SpringerLink
Log in

Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis

  • Review
  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Zinc supplementation has therapeutic effects on cardiovascular disease (CVD) risk factors, including dyslipidemia, hyperglycemia, and inflammation as the main contributors to CVD pathogenesis. Since CVD is a major cause of mortality among people with type 2 diabetes mellitus (T2DM), this study aimed to overview the potential effects of zinc supplementation on CVD risk factors in T2DM patients. To determine appropriate randomized clinical trials (RCTs) investigating the effects of zinc supplementation on CVD risk factors, electronic sources including PubMed, Web of Science, and Scopus were systematically searched until January 2023. The heterogeneity of trials was checked using the I2 statistic. According to the heterogeneity tests, random-effects models were estimated, and pooled data were defined as the weighted mean difference (WMD) with a 95% confidence interval (CI). Of the 4004 initial records, 23 studies that met inclusion criteria were analyzed in this meta-analysis. The pooled findings indicated the significant lowering effects of zinc supplementation on triglycerides (TG), total cholesterol (TC), fasting blood glucose (FBG), hemoglobin A1C (HbA1C), and C-reactive protein (CRP), while high-density cholesterol (HDL) concentrations showed an elevation after zinc supplementation. In addition to statistical significance, the effect of zinc supplementation on most of the variables was clinically significant; however, the quality of evidence in the included studies is regarded as low or very low for most variables. Our study demonstrated that zinc supplementation has beneficial effects on glycemic control markers, lipid profile, and CRP levels as a classic marker of inflammation in T2DM. Due to the high degree of heterogeneity between studies and the low rate of quality in them, further well-designed studies are necessitated to strengthen our findings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

Data Availability

Data sharing is applicable.

References

  1. Maret W (2017) Zinc in pancreatic islet biology, insulin sensitivity, and diabetes. Prev Nutr Food Sci 22(1):1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Oguntibeju OO (2019) Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. Int J Physiol Pathophysiol Pharmacol 11(3):45–63

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Herman WH (2017) The global burden of diabetes: an overview. In: Diabetes mellitus in develo** countries and underserved communities, pp 1–5

    Google Scholar 

  4. Cho NH, Shaw J, Karuranga S, Huang Y, da Rocha FJ, Ohlrogge A et al (2018) IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 138:271–281

    Article  CAS  PubMed  Google Scholar 

  5. Shaw JE, Sicree RA, Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87(1):4–14

    Article  CAS  PubMed  Google Scholar 

  6. Garcia C, Feve B, Ferré P, Halimi S, Baizri H, Bordier L et al (2010) Diabetes and inflammation: fundamental aspects and clinical implications. Diabetes Metab 36(5):327–338

    Article  CAS  PubMed  Google Scholar 

  7. Eslampour E, Ebrahimzadeh F, Abbasnezhad A, Khosroshahi MZ, Choghakhori R, Asbaghi O (2019) Association between circulating irisin and c-reactive protein levels: a systematic review and meta-analysis. Endocrinol Metab (Seoul) 34(2):140–149

    Article  CAS  PubMed  Google Scholar 

  8. Yeh ET, Willerson JT (2003) Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation 107(3):370–371

    Article  PubMed  Google Scholar 

  9. Ridker PM (2003) Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107(3):363–369

    Article  PubMed  Google Scholar 

  10. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M et al (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358(24):2560–2572

    Article  CAS  PubMed  Google Scholar 

  11. Banegas JR, López-García E, Graciani A, Guallar-Castillón P, Gutierrez-Fisac JL, Alonso J et al (2007) Relationship between obesity, hypertension and diabetes, and health-related quality of life among the elderly. Eur J Prev Cardiol 14(3):456–462

    Article  Google Scholar 

  12. Matheus AS, Tannus LR, Cobas RA, Palma CC, Negrato CA, Gomes MB (2013) Impact of diabetes on cardiovascular disease: an update. Int J Hypertens 2013:653789

    Article  PubMed  PubMed Central  Google Scholar 

  13. Association AD (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26(suppl 1):s5–s20

    Google Scholar 

  14. Al Ghatrif M, Kuo Y-F, Al Snih S, Raji MA, Ray LA, Markides KS (2011) Trends in hypertension prevalence, awareness, treatment and control in older Mexican Americans, 1993–2005. Ann Epidemiol 21(1):15–25

