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Clinical differences among racially diverse children with celiac disease

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Fig. 1

Data availability

All data generated or analyzed during this study are included in this published article. The authors report that some of the data herein have been shared previously in a virtual poster presentation at the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition 2021 meeting.

References

  1. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 2001;120:636–51.

    Article  CAS  Google Scholar 

  2. Choung R, Ditah I, Nadeau A, Rubio-Tapia A, Marietta E, Brantner T, et al. Trends and racial/ethnic disparities in gluten-sensitive problems in the United States: findings from the National health and nutrition examination surveys from 1988 to 2012. Am J Gastroenterol. 2015;110:455–61.

    Article  Google Scholar 

  3. Krigel A, Turner K, Makharia G, Green P, Genta R, Lebwohl B. Ethnic variations in duodenal villous atrophy consistent with celiac disease in the United States. Clin Gastroenterol Hepatol. 2016;14:1105–11.

    Article  Google Scholar 

  4. Ashtari S, Pourhoseingholi M, Rostami K, Asadzadeh Aghdaei H, Rostami-Nejad M, Busani L, et al. Prevalence of gluten-related disorders in Asia-Pacific region: a systematic review. J Gastrointestin Liver Dis. 2019;28:95–105.

    Article  Google Scholar 

  5. Makharia G, Verma A, Amarchand R, Bhatnagar S, Das P, Goswami A, et al. Prevalence of celiac disease in the northern part of India: a community based study. J Gastroenterol Hepatol. 2011;26:894–900.

    Article  Google Scholar 

  6. Sotelo Cruz N. Calderón de la Barca AM, Hurtado Valenzuela JG. Enfermedad celiaca en niños del noroeste de México: características clínicas de 24 casos [Celiac disease in children from the northwest of Mexico: clinical characteristics of 24 cases]. Rev Gastroenterol Mex. 2013;78:211–8.

    CAS  PubMed  Google Scholar 

  7. Ramirez-Cervantes K, Remes-Troche J, del Pilar MG, Romero V, Uscanga L. Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease. BMC Gastroenterol. 2015;15:4.

    Article  Google Scholar 

  8. Mager DR, Marcon M, Brill H, Liu A, Radmanovich K, Mileski H, et al. Adherence to the gluten-free diet and Health-related quality of life in an ethnically diverse pediatric population with celiac disease. J Pediatr Gastroenterol Nutr. 2018;66:941–8.

    Article  Google Scholar 

  9. Rajani S, Alzaben A, Shirton L, Persad R, Huynh H, Mager D, et al. Exploring anthropometric and laboratory differences in children of varying ethnicities with celiac disease. Can J Gastroenterol Hepatol. 2014;28:351–4.

    Article  Google Scholar 

  10. Husby S, Koletzko S, Korponay-Szabo I, Kurppa K, Mearin M, Ribes-Koninckx C, et al. European society paediatric gastroenterology, hepatology and nutrition guidelines for diagnosing coeliac disease 2020. J Pediatr Gastroenterol Nutr. 2020;70:141–56.

    Article  Google Scholar 

  11. Lakha F, Gorman DR, Mateos P. Name analysis to classify populations by ethnicity in public health: validation of Onomap in Scotland. Public Health. 2011;125:688–96.

    Article  CAS  Google Scholar 

  12. Centers for Disease Control and Prevention, National Center for Health Statistics. CDC growth charts: United States. http://www.cdc.gov/growthcharts/. Accessed May 30, 2000.

  13. Wingren CJ, Agardh D, Merlo J. Sex differences in coeliac disease risk: a Swedish sibling design study. Dig Liver Dis. 2012;44:909–13.

    Article  Google Scholar 

  14. U.S. Census Bureau. American Community Survey 1-year estimates. 2019; Available from: http://censusreporter.org/profiles/16000US4819000-dallas-tx/. Accessed October 13, 2021.

  15. Donaldson M, Firth S, Wimpee H, Leiferman K, Zone J, Horsley W, et al. Correlation of duodenal histology with tissue transglutaminase and endomysial antibody levels in pediatric celiac disease. Clin Gastroenterol Hepatol. 2007;5:567–73.

