005/2006 + Domäne 8 (2008). 2008. http://www.aezq.de/mdb/edocs/pdf/literatur/delbi-fassung-2005-2006-domaene-8-2008.pdf. Zugegriffen: 31.07.2014

  10. Nast A, Sporbeck B, Jacobs A, Erdmann R, Roll S, Sauerland U et al. Study of perceptions of the extent to which guideline recommendations are binding: a survey of commonly used terminology. Dtsch Arztebl Int 2013;110:663–8

    PubMed Central  PubMed  Google Scholar 

  11. Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C et al. EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy. Allergy 2014;69:1008–25

    Article  CAS  PubMed  Google Scholar 

  12. Silva D de, Panesar SS, Thusu S, Rader T, Werfel T, Muraro A et al. The acute and long-term management of food allergy: protocol for a rapid systematic review. Clin Transl Allergy 2013;3:12

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K et al. The diagnosis of food allergy: a systematic review and meta-analysis. Allergy 2014;69:76–86

    Article  CAS  PubMed  Google Scholar 

  14. Sicherer SH, Sampson HA. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol 2007;120:491–503; quiz 4-5

    Article  PubMed  Google Scholar 

  15. Flokstra-de Blok BM, Dubois AE. Quality of life measures for food allergy. Clin Exp Allergy 2012;42:1014–20

    Article  CAS  PubMed  Google Scholar 

  16. Nwaru BI, Hickstein L, Panesar SS, Muraro A, Werfel T, Cardona V et al. The epidemiology of food allergy in Europe: a systematic review and meta-analysis. Allergy 2014;69:62–75

    Article  CAS  PubMed  Google Scholar 

  17. Zuberbier T, Edenharter G, Worm M, Ehlers I, Reimann S, Hantke T et al. Prevalence of adverse reactions to food in Germany — a population study. Allergy 2004;59:338–45

    Article  CAS  PubMed  Google Scholar 

  18. Roehr CC, Edenharter G, Reimann S, Ehlers I, Worm M, Zuberbier T et al. Food allergy and non-allergic food hypersensitivity in children and adolescents. Clin Exp Allergy 2004;34:1534–41

    Article  CAS  PubMed  Google Scholar 

  19. Langen U, Schmitz R, Steppuhn H. Häufigkeit allergischer Erkrankungen in Deutschland. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 2013;56:698–706

    Article  CAS  Google Scholar 

  20. Worm M, Eckermann O, Dolle S, Aberer W, Beyer K, Hawranek T et al. Triggers and treatment of anaphylaxis: an analysis of 4000 cases from Germany, Austria and Switzerland. Dtsch Arztebl Int 2014;111:367–75

    PubMed Central  PubMed  Google Scholar 

  21. Muche-Borowski C, Kopp M, Reese I, Sitter H, Werfel T, Schafer T. Allergy prevention. Dtsch Arztebl Int 2009;106:625–31

    PubMed Central  PubMed  Google Scholar 

  22. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. (AWMF), eds. Leitlinien-Detailansicht: Allergieprävention. Registernummer 061 - 016. 2014. http://www.awmf.org/leitlinien/detail/ll/061-016.html. Zugegriffen: 01.09.2014

  23. Pali-Scholl I, Herzog R, Wallmann J, Szalai K, Brunner R, Lukschal A et al. Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization. Clin Exp Allergy 2010;40:1091–8

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M et al. ICON: food allergy. J Allergy Clin Immunol 2012;129:906–20

    Article  PubMed  Google Scholar 

  25. Sicherer SH, Sampson HA. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 2014;133:291–307; quiz 8

    Article  CAS  PubMed  Google Scholar 

  26. Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 2010;126(6 Suppl):S1–58

    PubMed Central  PubMed  Google Scholar 

  27. Commins SP, Platts-Mills TA. Tick bites and red meat allergy. Curr Opin Allgery Clin Immunol 2013;13:354–9

    Article  CAS  Google Scholar 

  28. Wood A, Baxter G, Thies F, Kyle J, Duthie G. A systematic review of salicylates in foods: estimated daily intake of a Scottish population. Mol Nutr Food Res 2011;55 Suppl 1:S7–S14

    Article  CAS  PubMed  Google Scholar 

  29. Diesner SC, Pali-Scholl I, Jensen-Jarolim E, Untersmayr E. Mechanismen und Risikofaktoren für Typ 1 Nahrungsmittelallergien: Die Rolle der gastrischen Verdauung. Wien Med Wochenschr 2012;162:513–8

    Article  PubMed  Google Scholar 

  30. Worm M, Babina M, Hompes S. Causes and risk factors for anaphylaxis. J Dtsch Dermatol Ges 2013;11:44–50

    PubMed  Google Scholar 

  31. Renz H, Biedermann T, Bufe A, Eberlein B, Jappe U, Ollert M et al. In-vitro-Allergiediagnostik. Allergo J 2010;19: 110–28

    Google Scholar 

  32. Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, Hage M van, Baena-Cagnani CE et al. A WAO - ARIA - GA(2)LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J 2013;6:17

    Article  PubMed Central  PubMed  Google Scholar 

  33. Kleine-Tebbe J, Ballmer-Weber B, Beyer K, Erdmann S, Fuchs T, Henzgen M et al. In-vitro-Diagnostik und molekulare Grundlagen von IgE-vermittelten Nahrungsmittelallergien. Allergo J 2009;18:132–46

    Google Scholar 

  34. Kleine-Tebbe J. Molekulare Allergiediagnostik: Entwicklung und Bedeutung für die klinische Praxis. Allergologie 2013;36:327

