Abstract
An asymptomatic 77-year-old man with intrahepatic bile duct dilation was referred to our hospital. Cholangiography revealed alternations between strictures and dilated segments from the right and left hepatic ducts to the lower bile ducts, with findings of a pruned tree, beaded, shaggy appearance, and diverticulum-like outpouching. Histopathology revealed abundant immunoglobulin G4 (IgG4)-positive plasma cells (> 10 per high-power field) with an IgG4/IgG-positive cell ratio of 40–50%. After 2 weeks of steroid therapy, the cholangiography markedly improved. Because the cholangiographic findings resembled those of primary sclerosing cholangitis, steroid therapy proved useful in differentiating IgG4-related sclerosing cholangitis from primary sclerosing cholangitis.
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References
Culver EL, Chapman RW. IgG4-related hepatobiliary disease: an overview. Nat Rev Gastroenterol Hepatol. 2016;13:601–12.
Graham RPD, Smyrk TC, Chari ST, et al. Isolated IgG4-related sclerosing cholangitis: a report of 9 cases. Hum Pathol. 2014;45:1722–9.
Kemp W, Majeed A, Mitchell J, et al. Management, outcomes and survival of an Australian IgG4-SC cohort: the MOSAIC study. Liver Int. 2021;41:2934–43.
Isayama H, Tazuma S, Kokudo N, et al. Clinical guidelines for primary sclerosing cholangitis 2017. J Gastroenterol. 2018;53:1006.
Elvevi A, Laffusa A, Scaravaglio M, et al. Clinical treatment of cholangiocarcinoma: an updated comprehensive review. Ann Hepatol. 2022;27:100737.
Naitoh I, Nakazawa T. Endoscopic retrograde cholangiopancreatography and intraductal ultrasonography in the diagnosis of autoimmune pancreatitis and IgG4-related sclerosing cholangitis. J Med Ultrason. 2021;48:573–80.
Nakazawa T, Kamisawa T, Okazaki K, et al. Clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2020: (revision of the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012). J Hepatobiliary Pancreat Sci. 2021;28:235–42.
Matsumoto R, Miura S, Kanno A, et al. IgG4-related sclerosing cholangitis mimicking cholangiocarcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Intern Med. 2020;59:945–50.
Naitoh I, Kamisawa T, Tanaka A, et al. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: comparison of cases with and without autoimmune pancreatitis in a large cohort. Dig Liver Dis. 2021;53:1308–14.
Naitoh I, Nakazawa T, Ohara H, et al. Endoscopic transpapillary intraductal ultrasonography and biopsy in the diagnosis of IgG4-related sclerosing cholangitis. J Gastroenterol. 2009;44:1147–55.
Tanaka A. IgG4-related sclerosing cholangitis and primary sclerosing cholangitis. Gut Liver. 2019;13:300.
Nakazawa T, Ohara H, Sano H, et al. Schematic classification of sclerosing cholangitis with autoimmune pancreatitis by cholangiography. Pancreas. 2006;32:229.
Naitoh I, Nakazawa T, Hayashi K, et al. Comparison of intraductal ultrasonography findings between primary sclerosing cholangitis and IgG4-related sclerosing cholangitis. J Gastroenterol Hepatol. 2015;30:1104–9.
Itoi T, Kamisawa T, Igarashi Y, et al. The role of peroral video cholangioscopy in patients with IgG4-related sclerosing cholangitis. J Gastroenterol. 2013;48:504–14.
Navaneethan U, Hasan MK, Lourdusamy V, et al. Single-operator cholangioscopy and targeted biopsies in the diagnosis of indeterminate biliary strictures: a systematic review. Gastrointest Endosc. 2015;82:608.
Lübbe J, Arnelo U, Lundell L, et al. ERCP-guided cholangioscopy using a single-use system: nationwide register-based study of its use in clinical practice. Endoscopy. 2015;47:802–7.
Ghazale A, Chari ST, Zhang L, et al. Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy. Gastroenterology. 2008;134:706–15.
