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The FeNO Normal Value Analysis of Healthy Children Aged 6–15 Years Old in Chengdu

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Abstract

Objective

To investigate the fractional exhaled nitric oxide (FeNO) normal value of healthy children, and provide a reliable theoretical basis for clinical diagnosis.

Methods

481 healthy children aged 6–15-y-old in three primary schools in Chengdu were subjected for FeNO detection. Through the statistical analysis, the upper limit normal value of FeNO among the healthy children was obtained, and the related influencing factors of FeNO value were analyzed.

Results

Among the 481 heathy children, the geometric mean value of FeNO was 14.59 ppb (minimum value was 5 ppb, maximum value was 69 ppb), and the upper limit of normal value was 28 ppb. The age, height, and weight all have significant correlations with FeNO.

Conclusion

The upper limit of FeNO in healthy children aged 6–15-y-old was 28.0 ppb. Inflammation in the airway was suggested when the value of FeNO exceeds 28.0 ppb. Furthermore, the influencing factors such as age, weight, height must be considered.

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Funding

Sichuan Science and Technology Department Popularization and Application Project.

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Authors and Affiliations

  1. Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617, Section 1, Riyue Avenue, Qingyang District, Chengdu City, Sichuan Province, China

    Tao Ai, Ronghua Luo, Lei Zhang, Li Wang, Huiling Liao, Yinghong Fan, Ya** Duan & Yijie Huang

Authors
  1. Tao Ai
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  2. Ronghua Luo
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  3. Lei Zhang
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  4. Li Wang
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  5. Huiling Liao
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  6. Yinghong Fan
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  7. Ya** Duan
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  8. Yijie Huang
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Contributions

YH and LW: Literature search; YF, HL: Data collection; RL: Study design; LZ: Analysis of data; LZ, LW: Manuscript preparation; RL and TA: Review of manuscript. TA will act as guarantor for this paper.

Corresponding author

Correspondence to Tao Ai.

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Cite this article

Ai, T., Luo, R., Zhang, L. et al. The FeNO Normal Value Analysis of Healthy Children Aged 6–15 Years Old in Chengdu. Indian J Pediatr 88, 753–756 (2021). https://doi.org/10.1007/s12098-020-03649-6

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  • DOI: https://doi.org/10.1007/s12098-020-03649-6

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