    Article  Google Scholar 

  35. Steckelbroeck S, Ballmer-Weber BK, Vieths S. Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes. J Allergy Clin Immunol 2008;121:1323–30

    Article  CAS  PubMed  Google Scholar 

  36. Armbruster DA, Pry T. Limit of blank, limit of detection and limit of quantitation. Clin Biochem Rev 2008;29 Suppl 1:S49–52

    PubMed Central  PubMed  Google Scholar 

  37. Ballmer-Weber BK, Vieths S. Soy allergy in perspective. Curr Opin Allergy Clinical Immunol 2008;8:270–5

    Article  CAS  Google Scholar 

  38. Hamilton R, Matsson P, Chan S, Cleve M van, Hovanec-Burns D, Magnusson C et al. Analytical performance characteristics. Quality assurance and clinical utility of immunological assays for human immunglobuline E (IgE) antibodies of defined allergen specificities; 3rd ed, I/LA20-A3, International CLSI-Guideline 2015; in preparation

  39. Ballmer-Weber BK, Hoffmann-Sommergruber K. Molecular diagnosis of fruit and vegetable allergy. Curr Opin Allgery Clin Immunol 2011;11:229–35

    Article  CAS  Google Scholar 

  40. Breiteneder H, Ebner C. Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 2000;106:27–36

    Article  CAS  PubMed  Google Scholar 

  41. Jappe U, Petersen A, Raulf-Heimsoth M. Allergische Soforttypreaktionen und kreuzreaktive Kohlenhydratepitope (CCD). Allergo J 2013;22:25–32

    Article  Google Scholar 

  42. Jappe U. Allergie auf Säugetierfleisch. Hautarzt 2012;63:299–306

    Article  CAS  PubMed  Google Scholar 

  43. Henzgen M, Ballmer-Weber B, Erdmann S, Fuchs T, Kleine-Tebbe J, Lepp U et al. Hauttestungen mit Nahrungsmittelallergenen. Allergo J 2008;17:401–6

    Google Scholar 

  44. Du Toit G, Santos A, Roberts G, Fox AT, Smith P, Lack G. The diagnosis of IgE-mediated food allergy in childhood. Pediatr Allergy Immunol 2009;20:309–19

    Article  CAS  PubMed  Google Scholar 

  45. Zeng Q, Dong SY, Wu LX, Li H, Sun ZJ, Li JB et al. Variable food-specific IgG antibody levels in healthy and symptomatic Chinese adults. PloS one 2013;8:e53612

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  46. Benson TE, Arkins JA. Cytotoxic testing for food allergy: evaluation of reproducibility and correlation. J Allergy Clin Immunol 1976;58:471–6

    Article  CAS  PubMed  Google Scholar 

  47. Committee of Public Health. Statement on cytotoxic testing for food allergy (Bryan’s test). Bull N Y Acad Med 1988;64:117–9

    Google Scholar 

  48. Ernst E. Iridology: a systematic review. Forsch Komplementarmed 1999;6:7–9

    Article  CAS  PubMed  Google Scholar 

  49. Garrow JS. Kinesiology and food allergy. Br Med J (Clin Res Ed) 1988;296(6636):1573–4

    Article  CAS  Google Scholar 

  50. Niggemann B, Gruber C. Unproven diagnostic procedures in IgE-mediated allergic diseases. Allergy 2004;59:806–8

    Article  CAS  PubMed  Google Scholar 

  51. Sethi TJ, Lessof MH, Kemeny DM, Lambourn E, Tobin S, Bradley A. How reliable are commercial allergy tests? Lancet 1987;1:92–4

    Article  CAS  PubMed  Google Scholar 

  52. Stapel SO, Asero R, Ballmer-Weber BK, Knol EF, Strobel S, Vieths S et al. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy 2008;63:793–6

    Article  CAS  PubMed  Google Scholar 

  53. Wüthrich B. Unproven techniques in allergy diagnosis. J Investig Allergol Clin Immunol 2005;15:86–90

    PubMed  Google Scholar 

  54. Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol 2013;131:805–12

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  55. Sampson HA. Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol 1999;103:717–28

    Article  CAS  PubMed  Google Scholar 

  56. Hattevig G, Kjellman B, Bjorksten B. Clinical symptoms and IgE responses to common food proteins and inhalants in the first 7 years of life. Clin Allergy 1987;17:571–8

    Article  CAS  PubMed  Google Scholar 

  57. Boyano-Martinez T, Garcia-Ara C, Diaz-Pena JM, Martin-Esteban M. Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. J Allergy Clin Immunol 2002;110:304–9

    Article  CAS  PubMed  Google Scholar 

  58. Keet CA, Matsui EC, Dhillon G, Lenehan P, Paterakis M, Wood RA. The natural history of wheat allergy. Ann Allergy Asthma Immunol 2009;102:410–5

    Article  CAS  PubMed  Google Scholar 

  59. Webb LM, Lieberman P. Anaphylaxis: a review of 601 cases. Ann Allergy Asthma Immunol 2006;97:39–43

    Article  PubMed  Google Scholar 

  60. Green TD, LaBelle VS, Steele PH, Kim EH, Lee LA, Mankad VS et al. Clinical characteristics of peanut-allergic children: recent changes. Pediatrics 2007;120:1304–10

    Article  PubMed  Google Scholar 

  61. Savage JH, Limb SL, Brereton NH, Wood RA. The natural history of peanut allergy: extending our knowledge beyond childhood. J Allergy Clin Immunol 2007;120: 717–9

