Abstract
Purpose of Review
Overlap** hemodynamics in constrictive pericarditis (CP) and restrictive cardiomyopathy (RCM) often pose difficulties in establishing accurate diagnosis. Echocardiography is the first-line imaging modality used for this purpose, but no single echocardiographic parameter is sufficiently robust for distinguishing between the two conditions. The newer developments may improve the diagnostic accuracy of echocardiography in this setting.
Recent Findings
Recent studies have validated multiparametric algorithms, based on conventional echocardiographic parameters, which enable high sensitivity and specificity for distinguishing between CP and RCM. In addition, myocardial deformation analysis using speckle-tracking echocardiography has revealed distinct pattern of abnormalities in the two conditions. CP is characterized by impaired left ventricular apical rotation with relatively preserved longitudinal strain, esp. of ventricular and atrial septum. In contrast, RCM results in global and marked impairment of left ventricular longitudinal strain with initially preserved circumferential mechanics.
Summary
Combining multiple echocardiographic parameters into step-wise algorithms and incorporation of myocardial deformation analysis help improve the diagnostic accuracy of echocardiography for distinguishing between CP and RCM. The use of machine-learning may allow easy integration of a wide range of echocardiographic and clinical parameters to permit accurate, automated diagnosis, with less dependence on the user expertise.
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References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Hatle LK, Appleton CP, Popp RL. Differentiation of constrictive pericarditis and restrictive cardiomyopathy by Doppler echocardiography. Circulation. 1989;79:357–70.
Geske JB, Anavekar NS, Nishimura RA, Oh JK, Gersh BJ. Differentiation of constriction and restriction: complex cardiovascular hemodynamics. J Am Coll Cardiol. 2016;68:2329–47.
Klein AL, Abbara S, Agler DA, et al. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease: endorsed by the Society for Cardiovascular Magnetic Resonance and Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr. 2013;26(965–1012): e15.
Goldstein JA, Kern MJ. Hemodynamics of constrictive pericarditis and restrictive cardiomyopathy. Catheter Cardiovasc Interv. 2020;95:1240–8.
Yamada H, Tabata T, Jaffer SJ, et al. Clinical features of mixed physiology of constriction and restriction: echocardiographic characteristics and clinical outcome. Eur J Echocardiogr. 2007;8:185–94.
• Ardhanari S, Yarlagadda B, Parikh V, et al. Systematic review of non-invasive cardiovascular imaging in the diagnosis of constrictive pericarditis. Indian Heart J. 2017;69:57–67. A systematic review summarizing important imaging findings in constrictive pericarditis.
Oh JK, Hatle LK, Seward JB, et al. Diagnostic role of Doppler echocardiography in constrictive pericarditis. J Am Coll Cardiol. 1994;23:154–62.
Welch TD, Ling LH, Espinosa RE, et al. Echocardiographic diagnosis of constrictive pericarditis: Mayo Clinic criteria. Circ Cardiovasc Imaging. 2014;7:526–34.
Ling LH, Oh JK, Tei C, et al. Pericardial thickness measured with transesophageal echocardiography: feasibility and potential clinical usefulness. J Am Coll Cardiol. 1997;29:1317–23.
Talreja DR, Edwards WD, Danielson GK, et al. Constrictive pericarditis in 26 patients with histologically normal pericardial thickness. Circulation. 2003;108:1852–7.
Garcia MJ. Constrictive pericarditis versus restrictive cardiomyopathy? J Am Coll Cardiol. 2016;67:2061–76.
•• Qamruddin S, Alkharabsheh SK, Sato K, et al. Differentiating constriction from restriction (from the Mayo Clinic Echocardiographic Criteria). Am J Cardiol. 2019;124:932–8. A recent study that reevaluated the diagnostic accuracy of the Mayo Clinic criteria for differentiating constriction from restriction.
Sengupta PP, Mohan JC, Mehta V, Arora R, Khandheria BK, Pandian NG. Doppler tissue imaging improves assessment of abnormal interventricular septal and posterior wall motion in constrictive pericarditis. J Am Soc Echocardiogr. 2005;18:226–30.
Dal-Bianco JP, Sengupta PP, Mookadam F, Chandrasekaran K, Tajik AJ, Khandheria BK. Role of echocardiography in the diagnosis of constrictive pericarditis. J Am Soc Echocardiogr. 2009;22:24–33; quiz 103–4.
