Abstract
Internet gaming disorder (IGD) is a subtype of internet addiction disorder (IAD), but its pathogenesis remains unclear. This study investigated brain function in IGD individuals using task-state functional magnetic resonance imaging (fMRI). It is a prospective study in 19 IGD individuals and 19 matched healthy controls. They all received internet videogame stimuli while a 3.0 T fMRI was used to assess echo planar imaging. Brain activity was analyzed using the Brain Voyager software package. Functional data were spatially smoothed using Gaussian kernel. The threshold level was positioned at 10 pixels, and the activation range threshold was set to 10 voxels. Activated brain regions were compared between the two groups, as well as the amount of activated voxels. The internet videogame stimuli activated brain regions in both groups. Compared with controls, the IGD group showed increased activation in the right superior parietal lobule, right insular lobe, right precuneus, right cingulated gyrus, right superior temporal gyrus, and left brainstem. There was a significant difference in the number of activated voxels between the two groups. An average of 1078 voxels was activated in the IGD group compared with only 232 in the control group. Internet videogame play activates the vision, space, attention, and execution centers located in the occipital, temporal, parietal, and frontal gyri. Abnormal brain function was noted in IGD subjects, with hypofunction of the frontal cortex. IGD subjects showed laterality activation of the right cerebral hemisphere.
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References
Baker T. E., & Holroyd C. B. (2011). Dissociated roles of the anterior cingulate cortex in reward and conflict processing as revealed by the feedback error-related negativity and N200. Biological Psychology, 87(1), 25–34. doi:10.1016/j.biopsycho.2011.01.010.
Beard K. W., & Wolf E. M. (2001). Modification in the proposed diagnostic criteria for Internet addiction. Cyberpsychology & Behavior, 4(3), 377–383.
Cao F., & Su L. (2007). Internet addiction among Chinese adolescents: prevalence and psychological features. Child: Care, Health and Development, 33(3), 275–281. doi:10.1111/j.1365-2214.2006.00715.x.
Chou C., & Hsiao M. C. (2000). Internet addiction, usage, gratification, and pleasure experience: the Taiwan college students’ case. Computers and Education, 35, 65–80.
Critchley H. D., Mathias C. J., Josephs O., O’Doherty J., Zanini S., Dewar B. K., Cipolotti L., Shallice T., & Dolan R. J. (2003). Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain : a journal of neurology, 126(Pt 10), 2139–2152. doi:10.1093/brain/awg216.
Ding W. N., Sun J. H., Sun Y. W., Chen X., Zhou Y., Zhuang Z. G., Li L., Zhang Y., Xu J. R., & Du Y. S. (2014). Trait impulsivity and impaired prefrontal impulse inhibition function in adolescents with internet gaming addiction revealed by a Go/No-Go fMRI study. Behavioral and brain functions : BBF, 10, 20. doi:10.1186/1744-9081-10-20.
Dong G., Zhou H., & Zhao X. (2011). Male Internet addicts show impaired executive control ability: evidence from a color-word Stroop task. Neuroscience Letters, 499(2), 114–118. doi:10.1016/j.neulet.2011.05.047.
Du W., Liu J., Gao X., Li L., Li W., Li X., Zhang Y., & Zhou S. (2011). Functional magnetic resonance imaging of brain of college students with internet addiction. Zhong nan da xue xue bao Yi xue ban = Journal of Central South University Medical sciences, 36(8), 744–749. doi:10.3969/j.issn.1672-7347.2011.08.008.
Ernst M., Matochik J. A., Heishman S. J., Van Horn J. D., Jons P. H., Henningfield J. E., & London E. D. (2001). Effect of nicotine on brain activation during performance of a working memory task. Proceedings of the National Academy of Sciences of the United States of America, 98(8), 4728–4733. doi:10.1073/pnas.061369098.
Goldstein R. Z., & Volkow N. D. (2011). Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nature Reviews Neuroscience, 12(11), 652–669. doi:10.1038/nrn3119.
Han D. H., Lyoo I. K., & Renshaw P. F. (2012). Differential regional gray matter volumes in patients with on-line game addiction and professional gamers. Journal of Psychiatric Research, 46(4), 507–515. doi:10.1016/j.jpsychires.2012.01.004.
Hong L. E., Gu H., Yang Y., Ross T. J., Salmeron B. J., Buchholz B., Thaker G. K., & Stein E. A. (2009). Association of nicotine addiction and nicotine’s actions with separate cingulate cortex functional circuits. Archives of General Psychiatry, 66(4), 431–441. doi:10.1001/archgenpsychiatry.2009.2.