    Article  PubMed  Google Scholar 

  62. Neuman-Sunshine DL, Eckman JA, Keet CA, Matsui EC, Peng RD, Lenehan PJ et al. The natural history of persistent peanut allergy. Ann Allergy Asthma Immunol 2012;108:326–31 e3

    Article  PubMed  Google Scholar 

  63. Spergel JM, Beausoleil JL, Pawlowski NA. Resolution of childhood peanut allergy. Ann Allergy Asthma Immunol 2000;85:473–6

    Article  CAS  PubMed  Google Scholar 

  64. Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol 2001;107:367–74

    Article  CAS  PubMed  Google Scholar 

  65. Fleischer DM, Conover-Walker MK, Matsui EC, Wood RA. The natural history of tree nut allergy. J Allergy Clin Immunol 2005;116:1087–93

    Article  CAS  PubMed  Google Scholar 

  66. Lopata AL, Lehrer SB. New insights into seafood allergy. Curr Opin Allergy Clin Immunol 2009;9:270–7

    Article  CAS  PubMed  Google Scholar 

  67. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow’s milk allergy. J Allergy Clin Immunol 2007;120:1172–7

    Article  CAS  PubMed  Google Scholar 

  68. Rockmann H, Geel MJ van, Knulst AC, Huiskes J, Bruijnzeel-Koomen CA, Bruin-Weller MS de. Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis. Clin Transl Allergy 2014;4:9

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  69. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 2007;120:638–46

    Article  PubMed  Google Scholar 

  70. Ring J, Beyer K, Biedermann T, Bircher A, Duda D, Fischer J et al. Akuttherapie und Management der Anaphylaxie. Allergo J 2014;23:96–112

    Article  Google Scholar 

  71. Silva D de, Geromi M, Halken S, Host A, Panesar SS, Muraro A et al. Primary prevention of food allergy in children and adults: systematic review. Allergy 2014;69(5):581–9

    Article  PubMed  Google Scholar 

  72. Ellis AK, Day JH. Diagnosis and management of anaphylaxis. CMAJ 2003;169:307–11

    PubMed Central  PubMed  Google Scholar 

  73. Greenberger PA, Patterson R. The prevention of immediate generalized reactions to radiocontrast media in high-risk patients. J Allergy Clin Immunol 1991;87:867–72

    Article  CAS  PubMed  Google Scholar 

  74. Reimers AM, Müller UM. Behandlung des anaphylaktischen Schocks. Therapeutische Umschau 2001;58:325–8

    Article  CAS  PubMed  Google Scholar 

  75. Kaiser H, Kley H-K. Cortisontherapie: Corticoide in Klinik und Praxis. 11. neubearb. Aufl. Stuttgart — New York: Thieme; 2002

    Google Scholar 

  76. Stark BJ, Sullivan TJ. Biphasic and protracted anaphylaxis. J Allergy Clin Immunol 1986;78:76–83

    Article  CAS  PubMed  Google Scholar 

  77. Silva D de, Geromi M, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K et al. Acute and long-term management of food allergy: systematic review. Allergy 2014;69:159–67

    Article  PubMed  Google Scholar 

  78. Kocoshis S, Gryboski JD. Use of cromolyn in combined gastrointestinal allergy. JAMA 1979;242:1169–73

    Article  CAS  PubMed  Google Scholar 

  79. Ortolani C, Pastorello E, Zanussi C. Prophylaxis of adverse reactions to foods. A double-blind study of oral sodium cromoglycate for the prophylaxis of adverse reactions to foods and additives. Ann Allergy 1983;50:105–9

    CAS  PubMed  Google Scholar 

  80. Van Elburg RM, Heymans HS, De Monchy JG. Effect of disodiumcromoglycate on intestinal permeability changes and clinical response during cow’s milk challenge. Pediatr Allergy Immunol 1993;4:79–85

    Article  PubMed  Google Scholar 

  81. Lunardi C, Bambara LM, Biasi D, Cortina P, Peroli P, Nicolis F et al. Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance. Clin Exp Allergy 1991;21:569–72

    Article  CAS  PubMed  Google Scholar 

  82. Stefanini GF, Saggioro A, Alvisi V, Angelini G, Capurso L, di Lorenzo G et al. Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients. Scan J Gastroenterol 1995;30:535–41

    Article  CAS  Google Scholar 

  83. Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, Heide S van der et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 2010;59:1213–21

    Article  CAS  PubMed  Google Scholar 

  84. Burks AW, Sampson HA. Double-blind placebo-controlled trial of oral cromolyn in children with atopic dermatitis and documented food hypersensitivity. J Allergy Clin Immunol 1988;81:417–23

    Article  CAS  PubMed  Google Scholar 

  85. Raithel M, Weidenhiller M, Wilken V, Hochberger J, Muehldorfer S, Hahn E. Potential use of budesonide in food hypersensitivity. In: Dignass A, Gross V, Buhr HJ, James OFW, eds. Topical steroids in gastroenterology and hepatology. Dordrecht: Kluwer Academic Publisher BV; 2004. p. 63–70

    Google Scholar 

  86. Straumann A, Conus S, Degen L, Felder S, Kummer M, Engel H et al. Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 2010;139:1526–37, 37 e1

    Article  CAS  PubMed  Google Scholar 

  87. Tan AC, Kruimel JW, Naber TH. Eosinophilic gastroenteritis treated with non-enteric-coated budesonide tablets. Eur J Gastroenterol Hepatol 2001;13:425–7

    Article  CAS  PubMed  Google Scholar 

  88. Alonso A, Seoane MA, Iraneta SG, Scavini LM, Rodriguez SM. A citrus fruit-exclusion diet in sensitive patients and its influence on specific antibodies. J Investig Allergol Clin Immunol 1994;4:146–8

