SpringerLink
Log in

Performances and Biocompatibility of Prepared pH-Sensitive Cotton/Polyamide 6 Medical Dressings Dyed with Halochromic Dyes

  • Published:
Fibers and Polymers Aims and scope Submit manuscript

Abstract

A natural pH-sensitive dye, curcumin, and a synthetic pH-sensitive dye, Bromothymol blue, were successfully applied on cotton/polyamide 6 medical dressings. The work addresses two different topics: on the one hand the dyeing process of the medical devices; on the other hand, the evaluation of the dyed medical dressing biocompatibility. Different dye concentrations were tested to find the best dye exhaustion and dye fastness to washing and perspiration. The halochromic test evidenced a pH sensitivity in a range of pH from 5.5 to 8.0 and 8.5. These properties confirmed their possible usage as potential pH textile sensors in the control of skin diseases. The last sections examine the biocompatibility of the prepared medical devices with human skin. MTT assay on in vitro cultures of human epithelial cells (HaCaT keratinocytes) was performed to test the cytotoxicity. In vitro permeation studies with Franz cells were performed as well to evaluate the dye potential accumulation in the skin layers. No cytotoxicity was detected as well as no dye permeation through the skin layers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. W. Fluhr and P. M. Elias, Exog. Dermatol., 1, 163 (2002).

    Article  CAS  Google Scholar 

  2. J. R. Yu, J. Navarro, J. C. Coburn, B. Mahadik, J. Molnar, J. H. Holmes IV, A. J. Nam, and J. P. Fisher, Adv. Healthc. Mater., 8, 1801471 (2019).

    Article  CAS  Google Scholar 

  3. N. Garcia Bartels, R. Scheufele, F. Prosch, T. Schink, H. Proquitté, R. R. Wauer, and U. Blume-Peytavi, Pediatr. Dermatol., 27, 1 (2010).

    Article  PubMed  Google Scholar 

  4. I. H. Blank, J. Invest. Dermatol., 2, 75 (1938).

    Article  Google Scholar 

  5. D. J. Panther and S. E. Jacob, J. Clin. Med., 5, 970 (2015).

    Article  CAS  Google Scholar 

  6. L. Liu, X. Li, M. Nagao, A. L. Elias, R. Narain, and H. J. Chung, Polymer, 9, 558 (2017).

    Article  CAS  Google Scholar 

  7. M. H. Schmid-Wendtner and H. C. Korting, Skin Pharmacol. Physiol., 19, 296 (2006).

    Article  PubMed  Google Scholar 

  8. S. L. Percival, S. McCarty, J. A. Hunt, and E. J. Woods, Wound Repair Regen., 22, 174 (2014).

    Article  PubMed  Google Scholar 

  9. G. Gethin, Wounds UK, 3, 52 (2007).

    Google Scholar 

  10. J. Dissemond, M. B. T. Witthoff, D. Haberer, and M. Goos, Der Hautartzt., 54, 959 (2003).

    Article  CAS  Google Scholar 

  11. H. Nagase, R. Visse, and G. Murphy, Cardiovas. Res., 69, 562 (2006).

    Article  CAS  Google Scholar 

  12. S. H. Kuo, C. J. Shen, C. F. Shen, and C. M. Cheng, Diagnostics, 10, 107 (2020).

    Article  CAS  PubMed Central  Google Scholar 

  13. L. A. Schneider, A. Korber, S. Grabbe, and J. Dissemond, Arch. Dermatol. Res., 298, 413 (2007).

    Article  PubMed  Google Scholar 

  14. C. Hwa, E. A. Bauer, and D. E. Cohen, Dermatol. Ther., 24, 464 (2011).

    Article  PubMed  Google Scholar 

  15. M. L. Zamora, J. M. Dominguez, R. M. Trujillo, C. B. Goy, M. A. Sanchez, and R. E. Madrid, Sens. Actuators, B, 260, 601 (2018).

    Article  CAS  Google Scholar 

  16. P. Mostafalu, A. Tamayol, R. Rahimi, M. Ochoa, A. Khalilpour, G. Kiaee, I. K. Yazdi, S. Bagherifard, M. R. Dokmeci, B. Ziaie, S. R. Sonkusale, and A. Khademhosseini, Small, 14, 1703509 (2018).

    Article  CAS  Google Scholar 

  17. M. Caldara, C. Colleoni, E. Guido, V. Re, and G. Rosace, Sens Actuators B, 222, 213 (2016).

    Article  CAS  Google Scholar 

  18. Y. Hattori, L. Falgout, W. Lee, S. Y. Jung, E. Poon, J. W. Lee, I. Na, A. Geisler, D. Sadhwani, Y. Zhang, Y. Su, X. Wang, Z. Liu, J. **a, H. Cheng, R. C. Webb, A. P. Bonifas, P. Won, J. W. Jeong, K. I. Jang, Y. M. Song, B. Nardone, M. Nodzenski, J. A. Fan, Y. Huang, D. P. West, A. S. Paller, M. Alam, W. H. Yeo, and J. A. Rogers, Adv. Healthc. Mater., 3, 1597 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Y. Liang, J. He, and B. Guo, ACS Nano, 15, 12687 (2021).

