Abstract
The definition, origin and recreation of life remain elusive. As others have suggested, only once we put life into reductionist physical terms will we be able to solve those questions. To that end, this work proposes the phenomenon of life to be the product of two dissipative mechanisms. From them, one characterises extant biological life and deduces a testable scenario for its origin. The proposed theory of life allows its replication, reinterprets ecological evolution and creates new constraints on the search for life.
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References
Ashkenasy G, Hermans TM, Otto S, Taylor AF (2017) Systems chemistry. Chem Soc Rev 46:2543–2554. https://doi.org/10.1039/C7CS00117G
Baymann F, Schoepp-Cothenet B, Duval S, Guiral M, Brugna M, Baffert C, Russell MJ, Nitschke W (2018) On the natural history of flavin-based electron bifurcation. Front Microbiol. https://doi.org/10.3389/fmicb.2018.01357
Benner SA (2010) Defining life. Astrobiology 10:1021–1030. https://doi.org/10.1089/ast.2010.0524
Benner SA, Hurter D (2002) Phosphates, DNA, and the search for nonterrean life: a second generation model for genetic molecules. Bioorg Chem 30:62–80. https://doi.org/10.1006/bioo.2001.1232
Benner SA, Ricardo A, Carrigan MA (2004) Is there a common chemical model for life in the universe? Curr Opin Chem Biol 8:672–689. https://doi.org/10.1016/j.cbpa.2004.10.003
Benson EE, Kubiak CP, Sathrum AJ, Smieja JM (2009) Electrocatalytic and homogeneous approaches to conversion of CO2 to liquid fuels. Chem Soc Rev 38:89–99. https://doi.org/10.1039/B804323J
Blackmond DG (2009) An examination of the role of autocatalytic cycles in the chemistry of proposed primordial reactions. Angew Chem Int Ed 48:386–390. https://doi.org/10.1002/anie.200804565
Bludau I, Aebersold R (2020) Proteomic and interactomic insights into the molecular basis of cell functional diversity. Nat Rev Mol Cell Biol 21:327–340. https://doi.org/10.1038/s41580-020-0231-2
Branscomb E, Russell MJ (2013) Turnstiles and bifurcators: the disequilibrium converting engines that put metabolism on the road. Biochem Biophys Acta 1827:62–78. https://doi.org/10.1016/j.bbabio.2012.10.003
Buckel W, Thauer RK (2018) Flavin-based electron bifurcation, a new mechanism of biological energy coupling. Chem Rev 118:3862–3886. https://doi.org/10.1021/acs.chemrev.7b00707
Cable ML, Hörst SM, Hodyss R, Beauchamp PM, Smith MA, Willis PA (2012) Titan tholins: simulating Titan organic chemistry in the cassini-huygens era. Chem Rev 112:1882–1909. https://doi.org/10.1021/cr200221x
Chodasewicz K (2014) Evolution, reproduction and definition of life. Theory Biosci 133:39–45. https://doi.org/10.1007/s12064-013-0184-5
Cleland CE, Chyba CF (2002) Defining ‘life.’ Orig Life Evol Biosph 32:387–393. https://doi.org/10.1023/A:1020503324273
Cockell CS, Bush T, Bryce C, Direito S, Fox-Powell M, Harrison JP, Lammer H, Landenmark H, Martin-Torres J, Nicholson N, Noack L, O’Malley-James J, Payler SJ, Rushby A, Samuels T, Schwendner P, Wadsworth J, Zorzano MP (2016) Habitability: a review. Astrobiology 16:89–117. https://doi.org/10.1089/ast.2015.1295
Danchin É, Charmantier A, Champagne FA, Mesoudi A, Pujol B, Blanchet S (2011) Beyond DNA: integrating inclusive inheritance into an extended theory of evolution. Nat Rev Genet 12:475–486. https://doi.org/10.1038/nrg3028
Deamer D (2017) The role of lipid membranes in life’s origin. Life. https://doi.org/10.3390/life7010005
Djokic T, Van Kranendonk MJ, Campbell KA, Walter MR, Ward CR (2017) Earliest signs of life on land preserved in ca. 3.5 Ga hot spring deposits. Nature Commun 8: 15263 https://doi.org/10.1038/ncomms15263
Dodd MS, Papineau D, Grenne T, Slack JF, Rittner M, Pirajno F, O’Neil J, Little CTS (2017) Evidence for early life in earth’s oldest hydrothermal vent precipitates. Nature 543:60–64. https://doi.org/10.1038/nature21377