    CAS  PubMed  Google Scholar 

  89. Chen JL, Bahna SL. Spice allergy. Ann Allergy Asthma Immunol 2011;107:191–9; quiz 9, 265

    Article  CAS  PubMed  Google Scholar 

  90. Hill DJ, Murch SH, Rafferty K, Wallis P, Green CJ. The efficacy of amino acid-based formulas in relieving the symptoms of cow’s milk allergy: a systematic review. Clin Exp Allergy 2007;37:808–22

    Article  CAS  PubMed  Google Scholar 

  91. Lever R, MacDonald C, Waugh P, Aitchison T. Randomised controlled trial of advice on an egg exclusion diet in young children with atopic eczema and sensitivity to eggs. Pediatr Allergy Immunol 1998;9:13–9

    Article  CAS  PubMed  Google Scholar 

  92. Niggemann B, Berg A von, Bollrath C, Berdel D, Schauer U, Rieger C et al. Safety and efficacy of a new extensively hydrolyzed formula for infants with cow’s milk protein allergy. Pediatr Allergy Immunol 2008;19:348–54

    Article  CAS  PubMed  Google Scholar 

  93. Europäische Union, ed. Verordnung (EU) Nr. 1169/2011 des Europäischen Parlaments und des Rates vom 25. Oktober 2011 betreffend die Information der Verbraucher über Lebensmittel und zur Änderung der Verordnungen (EG) Nr. 1924/2006 und (EG) Nr. 1925/2006 des Europäischen Parlaments und des Rates und zur Aufhebung der Richtlinie 87/250/EWG der Kommission, der Richtlinie 90/496/EWG des Rates, der Richtlinie 1999/10/EG der Kommission, der Richtlinie 2000/13/EG des Europäischen Parlaments und des Rates, der Richtlinien 2002/67/EG und 2008/5/EG der Kommission und der Verordnung (EG) Nr. 608/2004 der Kommission. 2011; http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2011:304:0018:0063:de:PDF. Zugegriffen 23.07.2014

  94. Reese I, Schäfer C. Einsatz von therapeutischen Spezialnahrungen im Säuglingsalter — Bedarfsdeckung unter veränderten Voraussetzungen. Allergologie 2013;36:502–9

    Article  Google Scholar 

  95. Koletzko S, Niggemann B, Friedrichs F, Koletzko B. Vorgehen bei Säuglingen mit Verdacht auf Kuhmilchproteinallergie. Monatsschr Kinderheilkd 2009;157:687–91

    Article  Google Scholar 

  96. Ernährungskommission der Deutschen Gesellschaft für Kinder- und Jugendmedizin und Ernährungskommission der Schweizerischen Gesellschaft für Pädiatrie, eds. Stellungnahme zur Verwendung von Säuglingsnahrungen auf Sojaeiweißbasis. Monatsschr Kinderheilkd 2006;154:913–6

  97. Ellis MH, Short JA, Heiner DC. Anaphylaxis after ingestion of a recently introduced hydrolyzed whey protein formula. J Pediatr 1991;118:74–7

    Article  CAS  PubMed  Google Scholar 

  98. Host A, Halken S. Hypoallergenic formulas — when, to whom and how long: after more than 15 years we know the right indication! Allergy 2004;59 Suppl 78:45–52

    Article  PubMed  Google Scholar 

  99. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. (AWMF); Deutsche Gesellschaft für Osteologie e. V., eds. Prophylaxe, Diagnostik und Therapie der Osteoporose bei Erwachsenen. 2014; http://www.awmf.org/uploads/tx_szleitlinien/034-003l_S3_Prophylaxe_Diagnostik_Therapie_Osteoporose_Erwachsenen_2009-abgelaufen.pdf. Zugegriffen: 15.08.2014

  100. Miller JB. A double-blind study of food extract injection therapy: a preliminary report. Ann Allergy 1977;38:185–91.

    CAS  PubMed  Google Scholar 

  101. Oppenheimer JJ, Nelson HS, Bock SA, Christensen F, Leung DY. Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol 1992;90:256–62

    Article  CAS  PubMed  Google Scholar 

  102. Asero R. Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive

  103. Bolhaar STHP, Tiemessen MM, Zuidmeer L, Leeuwen A van, Hoffmann-Sommergruber K, Bruijnzeel-Koomen CAFM et al. Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges. Clin Exp Allergy 2004;34:761–9

    Article  CAS  PubMed  Google Scholar 

  104. Bucher X, Pichler WJ, Dahinden CA, Helbling A. Effect of tree pollen specific, subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut. Allergy 2004;59:1272–6

    Article  CAS  PubMed  Google Scholar 

  105. Mauro M, Russello M, Incorvaia C, Gazzola G, Frati F, Moingeon P et al. Birch-apple syndrome treated with birch pollen immunotherapy. Int Arch Allergy Immunol 2011;156:416–22

    Article  PubMed  Google Scholar 

  106. Hoffen E van, Peeters KA, Neerven RJ van, Tas CW van der, Zuidmeer L, van Ieperen-van Dijk AG et al. Effect of birch pollen-specific immunotherapy on birch pollen-related hazelnut allergy. J Allergy Clin Immunol 2011;127:100–1, 1 e1-3

    Article  PubMed  Google Scholar 

  107. Enriquez S, Pantoja-Reyes NI. Form-function analysis of the effect of canopy morphology on leaf self-shading in the seagrass Thalassia testudinum. Oecologia 2005;145:235–43

