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Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism

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Abstract

Plastic pollution has become a non-negligible global pollution problem. Nanoplastics (NP) can reach the bone marrow with blood circulation and develop hematotoxicity, but potential mechanisms and prevention strategies are lacking. Here, we report the biological distribution of NP particles in the bone marrow of mice and hematopoietic toxicity after exposure to 60 µg of 80 nm NP for 42 days. NP exposure inhibited the capability of bone marrow hematopoietic stem cells to renew and differentiate. Notably, probiotics and melatonin supplementation significantly ameliorated NP-induced hematopoietic damage, and the former was superior to the latter. And interestingly, melatonin and probiotic interventions may involve different microbes and metabolites. After melatonin intervention, creatine showed a stronger correlation with NP-induced gut microbiota disorders. In contrast, probiotic intervention reversed the levels of more gut microbes and plasma metabolites. Of these, threonine, malonylcarnitine, and 3-hydroxybutyric acid might be potential performers in the regulation of hematopoietic toxicity by gut microbes, as they had a more significant relationship with the identified microbes. In conclusion, supplementation with melatonin or probiotics may be two candidates to prevent hematopoietic toxicity attributable to NP exposure. Also, the multi-omics results may lay the foundation for future investigations into in-depth mechanisms.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (Nos. 82073520 and 81773397), the Bei**g Natural Science Program and Sci-entific Research Key Program of Bei**g Municipal Commission of Ed-ucation (No. KZ201810025032), and the Support Project of High-level Teachers in Bei**g Municipal Universities in the Period of 13th Five-year Plan (No. CIT&TCD 20170323).

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  1. Lei Zhang and Jiaru **g contributed equally to this work.

Authors and Affiliations

  1. Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Bei**g, 100069, China

    Lei Zhang, Jiaru **g, Lin Han, Ziyan Liu, **gyu Wang, Wei Zhang & Ai Gao

  2. Bei**g Key Laboratory of Environmental Toxicology, Capital Medical University, Bei**g, 100069, China

    Ai Gao

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  1. Lei Zhang
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Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism

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Zhang, L., **g, J., Han, L. et al. Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism. Nano Res. 16, 2885–2894 (2023). https://doi.org/10.1007/s12274-022-5032-9

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