    Article  Google Scholar 

  15. Evert AB, Boucher JL, Cypress M, Dunbar SA, Franz MJ, Mayer-Davis EJ et al (2013) Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care 36(11):3821–3842

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Kim Y, Oh YK, Lee J, Kim E (2022) Could nutrient supplements provide additional glycemic control in diabetes management? A systematic review and meta-analysis of randomized controlled trials of as an add-on nutritional supplementation therapy. Arch Pharm Res 45(3):185–204

  17. Chabosseau P, Rutter GA (2016) Zinc and diabetes. Arch Biochem Biophys 611:79–85

    Article  CAS  PubMed  Google Scholar 

  18. Hosseini R, Ferns GA, Sahebkar A, Mirshekar MA, Jalali M (2021) Zinc supplementation is associated with a reduction in serum markers of inflammation and oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. Cytokine 138:155396

    Article  CAS  PubMed  Google Scholar 

  19. Rohm TV, Meier DT, Olefsky JM, Donath MY (2022) Inflammation in obesity, diabetes, and related disorders. Immunity 55(1):31–55

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Kinlaw WB, Levine AS, Morley JE, Silvis SE, McClain CJ (1983) Abnormal zinc metabolism in type II diabetes mellitus. Am J Med 75(2):273–277

    Article  CAS  PubMed  Google Scholar 

  21. Tallman DL, Taylor CG (2003) Effects of dietary fat and zinc on adiposity, serum leptin and adipose fatty acid composition in C57BL/6J mice. J Nutr Biochem 14(1):17–23

    Article  CAS  PubMed  Google Scholar 

  22. Marreiro DDN, Fisberg M, Cozzolino SMF (2002) Zinc nutritional status in obese children and adolescents. Biol Trace Elem Res 86(2):107–122

    Article  PubMed  Google Scholar 

  23. Cruz KJC, de Oliveira ARS, Morais JBS, Severo JS, Mendes PMV, de Sousa Melo SR et al (2018) Zinc and insulin resistance: biochemical and molecular aspects. Biol Trace Elem Res 186(2):407–412

    Article  CAS  PubMed  Google Scholar 

  24. Bandeira VDS, Pires LV, Hashimoto LL, Alencar LL, Almondes KGS, Lottenberg SA et al (2017) Association of reduced zinc status with poor glycemic control in individuals with type 2 diabetes mellitus. J Trace Elem Med Biol 44:132–136

    Article  CAS  PubMed  Google Scholar 

  25. Jansen J, Rosenkranz E, Overbeck S, Warmuth S, Mocchegiani E, Giacconi R et al (2012) Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc. J Nutr Biochem 23(11):1458–1466

    Article  CAS  PubMed  Google Scholar 

  26. Jung S, Kim MK, Choi BY (2015) The relationship between zinc status and inflammatory marker levels in rural Korean adults aged 40 and older. PLoS One 10(6):e0130016

    Article  PubMed  PubMed Central  Google Scholar 

  27. Payahoo L, Ostadrahimi A, Mobasseri M, Bishak YK, Farrin N, Jafarabadi MA et al (2013) Effects of zinc supplementation on the anthropometric measurements, lipid profiles and fasting blood glucose in the healthy obese adults. Adv Pharm Bull 3(1):161

    PubMed  PubMed Central  Google Scholar 

  28. Kim J (2013) Dietary zinc intake is inversely associated with systolic blood pressure in young obese women. Nutr Res Pract 7(5):380–384

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Kim J, Ahn J (2014) Effect of zinc supplementation on inflammatory markers and adipokines in young obese women. Biol Trace Elem Res 157(2):101–106

    Article  PubMed  Google Scholar 

  30. Khorsandi H, Nikpayam O, Yousefi R, Parandoosh M, Hosseinzadeh N, Saidpour A et al (2019) Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial. Diabetol Metab Syndr 11:101

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Al-Maroof RA, Al-Sharbatti SS (2006) Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J 27(3):344

    PubMed  Google Scholar 

  32. Afkhami-Ardekani M, Karimi M, Mohammadi SM, Nourani F (2008) Effect of zinc sulfate supplementation on lipid and glucose in type 2 diabetic patients. Pak J Nutr 7(4):550–553

    Article  CAS  Google Scholar 

  33. Partida-Hernández G, Arreola F, Fenton B, Cabeza M, Román-Ramos R, Revilla-Monsalve M (2006) Effect of zinc replacement on lipids and lipoproteins in type 2-diabetic patients. Biomed Pharmacother 60(4):161–168

