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Development of Green-Synthesized Carbon-Based Nanoparticle for Prevention of Surface Wound Biofilm

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Abstract

The development of microbial biofilm occurs with the adherence of the microbial cells on biotic and abiotic surfaces with the help of pili and with extracellular polymeric substances. The surfaces on which biofilm formation take place can be inert, abiotic, or biotic. The sessile microbial cells behave differently from their planktonic counterpart. The biofilm developed by Alcaligenes faecalis is responsible for the development of skin and soft-tissue infection. It was observed that green-synthesized carbon nanoparticles (NPs) from Ocimum sanctum showed a prolonged stability and activity. It showed a marked reduction in the viability of sessile microbial species with least revival in comparison to the plant extract and amoxicillin. It was observed that carbon NP was able to maximally reduce the quorum sensing (QS) activity of A. faecalis. Thus, the use of green-synthesized NPs would be an alternative in the treatment of the biofilm-associated chronic wound infections.

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Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

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Authors and Affiliations

  1. Department of Burn Plastic Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China

    Miaolin Yang & Zhi Li

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  2. Zhi Li
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Yang, M., Li, Z. Development of Green-Synthesized Carbon-Based Nanoparticle for Prevention of Surface Wound Biofilm. Appl Biochem Biotechnol (2023). https://doi.org/10.1007/s12010-023-04695-4

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