    Article  CAS  Google Scholar 

  16. Bhattacharya M, Lomash A, Sakhuja P, Dubey AP, Kapoor S. Clinical and histopathological correlation of duodenal biopsy with IgA anti-tissue transglutaminase titers in children with celiac disease. Indian J Gastroenterol. 2014;33:350–4.

    Article  Google Scholar 

  17. Singh P, Kurray L, Agnihotri A, Das P, Verma A, Sreenivas V, et al. Titers of anti-tissue transglutaminase antibody correlate well with severity of villous abnormalities in celiac disease. J Clin Gastroenterol. 2015;49:212–7.

    Article  CAS  Google Scholar 

  18. Hollowell J, Staehling N, Flanders W, Hannon W, Gunter E, Spencer C, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489–99.

    Article  CAS  Google Scholar 

  19. Elfström P, Montgomery SM, Kämpe O, Ekbom A, Ludvigsson JF. Risk of thyroid disease in individuals with celiac disease. J Clin Endocrinol Metab. 2008;93:3915–21.

    Article  Google Scholar 

  20. Hakanen M, Luotola K, Salmi J, Laippala P, Kaukinen K, Collin P. Clinical and subclinical autoimmune thyroid disease in adult celiac disease. Dig Dis Sci. 2001;46:2631–5.

    Article  CAS  Google Scholar 

  21. Ansaldi N, Palmas T, Corrias A, Barbato M, Rocco D’Altiglia M, Campanozzi A, et al. Autoimmune thyroid disease and celiac disease in children. J Pediatr Gastroenterol Nutr. 2003;37:63–6.

    Article  Google Scholar 

  22. Minelli R, Gaiani F, Kayali S, Francesco D, Fabiola F, Gioacchino L, et al. Thyroid and celiac disease in pediatric age: a literature review. Acta Biomed. 2018;89:11–6.

    CAS  PubMed  Google Scholar 

  23. Ch’ng C, Jones M, Kingham J. Celiac disease and autoimmune thyroid disease. Clin Med Res. 2007;5:184–92.

    Article  Google Scholar 

  24. Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004. Pediatrics. 2009;124:e362–70.

    Article  Google Scholar 

  25. Callaghan A, Moy R, Booth I, Debelle G, Shaw N. Incidence of symptomatic vitamin D deficiency. Arch Dis Child. 2006;91:606–7.

    Article  CAS  Google Scholar 

  26. Catassi C, Fasano A. Celiac disease as a cause of growth retardation in childhood. Curr Opin Pediatr. 2004;16:445–9.

    Article  Google Scholar 

  27. Gupta P, Gonzalez D, Waxman E. Forty percent of Black and hispanic parents of school-age children are food insecure. Urban Institute. 2020; Available from https://www.urban.org/sites/default/files/publication/103335/forty_percent_of_black_and_hispanic_parents_of_school_age_children_are_food_insecure.pdf. Accessed 13 Oct 2021.

  28. Nurminen S, Kivela L, Taavela J, Huhtala H, Mäki M, Kaukinen K, et al. Factors associated with growth disturbance at celiac disease diagnosis in children: a retrospective cohort study. BMC Gastroenterol. 2015;15:125.

    Article  Google Scholar 

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Acknowledgements

The authors would like to acknowledge Dr. Edaire Cheng for her study design recommendations and Dr. Bradley Barth for his guidance during the manuscript submission process.

Funding

The authors do not report any grant support.

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Authors and Affiliations

Authors

Contributions

KD: methodology, investigation, formal analysis, writing—original draft, and writing—review and editing; MA: conceptualization, methodology, formal analysis, writing—review and editing, and supervision.

Corresponding author

Correspondence to Kaley A. Desher.

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Conflict of interest

The authors have no conflicts of interest to disclose related to the research or assistance with manuscript preparation. No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

Ethical approval

The University of Texas Southwestern Institutional Review Board deemed the present study (IRB #STU 2019–1357) acceptable.

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Desher, K.A., Alkalay, M.J. Clinical differences among racially diverse children with celiac disease. World J Pediatr 18, 710–714 (2022). https://doi.org/10.1007/s12519-022-00596-4

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  • DOI: https://doi.org/10.1007/s12519-022-00596-4

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