    Article  PubMed  Google Scholar 

  34. Perez A, Rojas P, Carrasco F, Basfi-Fer K, Perez-Bravo F, Codoceo J et al (2018) Association between zinc nutritional status and glycemic control in individuals with well-controlled type-2 diabetes. J Trace Elem Med Biol 50:560–565

    Article  CAS  PubMed  Google Scholar 

  35. Khan MI, Siddique KU, Ashfaq F, Ali W, Reddy HD, Mishra A (2013) Effect of high-dose zinc supplementation with oral hypoglycemic agents on glycemic control and inflammation in type-2 diabetic nephropathy patients. J Nat Sci Biol Med 4(2):336

    Article  PubMed  PubMed Central  Google Scholar 

  36. Knez M, Glibetic M (2021) Zinc as a biomarker of cardiovascular health. Front Nutr 8:686078

    Article  PubMed  PubMed Central  Google Scholar 

  37. Capdor J, Foster M, Petocz P, Samman S (2013) Zinc and glycemic control: a meta-analysis of randomised placebo controlled supplementation trials in humans. J Trace Elem Med Biol 27(2):137–142

    Article  CAS  PubMed  Google Scholar 

  38. Asbaghi O, Sadeghian M, Fouladvand F, Panahande B, Nasiri M, Khodadost M et al (2020) Effects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 30(8):1260–1271

    Article  CAS  PubMed  Google Scholar 

  39. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264–269 w64

    Article  PubMed  Google Scholar 

  40. Higgins J, Green S (2010) Cochrane handbook for systematic reviews of interventions, version 5.0. 2 [updated Sept 2009], The Cochrane Collaboration, 2009

  41. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188

    Article  CAS  PubMed  Google Scholar 

  42. Borenstein M, Hedges LV, Higgins JP, Rothstein HR (2021) Introduction to meta-analysis. John Wiley & Sons

    Book  Google Scholar 

  43. Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5:13

    Article  PubMed  PubMed Central  Google Scholar 

  44. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. Bmj 327(7414):557–560

    Article  PubMed  PubMed Central  Google Scholar 

  45. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558

    Article  PubMed  Google Scholar 

  46. Tobias A (1999) Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 47:15–17

    Google Scholar 

  47. Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed) 315(7109):629–634

    Article  CAS  PubMed  Google Scholar 

  48. Oh HM, Yoon JS (2008) Glycemic control of type 2 diabetic patients after short-term zinc supplementation. Nutr Res Pract 2(4):283–288

    Article  PubMed  PubMed Central  Google Scholar 

  49. Attia JR, Holliday E, Weaver N, Peel R, Fleming KC, Hure A et al (2022) The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial. Acta Diabetol 59(7):965–975

  50. Foster M, Petocz P, Caterson ID, Samman S (2013) Effects of zinc and α-linolenic acid supplementation on glycemia and lipidemia in women with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial

    Google Scholar 

  51. Chu A, Foster M, Hancock D, Bell-Anderson K, Petocz P, Samman S (2015) TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus. Genes Nutr 10(1):1–10

    Article  Google Scholar 

  52. Ranasinghe P, Wathurapatha WS, Galappatthy P, Katulanda P, Jayawardena R, Constantine GR (2018) Zinc supplementation in prediabetes: a randomized double-blind placebo-controlled clinical trial. J Diabetes 10(5):386–397

    Article  CAS  PubMed  Google Scholar 

  53. Gunasekara P, Hettiarachchi M, Liyanage C, Lekamwasam S (2011) Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes. Diabetes Metab Syndr Obes: Targets Ther 53–60

  54. Seet RC, Lee C-YJ, Lim EC, Quek AM, Huang H, Huang SH et al (2011) Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels. Atherosclerosis 219(1):231–239

    Article  CAS  PubMed  Google Scholar 

  55. El-Ashmony SMA, Morsi HK, Abdelhafez AM (2012) Effect of zinc supplementation on glycemic control, lipid profile, and renal functions in patients with type II diabetes: a single blinded, randomized, placebo-controlled, trial. J Biol Agric Health 2(6):33

    Google Scholar 

  56. Soheylikhah S, Dehestani MR, Mohammadi SM, Afkhami AM, Eghbali SA, Dehghan F (2012) The effect of zinc supplementation on serum adiponectin concentration and insulin resistance in first degree relatives of diabetic patients