    Article  PubMed  Google Scholar 

  108. Fernandez-Rivas M, Garrido Fernandez S, Nadal JA, Diaz de Durana MD, Garcia BE, Gonzalez-Mancebo E et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy 2009 Jun;64:876–83

    Article  CAS  PubMed  Google Scholar 

  109. Fleischer DM, Burks AW, Vickery BP, Scurlock AM, Wood RA, Jones SM et al. Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial. J Allergy Clin Immunol 2013;131:119–27 e1-7

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  110. Kim EH, Bird JA, Kulis M, Laubach S, Pons L, Shreffler W et al. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. J Allergy Clin Immunol 2011;127:640–46

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  111. Hansen KS, Khinchi MS, Skov PS, Bindslev-Jensen C, Poulsen LK, Malling H-J. Food allergy to apple and specific immunotherapy with birch pollen. Mol Nutr Food Res 2004;48:441–8

    Article  CAS  PubMed  Google Scholar 

  112. Anagnostou K, Islam S, King Y, Foley L, Pasea L, Bond S et al. Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. Lancet 2014;383:1297–304

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  113. Burks AW, Jones SM, Wood RA, Fleischer DM, Sicherer SH, Lindblad RW et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 2012;367:233–43

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  114. Caminiti L, Passalacqua G, Barberi S, Vita D, Barberio G, De Luca R et al. A new protocol for specific oral tolerance induction in children with IgE-mediated cow’s milk allergy. Allergy Asthma Proc 2009;30:443–8

    Article  CAS  PubMed  Google Scholar 

  115. Dello Iacono I, Tripodi S, Calvani M, Panetta V, Verga MC, Miceli Sopo S. Specific oral tolerance induction with raw hen’s egg in children with very severe egg allergy: a randomized controlled trial. Pediatr Allergy Immunol 2013;24:66–74

    Article  PubMed  Google Scholar 

  116. Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, Schroeder JT, Hamilton RG, Boden S et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol 2012;129:448–55

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  117. Longo G, Barbi E, Berti I, Meneghetti R, Pittalis A, Ronfani L et al. Specific oral tolerance induction in children with very severe cow’s milk-induced reactions. J Allergy Clin Immunol 2008;121:343–7

    Article  CAS  PubMed  Google Scholar 

  118. Mansouri M, Movahhedi M, Pourpak Z, Akramian R, Shokohi Shormasti R, Mozaffari H et al. Oral desensitization in children with IgE-mediated cow’s milk allergy: a prospective clinical trial. Tehran Univ Med J 2007;65: 11–8

    Google Scholar 

  119. Martorell A, De la Hoz B, Ibanez MD, Bone J, Terrados MS, Michavila A et al. Oral desensitization as a useful treatment in 2-year-old children with cow’s milk allergy. Clin Exp Allergy 2011;41:1297–304

    Article  CAS  PubMed  Google Scholar 

  120. Meglio P, Giampietro PG, Carello R, Gabriele I, Avitabile S, Galli E. Oral food desensitization in children with IgE-mediated hen’s egg allergy: a new protocol with raw hen’s egg. Pediatr Allergy Immunol 2013;24:75–83

    Article  PubMed  Google Scholar 

  121. Morisset M, Moneret-Vautrin DA, Guenard L, Cuny JM, Frentz P, Hatahet R et al. Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow’s milk allergy and 90 children with egg allergy. Eur Ann Allergy Clin Immunol 2007;39:12–9

    CAS  PubMed  Google Scholar 

  122. Pajno GB, Caminiti L, Ruggeri P, De Luca R, Vita D, La Rosa M et al. Oral immunotherapy for cow’s milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study. Ann Allergy Asthma Immunol 2010;105:376–81

    Article  CAS  PubMed  Google Scholar 

  123. Patriarca G, Nucera E, Roncallo C, Pollastrini E, Bartolozzi F, De Pasquale T et al. Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther 2003;17:459–65

    Article  CAS  PubMed  Google Scholar 

  124. Patriarca G, Schiavino D, Nucera E, Schinco G, Milani A, Gasbarrini GB. Food allergy in children: results of a standardized protocol for oral desensitization. Hepatogastroenterology 1998;45:52–8

    CAS  PubMed  Google Scholar 

  125. Salmivesi S, Korppi M, Makela MJ, Paassilta M. Milk oral immunotherapy is effective in school-aged children. Acta Paediatr 2013;102:172–6

    Article  PubMed  Google Scholar 

  126. Skripak JM, Nash SD, Rowley H, Brereton NH, Oh S, Hamilton RG et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow’s milk allergy. J Allergy Clin Immunol 2008;122:1154–60

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  127. Varshney P, Jones SM, Scurlock AM, Perry TT, Kemper A, Steele P et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol 2011;127:654–60

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  128. Vazquez-Ortiz M, Alvaro M, Piquer M, Dominguez O, Machinena A, Martin-Mateos MA et al. Baseline specific IgE levels are useful to predict safety of oral immunotherapy in egg-allergic children. Clin Exp Allergy 2014;44:130–41

    Article  CAS  PubMed  Google Scholar 

  129. Brożek JL, Terracciano L, Hsu J, Kreis J, Compalati E, Santesso N et al. Oral immunotherapy for IgE-mediated cow’s milk allergy: a systematic review and meta-analysis. Clin Exp Allergy 2012;42:363–74

    Article  CAS  PubMed  Google Scholar 

  130. Calvani M, Giorgio V, Miceli Sopo S. Specific oral tolerance induction for food. A systematic review. Eur Ann Allergy Clin Immunol 2010;42:11–9

