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Antibacterial Activity of Prenylated Flavonoids Isolated from Hop against Fish Pathogens Streptococcus iniae and Vibrio vulnificus

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Abstract

Reducing fish pathogenic bacteria outbreak is important as it results in economic losses in aquaculture. Antibiotics are an inevitable tool to control the pathogenic bacteria outbreak. However, the authorities are taking more regulations to prevent the emergence of drug-resistant strain development. Alternative materials to be employed for the purpose are needed from natural sources. In this research, we explored the antibacterial activity of natural products derived from hop against fish pathogenic strains Streptococcus iniae and Vibrio vulnificus. Antimicrobial activities of nine separates from hops were tested against S. iniae and V. vulnificus and identified. Xanthohumol (1) showed strongest antibacterial property against S. iniae. In addition, desmethylxanthohumol (4) and 8-prenylnaringenin (5) showed antibacterial against both of the tested pathogen strains. Antibacterial compounds were all prenylated flavonoids, and these might be used as index components for development of feed additives for fish in aquaculture.

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Acknowledgements

This research was supported by the grants from the National Research Foundation of Korea (NRF-2019R1I1A1A01044151 & NRF-2021R1F1A1061707) and a project to train professional personnel in biological materials by the Ministry of Environment

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  1. Mijeong Lee and Jeonghee Lee contributed equally to this work.

Authors and Affiliations

  1. School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, 41566, Korea

    Mijeong Lee, Ja Min Kim & Dongyup Hahn

  2. Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan, 49112, Korea

    Jeonghee Lee & Inho Yang

  3. Institute of Agricultural Science and Technology, Kyungpook National University, Daegu, 41566, Korea

    Ja Min Kim & Dongyup Hahn

  4. School of Bio-industrial Machinery Engineering, Kyungpook National University, Daegu, 41566, Korea

    Dong-Hyuck Hong

  5. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Korea

    Jungwook Chin

  6. Department of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, Korea

    Hiyoung Kim

  7. Department of Food Biotechnology, Dong-A University, Busan, 49315, Korea

    Joon-Goo Lee

  8. Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Korea

    Sang-Jip Nam

  9. Department of Integrative Biotechnology, Kyungpook National University, Daegu, 41566, Korea

    Dongyup Hahn

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  1. Mijeong Lee
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Correspondence to Inho Yang or Dongyup Hahn.

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Lee, M., Lee, J., Kim, J.M. et al. Antibacterial Activity of Prenylated Flavonoids Isolated from Hop against Fish Pathogens Streptococcus iniae and Vibrio vulnificus. Biotechnol Bioproc E 27, 361–369 (2022). https://doi.org/10.1007/s12257-021-0247-2

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