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Mechanical and Cell-Adhesive Properties of Gelatin/Polyvinyl Alcohol Hydrogels and Their Application in Wound Dressing

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Abstract

Gelatin/polyvinyl alcohol (PVA) (g/P) porous hydrogels are chemically and physically crosslinked to evaluate the influence of the g/P weight ratio on the mechanical properties and cell adhesion behavior of the composite hydrogels. The degradation rate, pore size, and swelling rate of the g/P hydrogels decreased when the g/P ratio was lowered from 10/0 to 0/10 owing to the presence of PVA. Although the compressive strength increased with the increase in the PVA proportion in g/P hydrogels, no cell adhesion was observed in pure PVA due to the absence of ligands that bind to cell-surface receptors. Hydrogels with properties tailored for wound dressings can be obtained by adjusting the specific proportions of gelatin and PVA. We conclude that 5/5 and 7/3 g/P hydrogels can be applied as wound healing biomaterials because of their suitable mechanical properties, and their ability to facilitate rapid cell adhesion and proliferation.

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Acknowledgment

This research was supported by the Materials & Components Technology Development Program (Project No. 20003560), funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea).

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Authors and Affiliations

  1. Department of Biomedical Engineering, Daelim University, Anyang, 13916, Korea

    Heeseok Jeong & Deuk Yong Lee

  2. Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea

    Dae Hyeok Yang

  3. Department of Materials Science and Engineering, Korea Aerospace University, Goyang, 10540, Korea

    Yo-Seung Song

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  1. Heeseok Jeong
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Correspondence to Deuk Yong Lee.

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Jeong, H., Lee, D.Y., Yang, D.H. et al. Mechanical and Cell-Adhesive Properties of Gelatin/Polyvinyl Alcohol Hydrogels and Their Application in Wound Dressing. Macromol. Res. 30, 223–229 (2022). https://doi.org/10.1007/s13233-022-0027-7

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  • DOI: https://doi.org/10.1007/s13233-022-0027-7

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