Abstract
Mannosylerythritol-lipids-B (MEL-B) are microbial-produced glycolipids with skincare properties, notably moisturizing, antimelanogenic, antimicrobial, and antiaging. Thus, there is a potential use of MEL-B in a formulation for treating acne-prone skin. This study investigated the antimicrobial effect of MEL-B against the Gram-positive bacteria Cutibacterium acnes. The broth macro dilution method was used to evaluate the growth of C. acnes (3–4 CFU/mL), in the absence (positive control) or presence of MEL-B (128, 192, 256, and 512 μg/mL). Additionally, the leakage of genetic materials was used to determine the potential drug-induced membrane disruption of glycolipids. The amount of DNA and RNA release was quantified spectrophotometrically at 260 nm. Macro dilution technique and membrane integrity experiments showed that MEL-B does not have antimicrobial activity against C. acnes. Indeed, MEL-B assisted C. acnes growth. Ultimately, MEL-B has been reported as a remarkably active compound for skincare formulations; however, preliminarily, it should be avoided for acneic skin.
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Acknowledgements
This study received financial support from the Brazilian Agencies: the Coordination for the Improvement of Higher Education Personnel (CAPES) (Grant Nos. 88887.310560/2018-00 and 88887.310373/2018-00) and the National Council for Scientific and Technological Development (CNPq).
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All authors contributed to the manuscript’s conception and design. Material preparation and data collection were performed by ALSC and DAL. Data analysis was performed by all authors. The first draft of the manuscript was written by ALSC. All authors commented on previous versions, revised the language, and approved the final manuscript.
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Coelho, A.L.S., Laroque, D.A., Feuser, P.E. et al. Effects of Mannosylerythritol-Lipids-B on Cutibacterium acnes ATCC 6919. Indian J Microbiol 64, 225–228 (2024). https://doi.org/10.1007/s12088-023-01169-3
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DOI: https://doi.org/10.1007/s12088-023-01169-3