  57. Foster M, Chu A, Petocz P, Samman S (2014) Zinc transporter gene expression and glycemic control in post-menopausal women with type 2 diabetes mellitus. J Trace Elem Med Biol 28(4):448–452

    Article  CAS  PubMed  Google Scholar 

  58. Islam MR, Attia J, Ali L, McEvoy M, Selim S, Sibbritt D et al (2016) Zinc supplementation for improving glucose handling in pre-diabetes: a double blind randomized placebo controlled pilot study. Diabetes Res Clin Pract 115:39–46

    Article  CAS  PubMed  Google Scholar 

  59. Momen-Heravi M, Barahimi E, Razzaghi R, Bahmani F, Gilasi HR, Asemi Z (2017) The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Wound Repair Regen 25(3):512–520

    Article  PubMed  Google Scholar 

  60. Naghizadeh S, Kheirouri S, Ojaghi H, Kaffash AJ (2018) Zinc supplementation attenuate diabetic indices in patients with diabetic retinopathy. Prog Nutr 20(2-S):263–269

    CAS  Google Scholar 

  61. Asghari S, Hosseinzadeh-Attar MJ, Alipoor E, Sehat M, Mohajeri-Tehrani MR (2019) Effects of zinc supplementation on serum adiponectin concentration and glycemic control in patients with type 2 diabetes. J Trace Elem Med Biol 55:20–25

    Article  CAS  PubMed  Google Scholar 

  62. Karandish M, Mozaffari-khosravi H, Mohammadi SM, Cheraghian B, Azhdari M (2021) The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: a phase 2 randomized, placebo-controlled trial with a multi-arm, parallel-group design. Phytother Res 35(8):4377–4387

    Article  CAS  PubMed  Google Scholar 

  63. Said E, Mousa S, Fawzi M, Sabry NA, Farid S (2021) Combined effect of high-dose vitamin A, vitamin E supplementation, and zinc on adult patients with diabetes: a randomized trial. J Adv Res 28:27–33

    Article  CAS  PubMed  Google Scholar 

  64. Hosseini R, Karajibani M, Montazerifar F, Shahraki E, Babakhani K, Mohammad Mokhtari A et al (2022) The impact of zinc supplementation on galectin-3 and metabolic markers in diabetic patients on hemodialysis: a randomized, double-blind, placebo-controlled trial. J Diabetes Metab Disord 21(1):743–750

  65. Parham M, Amini M, Aminorroaya A, Heidarian E (2008) Effect of zinc supplementation on microalbuminuria in patients with type 2 diabetes: a double blind, randomized, placebo-controlled, cross-over trial. Rev Diabet Stud 5(2):102

    Article  PubMed  PubMed Central  Google Scholar 

  66. Nazem MR, Asadi M, Jabbari N, Allameh A (2019) Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overweight type 2 diabetes patients: a randomized, double-blind, controlled trial. Clin Biochem 69:15–20

    Article  CAS  PubMed  Google Scholar 

  67. Leon BM, Maddox TM (2015) Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes 6(13):1246–1258

    Article  PubMed  PubMed Central  Google Scholar 

  68. Ghanavati M, Rahmani J, Clark CCT, Hosseinabadi SM, Rahimlou M (2020) Pistachios and cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Med 52:102513

    Article  PubMed  Google Scholar 

  69. Ghanavati M, Hosseinabadi SM, Parsa SA, Safi M, Emamat H, Nasrollahzadeh J (2021) Effect of a nut-enriched low-calorie diet on body weight and selected markers of inflammation in overweight and obese stable coronary artery disease patients: a randomized controlled study. Eur J Clin Nutr 75(7):1099–1108

    Article  CAS  PubMed  Google Scholar 

  70. Zamani M, Rezaei Kelishadi M, Ashtary-Larky D, Ghanavati M, Asaghi O (2023) The effects of green tea supplementation on cardiovascular risk factors: a systematic review and meta-analysis. Front Nutr 9:3245

    Google Scholar 

  71. Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH et al (2014) 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63(25 Pt B):2889–2934

    Article  PubMed  Google Scholar 

  72. Knez M, Pantovic A, Zekovic M, Pavlovic Z, Glibetic M, Zec M (2019) Is there a link between zinc intake and status with plasma fatty acid profile and desaturase activities in dyslipidemic subjects? Nutrients 12(1):93