    Article  CAS  Google Scholar 

  20. J. Qu, X. Zhao, Y. Liang, T. Zhang, P. X. Ma, and B. Guo, Biomaterials, 183, 185 (2018).

    Article  CAS  PubMed  Google Scholar 

  21. S. Lykidou, M. Pashou, E. Vouvoudi, and N. Nikolaidis, Fiber. Polym., 22, 3336 (2021).

    Article  CAS  Google Scholar 

  22. Z. Liu, F. Luo, and T. Chen, Anal. Chim. Acta, 5, 10 (2004).

    Google Scholar 

  23. L. Van der Schueren and K. De Clerck, Text. Res. J., 80, 590 (2010).

    Article  CAS  Google Scholar 

  24. K. **e, A. Gao, C. Li, and M. Li, Sens Actuators B, 204, 167 (2014).

    Article  CAS  Google Scholar 

  25. F. Truffa Giachet, C. Vineis, D. O. Sanchez Ramirez, R. A. Carletto, A. Varesano, and G. Mazzuchetti, Fiber. Polym., 18, 720 (2017).

    Article  CAS  Google Scholar 

  26. S. Jareansin, P. Sukaam, and B. Kusuktham, Polym. Bull., 76, 4507 (2019).

    Article  CAS  Google Scholar 

  27. T. Salem, F. Simon, A. A. El-Sayed, and M. Salama, Fiber. Polym., 18, 731 (2017).

    Article  CAS  Google Scholar 

  28. T. De Meyer, I. Steyaert, K. Hemelsoet, R. Hoogenboom, V. Van Speybroeck, and K. De Clerck, Dyes Pigm., 124, 249 (2016).

    Article  CAS  Google Scholar 

  29. D. Massella, M. Argenziano, A. Ferri, J. Guan, S. Giraud, R. Cavalli, and A. A. Barresi, Pharmaceutics, 11, 8 (2019).

    Article  CAS  Google Scholar 

  30. L. Van der Schueren and K. De Clerck, Color Technol., 128, 82 (2012).

    Article  CAS  Google Scholar 

  31. A. A. Arafa, A. A. Nada, A. Y. Ibrahim, P. Sajkiewicz, M. K. Zahran, and O. A. Hakeim, Int. J. Biol. Macromol., 182, 1820 (2021).

    Article  CAS  PubMed  Google Scholar 

  32. K. L. Brocklesby, S. C. Johns, A. E. Jones, D. Sharp, and R. B. Smith, Medical Hypoteses, 80, 3 (2013).

    Google Scholar 

  33. P. Kopponen, M. Asikainen, R. Törrönen, K. Klemola, J. Liesivuori, and S. Kärenlampi, ATLA Altern. Lab. Anim., 5, 539 (1997).

    Article  Google Scholar 

  34. R. Räisänen, A. Primetta, S. Nikunen, U. Honkalampi, H. Nygren, Berghe, J. M. Pihlava, I. V. Berghe, and A. von Wright, Antibiotics, 9, 266 (2020).

    Article  PubMed Central  CAS  Google Scholar 

  35. R. Peila, A. Varesano, C. Vineis, V. Bobba, J. Bobba, A. Piriou, and M. Barazzotto, Color. Technol., 137, 123 (2021).

    Article  CAS  Google Scholar 

  36. A. D. Broadbent, “Basic Principles of Textile Coloration”, Society of Dyers and Colourists, West Yorkshire, England, 2001.

    Google Scholar 

  37. M. Espinosa-Jiménez, R. Padilla-Weigand, A. Ontiveros-Ortega, R. Perea-Carpio, M. M. Ramos-Tejada, and E. Chibowski, J. Adhes. Sci. Technol., 16, 303 (2002).

    Article  Google Scholar 

  38. L. Van der Schueren, K. Hemelsoet, V. Van Speybroeck, and K. De Clerck, Dyes Pigm., 94, 443 (2012).

    Article  CAS  Google Scholar 

  39. M. Shabbir, A. Shakeel, and N. S. Javed, “Frontiers of Textile Materials: Polymers, Nanomaterials, Enzymes, and Advanced Modification Techniques”, Scrivener Publishing LLC, 2020.

  40. Y. A. Youseff, M. M. Kamel, M. S. Taher, N. F. Ali, and S. A. Abd El Megede, J. Suadi. Chemic Soc., 18, 220 (2014).

    Google Scholar 

  41. P. Roshan, S. Conxita, and E. Pilar, Colloids Surf., A, 253, 175 (2005).

    Article  CAS  Google Scholar 

  42. L. Van Der Schueren, K. De Clerck, G. Brancatelli, G. Rosace, E. Van Damme, and W. De Vos, Sens. Actuators, B, 162, 27 (2012).

    Article  CAS  Google Scholar 

  43. M. Bernard, E. Jubeli, M. D. Pungente, and N. Yagoubi, Biomater Sci., 6, 2025 (2018).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The work has been funded by Fondazione Cassa di Risparmio of Biella- Project BIOBENS - “Biocompatibilità di bendaggi sensibili al pH”.

A special thank goes to Prof. Ferrero Franco for his advice and suggestions.

Author information

Authors and Affiliations

  1. CNR-STIIMA, Institute of Intelligent Industrial Techmologies and Systems for Advanced Manufacturing, Biella, 13900, Italy

    Roberta Peila, Alessio Varesano, Claudia Vineis & Cinzia Tonetti

  2. UNITO, Department of Drug Science and Technology, Torino, 10125, Italy

    Roberta Cavalli & Monica Argenziano

  3. Health and Textile Association, Biella, 13900, Italy

    Barbara Cravello

Authors
  1. Roberta Peila
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alessio Varesano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claudia Vineis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roberta Cavalli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Monica Argenziano
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Barbara Cravello
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Cinzia Tonetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roberta Peila.

Ethics declarations

The author declares that there are no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Peila, R., Varesano, A., Vineis, C. et al. Performances and Biocompatibility of Prepared pH-Sensitive Cotton/Polyamide 6 Medical Dressings Dyed with Halochromic Dyes. Fibers Polym 23, 2123–2131 (2022). https://doi.org/10.1007/s12221-022-4990-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12221-022-4990-6

Keywords

Search

Navigation