    CAS  PubMed  Google Scholar 

  131. Nurmatov U, Devereux G, Worth A, Healy L, Sheikh A. Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis. Br J Nutr 2014;111:12–22

    Article  CAS  PubMed  Google Scholar 

  132. Nurmatov U, Venderbosch I, Devereux G, Simons FE, Sheikh A. Allergen-specific oral immunotherapy for peanut allergy. Cochrane Database Syst Rev 2012;9:CD009014

    PubMed  Google Scholar 

  133. Yeung JP, Kloda LA, McDevitt J, Ben-Shoshan M, Alizadehfar R. Oral immunotherapy for milk allergy. Cochrane Database Syst Rev 2012;11:CD009542

    PubMed  Google Scholar 

  134. Staden U, Rolinck-Werninghaus C, Brewe F, Wahn U, Niggemann B, Beyer K. Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007;62:1261–9

    Article  CAS  PubMed  Google Scholar 

  135. Kopac P, Rudin M, Gentinetta T, Gerber R, Pichler C, Hausmann O et al. Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. Allergy 2012;67:280–5

    Article  CAS  PubMed  Google Scholar 

  136. Brockow K, Schallmayer S, Beyer K, Biedermann T, Fischer J, Gebert N et al. Effects of a structured educational intervention on knowledge and emergency management in patients at risk for anaphylaxis. Allergy 2015;70:227–35

    Article  CAS  PubMed  Google Scholar 

  137. Eller E, Bindslev-Jensen C. Clinical value of component-resolved diagnostics in peanut-allergic patients. Allergy 2013;68:190–4

    Article  CAS  PubMed  Google Scholar 

  138. Nicolaou N, Murray C, Belgrave D, Poorafshar M, Simpson A, Custovic A. Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. J Allergy Clin Immunol 2011;127:684–5

    Article  PubMed  Google Scholar 

  139. Klemans RJ, Broekman HC, Knol EF, Bruijnzeel-Koomen CA, Otten HG, Pasmans SG et al. Ara h 2 is the best predictor for peanut allergy in adults. J Allergy Clin Immunol Pract 2013;1:632–8 e1

    Article  PubMed  Google Scholar 

  140. Glaumann S, Nopp A, Johansson SG, Rudengren M, Borres MP, Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy 2012;67:242–7

    Article  CAS  PubMed  Google Scholar 

  141. Morita E, Matsuo H, Chinuki Y, Takahashi H, Dahlstrom J, Tanaka A. Food-dependent exercise-induced anaphylaxis — importance of omega-5 gliadin and HMW-glutenin as causative antigens for wheat-dependent exercise-induced anaphylaxis. Allergol Int 2009;58:493–8

    Article  CAS  PubMed  Google Scholar 

  142. Ocmant A, Mulier S, Hanssens L, Goldman M, Casimir G, Mascart F et al. Basophil activation tests for the diagnosis of food allergy in children. Clin Exp Allergy 2009;39:1234–45

    Article  CAS  PubMed  Google Scholar 

  143. Sato S, Tachimoto H, Shukuya A, Kurosaka N, Yanagida N, Utsunomiya T et al. Basophil activation marker CD203c is useful in the diagnosis of hen’s egg and cow’s milk allergies in children. Int Arch Allergy Immunol 2010;152 Suppl 1:54–61

    Article  PubMed  Google Scholar 

  144. Erdmann SM, Heussen N, Moll-Slodowy S, Merk HF, Sachs B. CD63 expression on basophils as a tool for the diagnosis of pollen-associated food allergy: sensitivity and specificity. Clin Exp Allergy 2003;33:607–14

    Article  CAS  PubMed  Google Scholar 

  145. Ebo DG, Hagendorens MM, Bridts CH, Schuerwegh AJ, De Clerck LS, Stevens WJ. Flow cytometric analysis of in vitro activated basophils, specific IgE and skin tests in the diagnosis of pollen-associated food allergy. Cytometry B Clin Cytom 2005;64:28–33

    Article  CAS  PubMed  Google Scholar 

  146. Ballmer-Weber BK, Weber JM, Vieths S, Wuthrich B. Predictive value of the sulfidoleukotriene release assay in oral allergy syndrome to celery, hazelnut, and carrot. J Investig Allergol Clin Immunol 2008;18:93–9

    CAS  PubMed  Google Scholar 

  147. Cerecedo I, Zamora J, Shreffler WG, Lin J, Bardina L, Dieguez MC et al. Map** of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol 2008;122:589–94

    Article  CAS  PubMed  Google Scholar 

  148. Jarvinen KM, Beyer K, Vila L, Chatchatee P, Busse PJ, Sampson HA. B-cell epitopes as a screening instrument for persistent cow’s milk allergy. J Allergy Clin Immunol 2002;110:293–7

    Article  CAS  PubMed  Google Scholar 

  149. Jarvinen KM, Chatchatee P, Bardina L, Beyer K, Sampson HA. IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow’s milk allergy. Int Arch Allergy Immunol 2001;126:111–8

    Article  CAS  PubMed  Google Scholar 

  150. Beyer K, Ellman-Grunther L, Jarvinen KM, Wood RA, Hourihane J, Sampson HA. Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts. J Allergy Clin Immunol 2003;112:202–7

    Article  CAS  PubMed  Google Scholar 

  151. Lin J, Bruni FM, Fu Z, Maloney J, Bardina L, Boner AL et al. A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay. J Allergy Clin Immunol 2012;129:1321–8 e5

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  152. Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA. Specificity of IgE antibodies to sequential epitopes of hen’s egg ovomucoid as a marker for persistence of egg allergy. Allergy 2007;62:758–65

    Article  CAS  PubMed  Google Scholar 

  153. Ayuso R, Sanchez-Garcia S, Lin J, Fu Z, Ibanez MD, Carrillo T et al. Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age. J Allergy Clin Immunol 2010;125:1286–93 e3.