Kawakami H, Zen Y, Kuwatani M, et al. IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vater’s ampulla and the bile duct. J Gastroenterol Hepatol. 2010;25:1648–55.
Navaneethan U, Njei B, Lourdusamy V, et al. Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures: a systematic review and meta-analysis. Gastrointest Endosc. 2015;81:168.
Aoki T, Ohno E, Ishikawa T, et al. Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma. BMC Gastroenterol. 2022;22:329.
Kawashima H, Ohno E, Ishikawa T, et al. Endoscopic management of perihilar cholangiocarcinoma. Dig Endosc. 2022;34:1147–56.
Yamamoto K, Tsuchiya T, Itoi T, et al. Evaluation of novel slim biopsy forceps for diagnosis of biliary strictures: single-institutional study of consecutive 360 cases (with video). World J Gastroenterol. 2017;23:6429–36.
Kubota K, Kamisawa T, Nakazawa T, et al. Steroid therapy still plays a crucial role and could serve as a bridge to the next promising treatments in patients with IgG4-related sclerosing cholangitis: results of a Japanese Nationwide Study. J Hepatobiliary Pancreat Sci. 2022;29:884–97.
Giljaca V, Poropat G, Stimac D, et al. Glucocorticosteroids for primary sclerosing cholangitis. Cochrane Database Syst Rev. 2010. https://doi.org/10.1002/14651858.CD004036.pub3.
Moon SH, Kim MH, Lee JK, et al. Development of a scoring system for differentiating IgG4-related sclerosing cholangitis from primary sclerosing cholangitis. J Gastroenterol. 2017;52:483–93.
Iwasaki S, Kamisawa T, Koizumi S, et al. Assessment in steroid trial for IgG4-related sclerosing cholangitis. Adv Med Sci. 2015;60:211–5.
Tomiyama T, Uchida K, Matsushita M, et al. Comparison of steroid pulse therapy and conventional oral steroid therapy as initial treatment for autoimmune pancreatitis. J Gastroenterol. 2011;46:696–704.
Ikeura T, Tomiyama T, Takaori A, et al. Long-term outcomes after steroid pulse therapy in patients with type 1 autoimmune pancreatitis. Intern Med. 2023;15(62):2931–40.
Kamisawa T, Nakazawa T, Tazuma S, et al. Clinical practice guidelines for IgG4-related sclerosing cholangitis. J Hepatobiliary Pancreat Sci. 2019;26:9.
Cho SH, Song TJ, Park J-S, et al. Comparison of the long-term outcomes between proximal and distal IgG4-related sclerosing cholangitis: a multicenter cohort study. J Gastroenterol Hepatol. 2023;38:648–55.
Song J, Li Y, Bowlus CL, et al. Cholangiocarcinoma in patients with primary sclerosing cholangitis (PSC): a comprehensive review. Clin Rev Allergy Immunol. 2020;58:134–49.
Trilianos P, Agnihotri A, Ucbilek E, et al. Greater biosynthetic liver dysfunction in primary sclerosing cholangitis suggests co-existent or impending cholangiocarcinoma. J Clin Transl Hepatol. 2016;4:1–4.
Villard C, Friis-Liby I, Rorsman F, et al. Prospective surveillance for cholangiocarcinoma in unselected individuals with primary sclerosing cholangitis. J Hepatol. 2023;78:604–13.
Hirano K, Tada M, Sasahira N, et al. Incidence of malignancies in patients with IgG4-related disease. Intern Med. 2014;53:171–6.
Tanaka A, Tazuma S, Okazaki K, et al. Clinical features, response to treatment, and outcomes of IgG4-related sclerosing cholangitis. Clin Gastroenterol Hepatol. 2017;15:920-926.e3.
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Takada, Y., Ishikawa, T., Yamao, K. et al. An atypical case of isolated immunoglobulin G4-related sclerosing cholangitis with a cholangiogram resembling primary sclerosing cholangitis. Clin J Gastroenterol 17, 338–344 (2024). https://doi.org/10.1007/s12328-023-01903-w
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DOI: https://doi.org/10.1007/s12328-023-01903-w