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Invasive Candidiasis in Liver Transplant Recipients: A Review

  • Fungal Infections in Transplantation (S Shoham, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review summarizes the literature on invasive candidiasis (IC) in liver transplant recipients (LTRs) regarding diagnostic strategies, treatment, and prophylaxis.

Recent Findings

Recent literature on IC has expanded and refined definitions of risk factors for IC in LTRs. We discuss increasing rates of resistance among candida species and new antifungals. Diagnostic modalities continue to decrease time to initiation of empiric antifungals, which may impact outcomes.

Summary

A well-documented host of risk factors for IC may allow for targeted prophylaxis, while minimizing exposure to antifungal medications. Further research on minimum effective duration of treatment and prophylaxis is needed to combat resistance.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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SA: funding by the Cystic Fibrosis Foundation and NIH/NCATS

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  1. Division of Infectious Diseases and Global Public Health, University of California, San Diego, 4510 Executive Drive, MC7745, La Jolla, CA, 92021, USA

    Rachel Sigler & Saima Aslam

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  1. Rachel Sigler
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  2. Saima Aslam
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Correspondence to Saima Aslam.

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SA: funding by the Cystic Fibrosis Foundation and NIH/NCATs. Consultant for Merck (honoraria paid), Gilead (honoraria paid), and BioMx (unpaid).

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This article is part of the Topical Collection on Fungal Infections in Transplantation

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Sigler, R., Aslam, S. Invasive Candidiasis in Liver Transplant Recipients: A Review. Curr Fungal Infect Rep 15, 151–161 (2021). https://doi.org/10.1007/s12281-021-00426-6

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