Abstract
Background. Diphtheria is an important vaccine preventable disease with varied outcome from mild to death. It was observed that the outcome also gets affected with status of immunization. The outcome is relatively milder in immunized children. Objective. To find out the clinical presentation and outcome of diphtheria cases and its association with the immunization status. Methods. A descriptive analysis of 64 diphtheria cases admitted from January 2019 to May 2020 at SMS hospital, a tertiary care referral hospital in Jaipur. Results. Half of (51.56%, 33/60) patients were in the age group of 6–10 years. The peak load (48.44%) of diphtheria cases was seen in the monsoon season. Around 60% of the patients were fully immunized and around 10% partially immunized, every third case was un-immunized. The most common complication was neurological in 13 cases (20.31%), followed by cardiac complications in 11 cases (17.19%), and respiratory (7.81%). The proportion of complication was much lower (26.3%) in immunized cases as compare to partially immunized and un immunized. The proportion of myocarditis was significantly higher in un immunized cases (40%) than partially immunized (16.7%) and filly immunized group (5.3%). Similarly, Bronchopneumonia was also significantly higher (20%) in unimmunized. Conclusion. Our study depicted that there has been a shift of age above 5 years for diphtheria which suggests the need for the booster dose. Also high chances of complications are seen in unimmunized and partially immunized calling for public awareness regarding complete immunization.
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References
Mateen FJ, Bahl S, Khera A, Sutter RW (2013) Detection of diphtheritic polyneuropathy by acute flaccid paralysis surveillance. India Emerg Infect Dis 19:1368–1373
Murhekar MV, Bitragunta S (2011) Persistence of diphtheria in India. Indian J Community Med 36:164–165
Bisgard KM, Rhodes P, Hardy IR, Litkina IL, Filatov NN, Monisov AA et al (2000) Diphtheria toxoid vaccine effectiveness: a case-control study in Russia. J Infect Dis 181(Suppl 1):S184–S187
Nanthavong N, Black AP, Nouanthong P, Souvannaso C, Vilivong K, Muller CP et al (2015) Diphtheria in Lao PDR: insufficient coverage or ineffective Vaccine? PLoS One 10:00121749
Murakami H, Phuong NM, Thang HV, Chau NV, Giao PN, Tho ND (2010) Endemic diphtheria in Ho Chi Minh City; Viet Nam: a matched case-control study to identify risk factors of incidence. Vaccine 28:8141–8146
Center for Disease Control and Prevention (2015) Corynebacterium diphtheriae. In: Hamborsky J, Kroger A, Wolfe S (eds) Epidemiology & prevention of vaccine- preventable diseases, 13th edn. Public Health Foundation, Washington D.C., pp 107–117
Meera M, Rajarao M (2014) Diphtheria in Andhra Pradesh – a clinical-epidemiological study. Int J Infect Dis 19:74–78
World Health Organization. Diphtheria vaccine: WHO position paper, August 2017-Recommendations. Vaccine. 2018;36(2):199-201
Ujwal MV, Pol RR, Vanaki R, Yelamali BC, Badakali AV (2019) Resurgence of diphtheria in rural north Karnataka: clinical profile and outcome. Int J Med Paediatr Oncol 5(1):17–20
Meshram RM, Patil A (2018) Clinical profile and outcome of diphtheria in central India: a retrospective observational. Study Int J Contemp Pediatr 5(4):1600–1605
Basavaraja GV, Chebbi PG, Joshi S (2016) Resurgence of diphtheria: clinical profile and outcome- a retrospective observational study. Int J of Contemp Pediatr 3(1):60–63
Bandichhode ST, Jatti GM, Anita MS, Nandimath VA (2016) A clinical study of diphtheria cases in a pediatric population in tertiary care hospital in western Maharashtra. Indian J Child Health 3(3):251–255
Suligavi SS, Vishwanath DK, Gokale S, Doddamani SS (2021) Diphtheria: a re-emerging infectious disease. Int J Otorhinolaryngol Head Neck Surg 7:475–480
Maheriya KM, Pathak GH, Chauhan AV, Mehariya MK, Agrawal PC (2014) Clinical and epidemiological profile of diphtheria in tertiary care hospital. Gujarat Med J 89(2):105–108
Arya P, Maharia MS, Kadela RK, Deepchand (2019) A clinical study of complications of diphtheria. Int J Otorhinolaryngol Head Neck Surg 5:1052–5
Jain A, Samdani S, Meena V, Sharma MP (2016) Diphtheria: it is still prevalent. Int J Pediatr Otorhinolaryngol 86:68–71
Siakia L, Nath R, Saikia NJ, Choudhary G, Sarkar M (2010) A diphtheria outbreak in Assam, India. Southeast Asian J Trop Med Public Health 41:647–652
Jayshree M, Shruthi N, Singhi S (2006) Predictors of outcome in patients with diphtheria receiving intensive care. Indian Pediatr 43:155–160
Havaldar PV (1992) Diphtheria in the eighties. Experience in a south Indian district hospital. J Indian Med Assoc 90:155–156
Sharma NC, Banavaliker JN, Ranjan R, Kumar R (2007) Bacteriological and epidemiological characteristics of diphtheria cases in and around Delhi-a retrospective study. Indian J Med Res 126(6):545–552
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No financial funding received. Patients were treated free of cost under ‘MNDY (Mukhyamantri Nishulk Dava Yojana) scheme’ sponsored by Government of Rajasthan.
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“All procedures performed in the presented study involving human participants were in accordance with the ethical standards of the institutional ethical committee of SMS Medical College Jaipur and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”
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Sharma, S., Jammar, S., Kataria, T. et al. An Observational Study on Association of Clinical Outcome of Diphtheria Cases with Immunization Status: A Tertiary Care Hospital, Jaipur. Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 5460–5464 (2022). https://doi.org/10.1007/s12070-021-02769-5
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DOI: https://doi.org/10.1007/s12070-021-02769-5