  73. Gomez NN, Ojeda MS, Gimenez MS (2002) Lung lipid composition in zinc-deficient rats. Lipids 37(3):291–296

    Article  CAS  PubMed  Google Scholar 

  74. Tom Dieck H, Döring F, Fuchs D, Roth HP, Daniel H (2005) Transcriptome and proteome analysis identifies the pathways that increase hepatic lipid accumulation in zinc-deficient rats. J Nutr 135(2):199–205

    Article  CAS  PubMed  Google Scholar 

  75. Sun W, Yang J, Wang W, Hou J, Cheng Y, Fu Y et al (2018) The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes. J Trace Elem Med Biol 46:117–127

    Article  CAS  PubMed  Google Scholar 

  76. Banaszak M, Górna I, Przysławski J (2021) Zinc and the innovative zinc-α2-glycoprotein adipokine play an important role in lipid metabolism: a critical review. Nutrients 13(6):2023

  77. Mocchegiani E, Giacconi R, Malavolta M (2008) Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes. Trends Mol Med 14(10):419–428

    Article  CAS  PubMed  Google Scholar 

  78. Farooq DM, Alamri AF, Alwhahabi BK, Metwally AM, Kareem KA (2020) The status of zinc in type 2 diabetic patients and its association with glycemic control. J Fam Community Med 27(1):29–36

    Article  Google Scholar 

  79. Joseph JJ, Deedwania P, Acharya T, Aguilar D, Bhatt DL, Chyun DA et al (2022) Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association. Circulation 145(9):e722–ee59

    Article  PubMed  Google Scholar 

  80. Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P (2012) Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr 4(1):13

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Fernández-Cao JC, Warthon-Medina M, Moran VH, Arija V, Doepking C, Serra-Majem L et al (2019) Zinc intake and status and risk of type 2 diabetes mellitus: a systematic review and meta-analysis. Nutrients 11(5):1027

  82. Chukwuma CI, Mashele SS, Eze KC, Matowane GR, Islam SM, Bonnet SL et al (2020) A comprehensive review on zinc(II) complexes as anti-diabetic agents: the advances, scientific gaps and prospects. Pharmacol Res 155:104744

    Article  CAS  PubMed  Google Scholar 

  83. Barman S, Srinivasan K (2016) Zinc supplementation alleviates hyperglycemia and associated metabolic abnormalities in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol 94(12):1356–1365

    Article  CAS  PubMed  Google Scholar 

  84. Gunasekara P, Hettiarachchi M, Liyanage C, Lekamwasam S (2011) Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes. Diabetes Metab Syndr Obes 4:53–60

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Cruz KJC, Morais JBS, de Oliveira ARS, Severo JS, DDN M (2017) The effect of zinc supplementation on insulin resistance in obese subjects: a systematic review. Biol Trace Elem Res 176(2):239–243

    Article  CAS  PubMed  Google Scholar 

  86. Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S et al (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol 14(1):50–59

    Article  PubMed  PubMed Central  Google Scholar 

  87. Ceylan MN, Akdas S, Yazihan N (2021) The effects of zinc supplementation on c-reactive protein and inflammatory cytokines: a meta-analysis and systematical review. J Interf Cytokine Res 41(3):81–101

    Article  CAS  Google Scholar 

  88. Gammoh NZ, Rink L (2017) Zinc in infection and inflammation. Nutrients 9(6)

  89. Mohammadi H, Talebi S, Ghavami A, Rafiei M, Sharifi S, Faghihimani Z et al (2021) Effects of zinc supplementation on inflammatory biomarkers and oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. J Trace Elem Med Biol 68:126857

  90. Jafari A, Noormohammadi Z, Askari M, Daneshzad E (2022) Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Food Sci Nutr 62(11):3023–3041

  91. Faghfouri AH, Baradaran B, Khabbazi A, Bishak YK, Zarezadeh M, Tavakoli-Rouzbehani OM et al (2021) Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials 1-10

  92. Ghafourian M, Ashtary-Larky D, Chinipardaz R, Eskandary N, Mehavaran M (2016) Inflammatory biomarkers’ response to two different intensities of a single bout exercise among soccer players. Iran Red Crescent Med J 18(2)