Epstein IR (2014) Coupled chemical oscillators and emergent system properties. Chem Commun 50:10758–10767. https://doi.org/10.1039/c4cc00290c
Evans DH (2008) One-electron and two-electron transfers in electrochemistry and homogeneous solution reactions. Chem Rev 108:2113–2144. https://doi.org/10.1021/cr068066l
Fuchs G (2011) Alternative pathways of carbon dioxide fixation: Insights into the early evolution of life? Annu Rev Microbiol 65:631–658. https://doi.org/10.1146/annurev-micro-090110-102801
Herrmann G, Jayamani E, Mai G, Buckel W (2008) Energy conservation via electron-transferring flavoprotein in anaerobic bacteria. J Bacteriol 190:784–791. https://doi.org/10.1128/JB.01422-07
Javaux EJ (2019) Challenges in evidencing the earliest traces of life. Nature 572:451–460. https://doi.org/10.1038/s41586-019-1436-4
Joyce GF (2002) The antiquity of RNA-based evolution. Nature 418:214–221. https://doi.org/10.1038/418214a
Kaufmann M (2009) On the free energy that drove primordial anabolism. Int J Mol Sci 10:1853–1871. https://doi.org/10.3390/ijms10041853
Keefe AD, Miller SL (1995) Are polyphosphates or phosphate esters prebiotic reagents? J Mol Evol 41:693–702. https://doi.org/10.1007/BF00173147
Kondepudi D, Prigogine I (2014) Nonequilibrium thermodynamics: the foundations. In: Kondepudi D, Prigogine I (eds) Modern thermodynamics: from heat engines to dissipative structures. Wiley, pp 341–356
Koonin EV, Novozhilov AS (2017) Origin and evolution of the universal genetic code. Annu Rev Genet 51:45–62. https://doi.org/10.1146/annurev-genet-120116-024713
Koshland DE (2002) The seven pillars of life. Science 295:2215–2216. https://doi.org/10.1126/science.1068489
Kostic MM (2020) The second law and entropy misconceptions demystified. Entropy. https://doi.org/10.3390/e22060648
Luecke H, Schobert B, Richter HT, Cartailler JP, Lanyi JK (1999) Structural changes in bacteriorhodopsin during ion transport at 2 angstrom resolution. Science 286:255–260. https://doi.org/10.1126/science.286.5438.255
Luisi PL (1998) About various definitions of life. Orig Life Evol Biosph 28:613–622. https://doi.org/10.1023/a:1006517315105
Merindol R, Walther A (2017) Materials learning from life: concepts for active, adaptive and autonomous molecular systems. Chem Soc Rev 46:5588–5619. https://doi.org/10.1039/c6cs00738d
Miller SL (1953) A production of amino acids under possible primitive earth conditions. Science 117:528–529. https://doi.org/10.1126/science.117.3046.528
Mitchell P (1975) The protonmotive Q cycle: a general formulation. FEBS Lett 59:137–139. https://doi.org/10.1016/0014-5793(75)80359-0
Muchowska KB, Varma SJ, Moran J (2020) Nonenzymatic metabolic reactions and life’s origins. Chem Rev 120:7708–7744. https://doi.org/10.1021/acs.chemrev.0c00191
Müller V, Chowdhury NP, Basen M (2018) Electron bifurcation: a long-hidden energy-coupling mechanism. Annu Rev Microbiol 72:331–353. https://doi.org/10.1146/annurev-micro-090816-093440
Muratsugu S, Sodeyama K, Kitamura F, Tsukada S, Tada M, Tsuneyuki S, Nishihara H (2011) Normal and inverted redox potentials and structural changes tuned by medium effects in [M2Mo(η5-C5Me5)2(S2C6H4)2(CO)2] (M: Co, Rh). Chem Sci 2:1960–1968. https://doi.org/10.1039/c1sc00272d
Nisbet EG, Sleep NH (2001) The habitat and nature of early life. Nature 409:1083–1091. https://doi.org/10.1038/35059210
Nitschke W, Russell MJ (2012) Redox bifurcations: mechanisms and importance to life now, and at its origin: a widespread means of energy conversion in biology unfolds. BioEssays 34:106–109. https://doi.org/10.1002/bies.201100134
Orgel LE (2008) The implausibility of metabolic cycles on the prebiotic earth. PLoS Biol 6:5–13. https://doi.org/10.1371/journal.pbio.0060018