Rajagopalan N, Garcia MJ, Rodriguez L, et al. Comparison of new Doppler echocardiographic methods to differentiate constrictive pericardial heart disease and restrictive cardiomyopathy. Am J Cardiol. 2001;87:86–94.
Oh JK, Tajik AJ, Appleton CP, Hatle LK, Nishimura RA, Seward JB. Preload reduction to unmask the characteristic Doppler features of constrictive pericarditis. A new observation Circulation. 1997;95:796–9.
Ha JW, Oh JK, Ommen SR, Ling LH, Tajik AJ. Diagnostic value of mitral annular velocity for constrictive pericarditis in the absence of respiratory variation in mitral inflow velocity. J Am Soc Echocardiogr. 2002;15:1468–71.
Sun JP, Abdalla IA, Yang XS, et al. Respiratory variation of mitral and pulmonary venous Doppler flow velocities in constrictive pericarditis before and after pericardiectomy. J Am Soc Echocardiogr. 2001;14:1119–26.
Sengupta PP, Krishnamoorthy VK, Abhayaratna WP, et al. Comparison of usefulness of tissue Doppler imaging versus brain natriuretic peptide for differentiation of constrictive pericardial disease from restrictive cardiomyopathy. Am J Cardiol. 2008;102:357–62.
Sengupta PP, Mohan JC, Mehta V, Arora R, Pandian NG, Khandheria BK. Accuracy and pitfalls of early diastolic motion of the mitral annulus for diagnosing constrictive pericarditis by tissue Doppler imaging. Am J Cardiol. 2004;93:886–90.
Butz T, Piper C, Langer C, et al. Diagnostic superiority of a combined assessment of the systolic and early diastolic mitral annular velocities by tissue Doppler imaging for the differentiation of restrictive cardiomyopathy from constrictive pericarditis. Clin Res Cardiol. 2010;99:207–15.
Ha JW, Ommen SR, Tajik AJ, et al. Differentiation of constrictive pericarditis from restrictive cardiomyopathy using mitral annular velocity by tissue Doppler echocardiography. Am J Cardiol. 2004;94:316–9.
Choi EY, Ha JW, Kim JM, et al. Incremental value of combining systolic mitral annular velocity and time difference between mitral inflow and diastolic mitral annular velocity to early diastolic annular velocity for differentiating constrictive pericarditis from restrictive cardiomyopathy. J Am Soc Echocardiogr. 2007;20:738–43.
Ha JW, Oh JK, Ling LH, Nishimura RA, Seward JB, Tajik AJ. Annulus paradoxus: transmitral flow velocity to mitral annular velocity ratio is inversely proportional to pulmonary capillary wedge pressure in patients with constrictive pericarditis. Circulation. 2001;104:976–8.
Reuss CS, Wilansky SM, Lester SJ, et al. Using mitral “annulus reversus” to diagnose constrictive pericarditis. Eur J Echocardiogr. 2009;10:372–5.
• Nagueh SF, Smiseth OA, Appleton CP, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29:277–314. The 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging recommendations for the evaluation of left ventricular diastolic function by echocardiography. This document provides a stepwise algorithm for differential diagnosis of constrictive pericarditis and restrictive cardiomyopathy.
• Yang JH, Miranda WR, Nishimura RA, Greason KL, Schaff HV, Oh JK. Prognostic importance of mitral e’ velocity in constrictive pericarditis. Eur Heart J Cardiovasc Imaging. 2021;22:357–64. A recent study describing prognostic value of mitral annular early diastolic velocity in patients with constrictive pericarditis.
Veress G, Ling LH, Kim KH, et al. Mitral and tricuspid annular velocities before and after pericardiectomy in patients with constrictive pericarditis. Circ Cardiovasc Imaging. 2011;4:399–407.
Klodas E, Nishimura RA, Appleton CP, Redfield MM, Oh JK. Doppler evaluation of patients with constrictive pericarditis: use of tricuspid regurgitation velocity curves to determine enhanced ventricular interaction. J Am Coll Cardiol. 1996;28:652–7.
Boonyaratavej S, Oh JK, Tajik AJ, Appleton CP, Seward JB. Comparison of mitral inflow and superior vena cava Doppler velocities in chronic obstructive pulmonary disease and constrictive pericarditis. J Am Coll Cardiol. 1998;32:2043–8.
• Madeira M, Teixeira R, Costa M, Goncalves L, Klein AL. Two-dimensional speckle tracking cardiac mechanics and constrictive pericarditis: systematic review. Echocardiography. 2016;33:1589–99. An excellent review article describing the role of speckle tracking echocardiography in the evaluation of constrictive pericarditis.