  93. Ashtary-Larky D, Rezaei Kelishadi M, Bagheri R, Moosavian SP, Wong A, Davoodi SH et al (2021) The effects of nano-curcumin supplementation on risk factors for cardiovascular disease: a GRADE-assessed systematic review and meta-analysis of clinical trials. Antioxidants 10(7):1015

  94. Wang Y, Jia X-F, Zhang B, Wang Z-H, Zhang J-G, Huang F-F et al (2018) Dietary zinc intake and its association with metabolic syndrome indicators among Chinese adults: an analysis of the China Nutritional Transition Cohort Survey 2015. Nutrients 10(5):572

  95. Kunutsor SK, Laukkanen JA (2016) Serum zinc concentrations and incident hypertension: new findings from a population-based cohort study. J Hypertens 34(6):1055–1061

    Article  CAS  PubMed  Google Scholar 

  96. He P, Li H, Liu M, Zhang Z, Zhang Y, Zhou C et al (2022) J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China 1-9

  97. Mousavi SM, Mofrad MD, do Nascimento IJ, Milajerdi A, Mokhtari T, Esmaillzadeh A (2020) The effect of zinc supplementation on blood pressure: a systematic review and dose–response meta-analysis of randomized-controlled trials. Eur J Nutr 59(5):1815–1827

    Article  CAS  PubMed  Google Scholar 

  98. Khazdouz M, Djalalinia S, Sarrafi Zadeh S, Hasani M, Shidfar F, Ataie-Jafari A et al (2020) Effects of zinc supplementation on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials. 195(2):373–398

  99. Chait A, den Hartigh LJ (2020) Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med 7:22

  100. Asbaghi O, Naeini F, Ashtary-Larky D, Kaviani M, Kelishadi MR, Eslampour E et al (2021) Effects of chromium supplementation on blood pressure, body mass index, liver function enzymes and malondialdehyde in patients with type 2 diabetes: a systematic review and dose-response meta-analysis of randomized controlled trials. Complement Ther Med 60:102755

  101. Ashtary-Larky D, Bagheri R, Asbaghi O, Tinsley GM, Kooti W, Abbasnezhad A et al (2021) Effects of resistance training combined with a ketogenic diet on body composition: a systematic review and meta-analysis. Crit Rev Food Sci Nutr 62(21):5717–5732

  102. Abdollahi S, Toupchian O, Jayedi A, Meyre D, Tam V, Soltani S (2020) Zinc supplementation and body weight: a systematic review and dose–response meta-analysis of randomized controlled trials. Adv Nutr 11(2):398–411

Download references

Author information

Authors and Affiliations

  1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Matin Nazari

  2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Mahlagha Nikbaf-Shandiz

  3. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fereshteh Pashayee-Khamene

  4. Department of Exercise Physiology, University of Isfahan, Isfahan, Iran

    Reza Bagheri

  5. Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

    Kian Goudarzi, Sina Dolatshahi & Hossein Salehi Omran

  6. Sport Management Department, Human Science Faculty, South Tehran Branch, Islamic Azad University, Tehran, Iran

    Navid Vahid Hosseinnia

  7. Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran

    Niusha Amirani

  8. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Damoon Ashtary-larky

  9. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Omid Asbaghi

  10. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Omid Asbaghi

  11. National Nutrition and Food Technology Research Institute (Faculty of Nutrition Sciences and Food Technology), Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Matin Ghanavati

Authors
  1. Matin Nazari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mahlagha Nikbaf-Shandiz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fereshteh Pashayee-Khamene
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Reza Bagheri
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kian Goudarzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Navid Vahid Hosseinnia
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sina Dolatshahi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hossein Salehi Omran
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Niusha Amirani
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Damoon Ashtary-larky
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Omid Asbaghi
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Matin Ghanavati
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

O.A. and M.G. conceived and designed the research. M.N. conducted experiments. M.N.-S., K.G., and M.N. contributed to new reagents or analytical tools. M.N.-S., H.S.-O., and N.A. analyzed the data. D.A.-L., M.G., F.P.-K., and R.B. drafted the manuscript. R.B. and S.D. revised the manuscript. All authors have read and agreed to the published version of the manuscript.

Corresponding authors

Correspondence to Omid Asbaghi or Matin Ghanavati.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nazari, M., Nikbaf-Shandiz, M., Pashayee-Khamene, F. et al. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. Biol Trace Elem Res 202, 2966–2990 (2024). https://doi.org/10.1007/s12011-023-03895-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-023-03895-7

Keywords

Search

Navigation