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BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy

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Abstract

Cisplatin (CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence rate. Synergy therapy has been proven as a potent approach to minimize recurrence and achieve enhanced treatment effects. Herein, chemotherapy drug CDDP is assembled with the photothermal-Fenton agent of bovine serum albumin (BSA) stabilized gallic acid-functionalized iron nanoparticles (GA-Fe NPs) to achieve chemo/chemodynamic synergistic cascade oncotherapy. The Pt-GA-Fe NPs can be utilized to generate H2O2 via the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) in the tumor microenvironment (TME), which would then greatly boost H2O2-depending chemodynamic therapy (CDT). The generated cytotoxic reactive oxygen species (hydroxyl radicals, ·OH) and the depletion of glutathione (GSH) would further promote CDDP-induced DNA damage. Moreover, benefiting from the absorption in the near-infrared (NIR) region, Pt-GA-Fe NPs exhibit excellent photothermal conversion efficiency (η = 45.5%) and allow photoacoustic imaging (PAI) guided photothermal therapy (PTT). In vitro and in vivo experiments show that synergy therapy can effectively kill cancer cells and successfully cure cancer without systemic toxicity. The work highlights a new type of therapeutic agent based on CDDP with the ability of H2O2 self-generation, thermal responsiveness, and enhanced CDT effects for applications in cancer therapy.

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Acknowledgements

The work was supported by National Natural Science Foundation (NNSF) of China (Nos. 61775095, 61935004, and 51803091), Jiangsu Province Policy Guidance Plan (No. BZ2019014), Natural Science Foundation of Jiangsu Province (No. BK20200092), Natural Science Foundation of Shandong Province (No. ZR2020KB018), and “Taishan scholars” construction special fund of Shandong Province.

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Authors and Affiliations

  1. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nan**g Tech University (Nan**gTech), Nan**g, 211816, China

    Nan Yang, Tian Zhang, Changyu Cao, **jun Shao, Xuejiao Song & **aochen Dong

  2. School of Physical Science and Information Technology, Liaocheng University, Liaocheng, 252059, China

    Wenjun Wang

  3. Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, 310013, China

    Genxiang Mao & **aozhou Mou

  4. Clinical Research Institute, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, China

    **aozhou Mou

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  1. Nan Yang
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  2. Tian Zhang
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  7. Wenjun Wang
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  8. **aozhou Mou
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  9. **aochen Dong
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Correspondence to Xuejiao Song, **aozhou Mou or **aochen Dong.

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Yang, N., Zhang, T., Cao, C. et al. BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy. Nano Res. 15, 2235–2243 (2022). https://doi.org/10.1007/s12274-021-3758-4

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  • DOI: https://doi.org/10.1007/s12274-021-3758-4

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