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Microvascular Function in Aging Among Women Living with HIV

  • Behavioral-Bio-Medical Interface (JL Brown and RJ DiClemente, Section Editors)
  • Published:
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Abstract

Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (HAND). Microcirculatory changes and endothelial dysfunction occur early both in HIV-infected and in aging patients, in whom they usually precede cardiovascular and neurocognitive impairments. Also, mild cognitive involvement has been reported in women during the menopausal transition. Disruption of the blood-brain barrier, as well as microvascular and cerebral blood flow changes, has been reported in HIV patients with HAND, including postmenopausal women. However, most studies addressing this issue included women aged less than 50 years. Whether HIV-infected women growing older with CART would be subsequently exposed to an increased progression of cognitive impairment overtime remains unknown.

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Authors and Affiliations

  1. AP-HP, Cardiology, Hôpital René Muret, Hôpitaux universitaires de Paris Seine Saint-Denis, Avenue du docteur Schaeffner, F-93270, Sevran, France

    Jean-Jacques Monsuez

  2. AP-HP, Neurology, Hôpital Avicenne, Hôpitaux universitaires de Paris Seine Saint-Denis, Bobigny, France

    Catherine Belin

  3. AP-HP, Infectious diseases, Hôpital Avicenne, Hôpitaux universitaires de Paris Seine Saint-Denis, Bobigny, France

    Olivier Bouchaud

Authors
  1. Jean-Jacques Monsuez
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  2. Catherine Belin
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Correspondence to Jean-Jacques Monsuez.

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Conflict of Interest

Olivier Bouchaud reports grants from GSK, MSD, Gilead, and ANRS; personal fees from BMS, MSD; non-financial support from Gilead and MSD.

Jean-Jacques Monsuez and Catherine Belin declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Behavioral-Bio-Medical Interface

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Monsuez, JJ., Belin, C. & Bouchaud, O. Microvascular Function in Aging Among Women Living with HIV. Curr HIV/AIDS Rep 13, 392–398 (2016). https://doi.org/10.1007/s11904-016-0339-3

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