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Amniotic Product Treatments: Clinical and Basic Science Evidence

  • Stem Cells in Orthopaedic Surgery (J Dragoo and KJ Jones, Section Editors)
  • Published:
Current Reviews in Musculoskeletal Medicine Aims and scope Submit manuscript

Abstract

Purpose of Review

Orthobiologics, including amniotic products, have been gaining interest in the past decade for the treatment of various orthopedic conditions including osteoarthritis. However, the use of biologics is varied and is currently available with minimal oversight or regulation. This review will assess the current state of research that utilizes amniotic products both in vitro and in vivo.

Recent Findings

Amniotic tissue derivatives have been shown to have positive effects in animal models for a variety of conditions. Clinical trials are limited with mixed outcomes, yet some recent studies suggest the rationale for continued investigation.

Summary

While amniotic products appear promising in numerous animal studies, human clinical trials are still lacking. Future studies are needed to assess whether amniotic products have a role in the treatment of osteoarthritis and other orthopedic pathologies.

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Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University Medical Center, 1611 W. Harrison St, Suite 300, Chicago, IL, 60612, USA

    Hailey P. Huddleston, Matthew R. Cohn, Eric D. Haunschild, Stephanie E. Wong & Adam B. Yanke

  2. Knee Preservation and Cartilage Restoration Center, OrthoIndy, Indianapolis, IN, USA

    Jack Farr

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Corresponding author

Correspondence to Adam B. Yanke.

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Conflict of Interest

Hailey P. Huddleston, Matthew Cohn, Eric Haunschild, and Stephanie E. Wong declare no conflicts of interest.

Jack Farr reports research support from Active Implants, Arthrex, Inc., Episurf, Fidia Pharma, JRF Ortho, Moximed, Inc., Novartis, Inc., Organogenesis, Samumed, Vericel, and ZimmerBiomet; paid consultant for Aesculap/B.Braun, Arthrex, Inc., Cartiheal, Cook Biotech, Inc., Exactech, Moximed, Inc., Organogenesis, Regentis, Samumed, Inc., Vericel, and ZKR Orthopedics, Inc.; royalties from Arthrex, Inc., Biopoly, LLC, Organogenesis, Springer, and Thieme Medical Publishers, Inc.; stock/stock options for MedShape, Inc. and Ortho Regenerative Tech, Inc.; and editorial board appointments to the American Journal of Orthopedics and Cartilage outside the submitted work.

Adam B. Yanke reports research support from Arthrex, Inc., Organogenesis, and Vericel; and paid consultant for JRF Ortho, Olympus, Patient IQ, Smith & Nephew, and Sparta Biomedical.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki Declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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Huddleston, H.P., Cohn, M., Haunschild, E. et al. Amniotic Product Treatments: Clinical and Basic Science Evidence. Curr Rev Musculoskelet Med 13, 148–154 (2020). https://doi.org/10.1007/s12178-020-09614-2

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  • DOI: https://doi.org/10.1007/s12178-020-09614-2

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