Negishi K, Popovic ZB, Negishi T, et al. Pericardiectomy is associated with improvement in longitudinal displacement of left ventricular free wall due to increased counterclockwise septal-to-lateral rotational displacement. J Am Soc Echocardiogr. 2015;28(1204–1213): e2.
Kusunose K, Dahiya A, Popovic ZB, et al. Biventricular mechanics in constrictive pericarditis comparison with restrictive cardiomyopathy and impact of pericardiectomy. Circ Cardiovasc Imaging. 2013;6:399–406.
Sengupta PP, Krishnamoorthy VK, Abhayaratna WP, et al. Disparate patterns of left ventricular mechanics differentiate constrictive pericarditis from restrictive cardiomyopathy. JACC Cardiovasc Imaging. 2008;1:29–38.
Bansal M, Mehrotra R, Kasliwal RR. Loss of left ventricular torsion as the predominant mechanism of left ventricular systolic dysfunction in a patient with tubercular cardiomyopathy. Echocardiography. 2012;29:E221–5.
Amaki M, Savino J, Ain DL, et al. Diagnostic concordance of echocardiography and cardiac magnetic resonance-based tissue tracking for differentiating constrictive pericarditis from restrictive cardiomyopathy. Circ Cardiovasc Imaging. 2014;7:819–27.
Stassen J, Jogani S, Schroyens M. Strain reversus revealing constrictive pericarditis. Eur Heart J Cardiovasc Imaging. 2021;22: e14.
Motoki H, Alraies MC, Dahiya A, et al. Changes in left atrial mechanics following pericardiectomy for pericardial constriction. J Am Soc Echocardiogr. 2013;26:640–8.
Liu S, Ma C, Ren W, et al. Regional left atrial function differentiation in patients with constrictive pericarditis and restrictive cardiomyopathy: a study using speckle tracking echocardiography. Int J Cardiovasc Imaging. 2015;31:1529–36.
Claus P, Omar AM, Pedrizzetti G, Sengupta PP, Nagel E. Tissue tracking technology for assessing cardiac mechanics: principles, normal values, and clinical applications. JACC Cardiovasc Imaging. 2015;8:1444–60.
Geyer H, Caracciolo G, Abe H et al. Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr 2010;23:351–69; quiz 453–5.
Phelan D, Collier P, Thavendiranathan P, et al. Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis. Heart. 2012;98:1442–8.
Baccouche H, Maunz M, Beck T, et al. Differentiating cardiac amyloidosis and hypertrophic cardiomyopathy by use of three-dimensional speckle tracking echocardiography. Echocardiography. 2012;29:668–77.
• Sato K, Ayache A, Kumar A, et al. Improvement in left ventricular mechanics following medical treatment of constrictive pericarditis. Heart. 2021;107:828–35. A recent study that described the role of strain imaging in monitoring response to anti-inflammatory therapy in patients with constrictive pericarditis.
Klein AL, Cohen GI, Pietrolungo JF, et al. Differentiation of constrictive pericarditis from restrictive cardiomyopathy by Doppler transesophageal echocardiographic measurements of respiratory variations in pulmonary venous flow. J Am Coll Cardiol. 1993;22:1935–43.
Sengupta PP, Huang YM, Bansal M et al. Cognitive machine-learning algorithm for cardiac imaging: a pilot study for differentiating constrictive pericarditis from restrictive cardiomyopathy. Circ Cardiovasc Imaging 2016;9.
Seetharam K, Shrestha S, Sengupta PP. Cardiovascular imaging and intervention through the lens of artificial intelligence. Interv Cardiol 2021;16:e31.
Bansal M, Sengupta PP. Restriction versus constriction. In Lang RM, Goldstein SA, Kronzon I, Khandheria B, Saric M, Mor-Avi V (Eds). ASE’s Comprehensive Echocardiography, 3rd ed, American Society of Echocardiography, Elsevier, USA, 2021, p 403.
Mahmoud A, Bansal M, Sengupta PP. New cardiac imaging algorithms to diagnose constrictive pericarditis versus restrictive cardiomyopathy. Curr Cardiol Rep 2017;19:43.
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Grewal, H.K., Bansal, M. Echocardiographic Differentiation of Pericardial Constriction and Left Ventricular Restriction. Curr Cardiol Rep 24, 1599–1610 (2022). https://doi.org/10.1007/s11886-022-01774-6
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DOI: https://doi.org/10.1007/s11886-022-01774-6