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Preoperative Low Creatine Kinase as a Poor Prognostic Factor in Patients with Colorectal Cancer

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Abstract

Purpose

This study aimed to evaluate the clinicopathological and prognostic significance of preoperative serum creatine kinase (CK) levels in colorectal cancer.

Methods

This study analyzed 1169 patients with colorectal cancer at stages 0 (n = 35), I (n = 301), II (n = 456), III (n = 339), and IV (n = 38). The CK cut-off value was 52 U/L to predict recurrence based on receiver operative characteristics curve. Clinicopathological factors were compared between the low (< 52 U/L) and high CK groups (≥ 52 U/L). The multivariate analysis evaluated relapse-free survival (RFS) and overall survival (OS) following CK status.

Results

The female sex, elderly age (≥ 75), deep tumor (pT4), and carcinoembryonic antigen (+) were independently associated with low CK status. The recurrent rate was significantly higher in the low CK group than in the high CK group (19.1% vs. 11.7%, p < 0.001). Elderly age, pT4, pN (+), preoperative carbohydrate antigen (CA) 19-9 (+), and low CK status were independent risk factors for RFS. Elderly age, pT4, pN (+), preoperative CA19-9 (+), and low CK status were independent risk factors for OS.

Conclusion

Preoperative low CK status was associated with deep tumors and was a poor prognostic factor in patients with colorectal cancer.

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Data Availability

No datasets were generated or analysed during the current study.

Abbreviations

CK:

Creatine kinase

CEA:

Carcinoembryonic antigen

CA19-9:

Carbohydrate antigen 19-9

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Acknowledgements

We thank Seiko Otsuka (Toho University) for preparing the ethical documents. Additionally, we would like to thank MARUZEN-YUSHODO Co., Ltd. (https://kw.maruzen.co.jp/kousei-honyaku/) for the English language editing.

Funding

No funding was received for this work.

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Authors and Affiliations

  1. Department of Surgery, Toho University School of Medicine, Tokyo, Japan

    Mitsunori Ushigome, Hideaki Shimada, Tomoaki Kaneko, Yasuyuki Miura, Kimihiko Yoshida, Takayuki Suzuki, Satoru Kagami, Akiharu Kurihara & Kimihiko Funahashi

  2. Department of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan

    Hideaki Shimada

Authors
  1. Mitsunori Ushigome
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Contributions

MU, HS, and K conceived and designed the current study. MU, TK, YM, KY, TS, SK, and AK contributed to the acquisition of the patient’s clinicopathological data. MU and HSH analyzed the patient data. MU and HS drafted the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Hideaki Shimada.

Ethics declarations

Ethics Approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Toho University Omori Medical Center (#M21320 21039 20200 30196 19056 18002).

Consent to Participate

The participants were given the opportunity to decline to be enrolled in the study (opt-out).

Competing Interests

The authors declare no competing interests.

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Ushigome, M., Shimada, H., Kaneko, T. et al. Preoperative Low Creatine Kinase as a Poor Prognostic Factor in Patients with Colorectal Cancer. J Gastrointest Canc (2024). https://doi.org/10.1007/s12029-024-01069-9

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