    Article  CAS  PubMed  Google Scholar 

  154. Ayuso R, Sanchez-Garcia S, Pascal M, Lin J, Grishina G, Fu Z et al. Is epitope recognition of shrimp allergens useful to predict clinical reactivity? Clin Exp Allergy 2012;42:293–304

    Article  CAS  PubMed  Google Scholar 

  155. Ruppel E, Ay B, Boisguerin P, Dolle S, Worm M, Volkmer R. Identification of IgE binding to Api g 1-derived peptides. Chembiochem 2010;11:2283–93

    Article  CAS  PubMed  Google Scholar 

  156. Wang J, Sampson HA. Oral and sublingual immunotherapy for food allergy. Asian Pac J Allergy Immunol 2013;31:198–209

    PubMed  Google Scholar 

  157. European Medicines Agency, eds. DBV Technologies S.A. Open-label follow-up study of the VIPES study to evaluate long-term efficacy and safety of the Viaskin Peanut. 2014; https://www.clinicaltrialsregister.eu/ctr-search/search?query=2013-001754-10. Zugegriffen 31.07.2014

  158. European Medicines Agency, eds. DBV Technologies SA. A double-blind, placebo-controlled, randomized trial to study the Viaskin® Peanut’s efficacy and safety for treating peanut allergy in children and adults. 2012; https://www.clinicaltrialsregister.eu/ctr-search/search?query=2011-002550-32. Zugegriffen: 31.07.2014

  159. Leung DY, Sampson HA, Yunginger JW, Burks AW, Jr., Schneider LC, Wortel CH et al. Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med 2003;348:986–93

    Article  CAS  PubMed  Google Scholar 

  160. Schneider LC, Rachid R, LeBovidge J, Blood E, Mittal M, Umetsu DT. A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol 2013;132:1368–74

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  161. Mahler V, Glöckler A, Worm M, Spornraft-Ragaller P, Bauer A, Dickel H et al. Proteinkontaktdermatitis. Allergologie 2013;36:219–26

    Google Scholar 

  162. Nicholson PJ, Llewellyn D, English JS. Evidence-based guidelines for the prevention, identification and management of occupational contact dermatitis and urticaria. Contact dermatitis 2010;63:177–86

    Article  PubMed  Google Scholar 

  163. Mahler V. Chefs and food handlers. In: Johansen JD, Frosch PJ, Lepoittevin JP, eds. Contact dermatitis. 5. ed. Berlin — Heidelberg — New York: Springer; 2010. p. 853–64

    Google Scholar 

  164. Vester L, Thyssen JP, Menne T, Johansen JD. Consequences of occupational food-related hand dermatoses with a focus on protein contact dermatitis. Contact dermatitis 2012;67:328–33

    Article  PubMed  Google Scholar 

  165. Baur X, Heutelbeck A, Hölzel C, Kampen V von, Korn M, Kujath P et al. Prävention arbeitsbedingter obstruktiver Atemwegserkrankungen. 2011; http://www.awmf.org/leitlinien/detail/ll/002-025.html. Zugegriffen: 18.07.2014

  166. Raulf-Heimsoth M, Kespohl S, Liebers V, Rihs HP, Rozynek P, Sander I et al. Berufsbedingte Typ-I-Allergien — aktueller Stand. Allergo J 2009;18:538–50

    Google Scholar 

  167. Raulf-Heimsoth M, Kampen V van, Kespohl S, Sander I, Merget R, Bruning T. Inhalationsallergien am Arbeitsplatz. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 2012;55:363–72

    Article  CAS  Google Scholar 

  168. Barbuzza O, Guarneri F, Galtieri G, Gangemi S, Vaccaro M. Protein contact dermatitis and allergic asthma caused by Anisakis simplex. Contact dermatitis 2009;60:239–40

    Article  PubMed  Google Scholar 

  169. Matsuo H, Uemura M, Yorozuya M, Adachi A, Morita E. Identification of IgE-reactive proteins in patients with wheat protein contact dermatitis. Contact dermatitis 2010;63:23–30

    Article  CAS  PubMed  Google Scholar 

  170. Jappe U, Vieths S. Lupine, a source of new as well as hidden food allergens. Mol Nutr Food Res 2010;54: 113–26

    Article  CAS  PubMed  Google Scholar 

  171. Mahler V. Prick and intracutaneous testing and IgE testing. In: Rustemeyer T, Elsner P, John SM, Maibach HI, eds. Kanerva’s occupational dermatology. 2nd ed. Heidelberg — New York: Springer; 2012. p. 943–60

    Chapter  Google Scholar 

  172. Santa H, Saarela JT, Laatikainen R, Rautianen J, Virtanen T, Rytkonen M et al. A bovine dander allergen, comparative modeling, and similarities and differences in folding with related proteins. J Protein Chem 1998;17:657–62

    Article  CAS  PubMed  Google Scholar 

  173. Holzhauser T, Wackermann O, Ballmer-Weber BK, Bindslev-Jensen C, Scibilia J, Perono-Garoffo L et al. Soybean (Glycine max) allergy in Europe: Gly m 5 (beta-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. J Allergy Clin Immunol 2009;123:452–8

