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Blastoid Mantle Cell Lymphoma of the Palate: Report of a Rare Aggressive Entity and Review of the Literature

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Abstract

Mantle cell lymphoma (MCL) is a well-defined, non-Hodgkin lymphoma of B-cell origin displaying diverse morphological phenotypes and variable disease course. The World Health Organization recognizes two aggressive histopathologic variants of this type of lymphoma: pleomorphic and blastoid MCL. To date, only few cases of MCL affecting the oral cavity have been reported. Additionally, the involvement of the oral and maxillofacial area by aggressive MCL subsets is considered extremely rare with only two patients reported in the English language literature to the best of our knowledge. Herein, we describe a 69 year-old male with a prior history of MCL of the right lateral pharyngeal wall develo** a recurrent lesion extending to the palatal mucosa as diffuse ulceration and exhibiting histomorphological features of blastoid MCL. We also review the pertinent literature with emphasis on the diagnostic challenges and distinction between the different MCL variants.

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Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Greece.

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Acknowledgements

We would like to thank Dr. Savvas Titsinides for his contribution to patient’s diagnosis and management.

Funding

The authors did not receive support from any organization for the submitted work. No funds, grants, or other support was received.

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Authors and Affiliations

  1. Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon St., Goudi, 11527, Athens, Greece

    Maria Georgaki, Vasileios Ionas Theofilou, Efstathios Pettas, Evangelia Piperi, Eleana Stoufi & Nikolaos G. Nikitakis

  2. Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, USA

    Vasileios Ionas Theofilou

  3. First Propaedeutic Department of Internal Medicine “Laiko” Hospital, Medical School, University of Athens, Athens, Greece

    Panayiotis Panayiotidis

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  1. Maria Georgaki
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Contributions

All authors contributed to the study conception and design. All authors read and approved the final manuscript. Conceptualization: MG, VIT, NGN; Methodology: MG, VIT, NGN; Formal analysis and investigation: MG, VIT, NGN; Writing—original draft preparation: MG, VIT, EP; Writing—review and editing: EP, PP, NGN; Supervision: NGN.

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Correspondence to Maria Georgaki.

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The authors have no conflicts of interest to declare that are relevant to the content of this article.

Ethical Approval

Ethics approval was waived by the local Ethics Committee of School of Dentistry, National and Kapodistrian University of Athens, Greece in view of the retrospective nature of the study and the fact that all procedures were part of the routine care, based on institutional regulations.

Informed Consent

No informed consent was obtained due to retrospective nature of the case and since only intra-oral images and pathology slides were used. No consent was obtained from the participant due to retrospective nature of the case and since only intra-oral images and pathology slides were used.

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Georgaki, M., Theofilou, V.I., Pettas, E. et al. Blastoid Mantle Cell Lymphoma of the Palate: Report of a Rare Aggressive Entity and Review of the Literature. Head and Neck Pathol 16, 631–642 (2022). https://doi.org/10.1007/s12105-021-01391-9

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