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Dietary Serine and Sulfate-Containing Amino Acids Related to the Nutritional Status of Selenium in Lactating Chinese Women

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Abstract

Previous studies suggested that serine can promote the synthesis of selenoproteins and the interaction, transformation, and replacement of serine, cysteine, and selenocysteine have been observed in the human body. This study was designed to clarify whether the dietary intakes of serine and sulfate-containing amino acids (SAAs) could directly affect the selenium (Se) nutritional status or the level of milk Se in lactating women. Breast milk and plasma samples were collected from a total of 264 lactating Chinese women when they revisited their local hospital at the 42nd day postpartum to detect the concentration of Se with ICP-MS and the content of selenoprotein P (SEPP1) and the activity of glutathione peroxidase 3 (GPX3) in the plasma by ELISA. The daily Se intake by each subject was calculated based on her own plasma Se concentration. The 24-h dietary record data for 3 consecutive days were collected to calculate their dietary intakes of protein together with each amino acid daily based on the China Food Composition Tables (CFCT). Ordinal polytomous logistic regression was applied to examine the determinants of BMI values for lactating women. For all subjects, the concentration of plasma SEPP1 and milk Se of participants with insufficient Se intake were significantly associated with the dietary intake of serine and 2 SAAs (methionine and cystine), respectively (P < 0.05). No significant correlation was found between each amino acid related to the synthesis of endogenous serine and every biomarker of the Se nutrition status in subjects with an insufficient dietary protein intake (P > 0.05). The ordinal logistic regression analysis showed that dietary protein intake (ordinal OR 1.012, 95% CI = 0.004–0.020, P = 0.002) and plasma SEPP1 (ordinal OR 0.988, 95% CI = − 0.023 to − 0.001, P = 0.036) affected the BMI value together in these lactating women. In conclusion, dietary serine and SAAs were found to directly affect the nutritional status, and both high protein intake and low plasma SEPP1 might be the health risks in these lactating Chinese women.

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Acknowledgments

This work was financially supported by the Chinese Nutrition Society Nutrition Scientific Research Funds − Yili Nutrition and Health Research Fund (No. 2013-013) and the National Natural Science Foundation of China under the Grant No. 81973048, 81741032, and 81372989. F.H., H.Y.W., and Z.W.H. designed research; F.H., L.P.L, Y.J.C., J.Z., and S.J.W. conducted research; F.H., X.H.P., L.C.S., Q.W., Y.Q.L., and S.Z. analyzed data; F.H. and Z.W.H. wrote the paper; Z.W.H. had primary responsibility for final content. All of the authors read and approved the final manuscript.

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Authors and Affiliations

  1. Department of Nutrition and Metabolism, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, ** Liu

  2. Maternal and Child Care Hospital of **cheng district, Bei**g, 100054, China

    Yingjuan Chai

  3. Center for Disease Control and Prevention of Enshi Autonomous Prefecture, Enshi, 445000, Hubei, China

    Jie Zhang

  4. Center for Disease Control and Prevention of Yi Autonomous Prefecture of Liangshan, Liangshan, 615000, Sichuan, China

    Shi** Wang

  5. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Jianghan District, Wuhan, 430022, Hubei, China

    Hongying Wu

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  1. Feng Han
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Han, F., Pang, X., Wang, Q. et al. Dietary Serine and Sulfate-Containing Amino Acids Related to the Nutritional Status of Selenium in Lactating Chinese Women. Biol Trace Elem Res 199, 829–841 (2021). https://doi.org/10.1007/s12011-020-02204-w

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