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Circulating microRNA-1a is a biomarker of Graves’ disease patients with atrial fibrillation

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Abstract

Purpose

It has been increasingly suggested that specific microRNAs expression profiles in the circulation and atrial tissue are associated with the susceptibility to atrial fibrillation. Nonetheless, the role of circulating microRNAs in Graves’ disease patients with atrial fibrillation has not yet been well described. The objective of the study was to identify the role of circulating microRNAs as specific biomarkers for the diagnosis of Graves’ disease with atrial fibrillation.

Methods

The expression profiles of eight serum microRNAs, which are found to be critical in the pathogenesis of atrial fibrillation, were determined in patients with Graves’ disease with or without atrial fibrillation. MicroRNA expression analysis was performed by real-time PCR in normal control subjects (NC; n = 17), patients with Graves’ disease without atrial fibrillation (GD; n = 29), patients with Graves’ disease with atrial fibrillation (GD + AF; n = 14), and euthyroid patients with atrial fibrillation (AF; n = 22).

Results

Three of the eight serum microRNAs,i.e., miR-1a, miR-26a, and miR-133, had significantly different expression profiles among the four groups. Spearman’s correlation analysis showed that the relative expression level of miR-1a was positively correlated with free triiodothyronine (FT3) and free thyroxine (FT4), and negatively related to thyroid stimulating hormone. Spearman’s correlations analysis also revealed that the level of miR-1a was negatively correlated with a critical echocardiographic parameter (left atrial diameter), which was dramatically increased in GD + AF group compared to GD group. Furthermore, the receiver-operating characteristic curve analysis indicated that, among the eight microRNAs, miR-1a had the largest area under the receiver-operating characteristic curves not only for discriminating between individuals with and without Graves’ disease, but also for predicting the presence of atrial fibrillation in patients with Graves’ disease.

Conclusions

Our findings showed that the levels of serum miR-1a were significantly decreased in GD + AF group compared with GD group, suggesting that serum miR-1a might serve as a novel biomarker for diagnosis of atrial fibrillation in patients with Graves’ disease.

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Funding

This study was supported by the National Natural Science Foundation of China (81400834), Young Talents Training Project of Tongji University (2013KJ092), and a grant of People’s Hospital of Shanghai Putuo District (RYK15-08).

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Authors and Affiliations

  1. Department of Endocrinology, People’s Hospital of Shanghai Putuo District, Shanghai, 200060, China

    Fang Wang & Dong-mei Tian

  2. Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    Sheng-jie Zhang, Xuan Yao & Hao Ying

  3. Department of Endocrinology, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai, 200065, China

    Ke-qin Zhang, Dun-min She & Ying Xue

  4. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    Fei-fan Guo & Qi-wei Zhai

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Correspondence to Ying Xue.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of ethic committees of our hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Wang, F., Zhang, Sj., Yao, X. et al. Circulating microRNA-1a is a biomarker of Graves’ disease patients with atrial fibrillation. Endocrine 57, 125–137 (2017). https://doi.org/10.1007/s12020-017-1331-4

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