Abstract
Drug-induced pauci-immune crescentic glomerulonephritis has been described with several agents, including propylthiouracil, minocycline, d-penicillamine, and hydralazine. We present the case of a 60-year-old man who presented with rapidly progressive glomerulonephritis in the setting of recent use of trimethoprim–sulfamethoxazole complicated by the development of the Stevens–Johnson syndrome, and was found to have biopsy-proven pauci-immune crescentic glomerulonephritis and undetectable anti-neutrophilic cytoplasmic antibodies. We review the existing literature on the potential association between sulfonamides and hypersensitivity polyangiitis.
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Hegde, S.S., Bijol, V. & Jaber, B.L. Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim–sulfamethoxazole. CEN Case Rep 5, 188–191 (2016). https://doi.org/10.1007/s13730-016-0222-5
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DOI: https://doi.org/10.1007/s13730-016-0222-5