    Article  CAS  PubMed  Google Scholar 

  174. Quirce S, Polo F, Figueredo E, Gonzalez R, Sastre J. Occupational asthma caused by soybean flour in bakers — differences with soybean-induced epidemic asthma. Clin Exp Allergy 2000;30:839–46

    Article  CAS  PubMed  Google Scholar 

  175. Kuehn A, Swoboda I, Arumugam K, Hilger C, Hentges F. Fish allergens at a glance: variable allergenicity of parvalbumins, the major fish allergens. Front Immunol 2014;5:179

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  176. Dickel H, Bruckner T, Altmeyer P, Kunzlberger B. Allergie gegen Meeresfrüchte bei Köchen: Fallserie und Literaturübersicht. J Dtsch Dermatol Ges 2014;12:891–902

    PubMed  Google Scholar 

  177. Lopata AL, Jeebhay MF. Airborne seafood allergens as a cause of occupational allergy and asthma. Curr Allergy Asthma Rep 2013;13:288–97

    Article  CAS  PubMed  Google Scholar 

  178. Adisesh A, Robinson E, Nicholson PJ, Sen D, Wilkinson M. U.K. standards of care for occupational contact dermatitis and occupational contact urticaria. Br J Dermatol 2013;168:1167–75

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  179. Diepgen TL, Bernhard-Klimt C, Blome O, Brandenburg S, Dienstbach D, Drexler H et al. Bamberger Merkblatt: Begutachtungsempfehlungen für die Begutachtung von Haut- und Hautkrebserkrankungen. Teil I: Hauterkrankungen. Dermatol Beruf Umwelt 2008;56: 132–50

    Article  Google Scholar 

  180. Moscato G, Pala G, Barnig C, De Blay F, Del Giacco SR, Folletti I et al. EAACI consensus statement for investigation of work-related asthma in non-specialized centres. Allergy 2012;67:491–501

    Article  CAS  PubMed  Google Scholar 

  181. Moscato G, Vandenplas O, Van Wijk RG, Malo JL, Perfetti L, Quirce S et al. EAACI position paper on occupational rhinitis. Respir Res 2009;10:16

    Article  PubMed Central  PubMed  Google Scholar 

  182. Kampen V van, Blay F de, Folletti I, Kobierski P, Moscato G, Olivieri M et al. EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies. Allergy 2013;68:580–4

    Article  PubMed  Google Scholar 

  183. Krogh G von, Maibach HI. The contact urticaria syndrome — an updated review. J Am Acad Dermatol 1981;5:328–42

    Article  Google Scholar 

  184. Zuberbier T, Aberer W, Brockow K, Grabbe J, Hamelmann E, Hartmann K et al. S3-Leitlinie Urtikaria. Teil 1: Klassifikation und Diagnostik der Urtikaria — deutschsprachige Version der internationalen S3-Leitlinie. Allergo J 2011;20:249–58

    Google Scholar 

  185. Kampen V van, Blay F de, Folletti I, Kobierski P, Moscato G, Olivieri M et al. Evaluation of commercial skin prick test solutions for selected occupational allergens. Allergy 2013;68:651–8

    Article  CAS  PubMed  Google Scholar 

  186. Mahler V, Drexler H. Berufsdermatologisch relevante Typ-I-Allergien. Hautarzt 2004;55:34–41

    Article  CAS  PubMed  Google Scholar 

  187. Nowak D, Diepgen TL, Drexler H. Zur Einschätzung der Minderung der Erwerbsfähigkeit infolge einer IgE-vermittelten Allergie mit Organmanifestation an Haut und Atemwegen. Pneumologie 2004;58:365–6

    Article  CAS  PubMed  Google Scholar 

  188. Skudlik C, Allmers H, John SM, Becker D, Dickel H, Geier J et al. Beurteilung der Auswirkungen einer Allergie gegenüber Naturgummilatex bei der Minderung der Erwerbsfähigkeit im Rahmen der BK 5101. Dermatol Beruf Umwelt 2010;58:54–60

    Article  Google Scholar 

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Worm M, Reese I, Ballmer-Weber B, Beyer K, Bischoff SC, Claßen M, Fischer PJ, Fuchs T, Huttegger I, Jappe U, Klimek L, Koletzko B, Lange L, Lepp U, Mahler V, Niggemann B, Rabe U, Raithel M, Saloga J, Schäfer C, Schnadt S, Schreiber J, Szépfalusi Z, Treudler R, Wagenmann M, Watzl B, Werfel T, Zuberbier T, Kleine-Tebbe J. Guidelines on the management of IgE-mediated food allergies. S2K-Guidelines of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Medical Association of Allergologists (AeDA), the German Professional Association of Pediatricians (BVKJ), the German Allergy and Asthma Association (DAAB), German Dermatological Society (DDG), the German Society for Nutrition (DGE), the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS), the German Society for Oto-Rhino-Laryngology, Head and Neck Surgery, the German Society for Pediatric and Adolescent Medicine (DGKJ), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Society for Pneumology (DGP), the German Society for Pediatric Gastroenterology and Nutrition (GPGE), German Contact Allergy Group (DKG), the Austrian Society for Allergology and Immunology (ÖGAI), German Professional Association of Nutritional Sciences (VDOE) and the Association of the Scientific Medical Societies Germany (AWMF). Allergo J Int 2015;24:256–93

Ein Erratum zu diesem Kapitel finden Sie unter http://dx.doi.org/10.1007/s15007-015-0983-8

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Worm, M., Reese, I., Ballmer-Weber, B. et al. Leitlinie zum Management IgE-vermittelter Nahrungsmittelallergien. Allergo J 24, 38–77 (2015). https://doi.org/10.1007/s15007-015-0929-1

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