Peters JW, Miller AF, Jones AK, King PW, Adams MWW (2016) Electron bifurcation. Curr Opin Chem Biol 31:146–152. https://doi.org/10.1016/j.cbpa.2016.03.007
Preiner M, Asche S, Becker S, Betts HC, Boniface A, Camprubi E, Chandru K, Erastova V, Garg SG, Khawaja N, Kostyrka G, Machné R, Moggioli G, Muchowska KB, Neukirchen S, Peter B, Pichlhöfer E, Radványi Á, Rossetto D, Salditt A, Schmelling NM, Sousa FL, Tria FDK, Vörös D, Xavier JC (2020) The future of origin of life research: bridging decades-old divisions. Life. https://doi.org/10.3390/life10030020
Ricklefs RE (2008) The economy of nature, 6th edn. W. H. Freeman & Co., New York, NY
Russell MJ, Barge LM, Bhartia R, Bocanegra D, Bracher PJ, Branscomb E, Kidd R, McGlynn S, Meier DH, Nitschke W, Shibuya T, Vance S, White L, Kanik I (2014) The drive to life on wet and Icy Worlds. Astrobiology 14:308–343. https://doi.org/10.1089/ast.2013.1110
Schwieterman EW, Kiang NY, Parenteau MN, Harman CE, Dassarma S, Fisher TM, Arney GN, Hartnett HE, Reinhard CT, Olson SL, Meadows VS, Cockell CS, Walker SI, Grenfell JL, Hegde S, Rugheimer S, Hu R, Lyons TW (2018) Exoplanet biosignatures: a review of remotely detectable signs of life. Astrobiology 18:663–708. https://doi.org/10.1089/ast.2017.1729
Smith E, Morowitz HJ (2004) Universality in intermediary metabolism. Proc Natl Acad Sci USA 101:13168–13173. https://doi.org/10.1073/pnas.0404922101
Sutherland JD (2017) Opinion: Studies on the origin of life - The end of the beginning. Nature Rev Chem. https://doi.org/10.1038/s41570-016-0012
Trifonov EN (2011) Vocabulary of definitions of life suggests a definition. J Biomol Struct Dyn 29:259–266. https://doi.org/10.1080/073911011010524992
Uhrhammer D, Schultz FA (2002) Energetics of concerted two-electron transfer and metal-metal bond cleavage in phosphido-bridged molybdenum and tungsten carbonyl complexes. J Phys Chem A 106:11630–11636. https://doi.org/10.1021/jp021557z
Van Zuilen MA, Lepland A, Arrhenius G (2002) Reassessing the evidence for the earliest traces of life. Nature 418:627–630. https://doi.org/10.1038/nature00934
Varela FG, Maturana HR, Uribe R (1974) Autopoiesis: the organization of living systems, its characterization and a model. BioSystems 5:187–196. https://doi.org/10.1016/0303-2647(74)90031-8
Wächtershäuser G (2006) From volcanic origins of chemoautotrophic life to bacteria, archaea and Eukarya. Philos Trans Royal Soc b: Biol Sci 361:1787–1806. https://doi.org/10.1098/rstb.2006.1904
Walker SI (2017) Origins of life: a problem for physics, a key issues review. Rep Prog Phys 80:092601. https://doi.org/10.1088/1361-6633/aa7804
Weber AL (2007) The sugar model: autocatalytic activity of the triose-ammonia reaction. Orig Life Evol Biosph 37:105–111. https://doi.org/10.1007/s11084-006-9059-9
Weber BH (2010) What is life? Defining life in the context of emergent complexity. Orig Life Evolut Biosph 40:221–229. https://doi.org/10.1007/s11084-010-9203-4
Weiss MC, Sousa FL, Mrnjavac N, Neukirchen S, Roettger M, Nelson-Sathi S, Martin WF (2016) The physiology and habitat of the last universal common ancestor. Nature Microbiol. https://doi.org/10.1038/nmicrobiol.2016.116
Westheimer FH (1987) Why nature chose phosphates. Science 235:1173–1178. https://doi.org/10.1126/science.2434996
Wolos A, Roszak R, Zadlo-Dobrowolska A, Beker W, Mikulak-Klucznik B, Spólnik G, Dygas M, Szymkuc S, Grzybowski BA (2020) Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry. Science. https://doi.org/10.1126/science.aaw1955
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Gonçalves, D. Rethinking life and predicting its origin. Theory Biosci. (2024). https://doi.org/10.1007/s12064-024-00420-9
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DOI: https://doi.org/10.1007/s12064-024-00420-9