Hutsler J., & Galuske R. A. (2003). Hemispheric asymmetries in cerebral cortical networks. Trends in Neurosciences, 26(8), 429–435. doi:10.1016/S0166-2236(03)00198-X.
Karnath H. O., Ferber S., & Himmelbach M. (2001). Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature, 411(6840), 950–953. doi:10.1038/35082075.
King D. L., Delfabbro P. H., Griffiths M. D., & Gradisar M. (2012). Cognitive-behavioral approaches to outpatient treatment of internet addiction in children and adolescents. Journal of Clinical Psychology, 68(11), 1185–1195. doi:10.1002/jclp.21918.
Ko C. H., Liu G. C., Hsiao S., Yen J. Y., Yang M. J., Lin W. C., Yen C. F., & Chen C. S. (2009). Brain activities associated with gaming urge of online gaming addiction. Journal of Psychiatric Research, 43(7), 739–747. doi:10.1016/j.jpsychires.2008.09.012.
Ko C. H., Liu G. C., Yen J. Y., Chen C. Y., Yen C. F., & Chen C. S. (2013). Brain correlates of craving for online gaming under cue exposure in subjects with Internet gaming addiction and in remitted subjects. Addiction Biology, 18(3), 559–569. doi:10.1111/j.1369-1600.2011.00405.x.
Kuss D. J. (2013). Internet gaming addiction: current perspectives. Psychology Research and Behavior Management, 6, 125–137. doi:10.2147/PRBM.S39476.
Kuss D. J., Louws J., & Wiers R. W. (2012). Online gaming addiction? Motives predict addictive play behavior in massively multiplayer online role-playing games. Cyberpsychology, Behavior and Social Networking, 15(9), 480–485. doi:10.1089/cyber.2012.0034.
Liu J., Gao X. P., Osunde I., Li X., Zhou S. K., Zheng H. R., & Li L. J. (2010). Increased regional homogeneity in internet addiction disorder: a resting state functional magnetic resonance imaging study. Chinese Medical Journal, 123(14), 1904–1908.
Liu J., Esmail F., Li L., Kou Z., Li W., Gao X., Wang Z., Tan C., Zhang Y., & Zhou S. (2013). Decreased frontal lobe function in people with Internet addiction disorder. Neural regeneration research, 8(34), 3225–3232. doi:10.3969/j.issn.1673-5374.2013.34.006.
Matyas F., Sreenivasan V., Marbach F., Wacongne C., Barsy B., Mateo C., Aronoff R., & Petersen C. C. (2010). Motor control by sensory cortex. Science, 330(6008), 1240–1243. doi:10.1126/science.1195797.
Mayberg H. S., Liotti M., Brannan S. K., McGinnis S., Mahurin R. K., Jerabek P. A., Silva J. A., Tekell J. L., Martin C. C., Lancaster J. L., & Fox P. T. (1999). Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. The American Journal of Psychiatry, 156(5), 675–682. doi:10.1176/ajp.156.5.675.
McCurdy L. Y., Maniscalco B., Metcalfe J., Liu K. Y., de Lange F. P., & Lau H. (2013). Anatomical coupling between distinct metacognitive systems for memory and visual perception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(5), 1897–1906. doi:10.1523/JNEUROSCI.1890-12.2013.
Menon V., & Uddin L. Q. (2010). Saliency, switching, attention and control: a network model of insula function. Brain Structure & Function, 214(5–6), 655–667. doi:10.1007/s00429-010-0262-0.
Rubia K., Smith A. B., Halari R., Matsukura F., Mohammad M., Taylor E., & Brammer M. J. (2009). Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention. The American Journal of Psychiatry, 166(1), 83–94. doi:10.1176/appi.ajp.2008.08020212.
Stoeckel M. C., Weder B., Binkofski F., Choi H. J., Amunts K., Pieperhoff P., Shah N. J., & Seitz R. J. (2004). Left and right superior parietal lobule in tactile object discrimination. The European Journal of Neuroscience, 19(4), 1067–1072.
Tremblay L., & Schultz W. (1999). Relative reward preference in primate orbitofrontal cortex. Nature, 398(6729), 704–708. doi:10.1038/19525.
Volkow N. D., Fowler J. S., & Wang G. J. (2003). The addicted human brain: insights from imaging studies. The Journal of Clinical Investigation, 111(10), 1444–1451. doi:10.1172/JCI18533.
Wolpert D. M., Goodbody S. J., & Husain M. (1998). Maintaining internal representations: the role of the human superior parietal lobe. Nature Neuroscience, 1(6), 529–533. doi:10.1038/2245.
World of Warcraft (2014) Wikipedia. (http://en.wikipedia.org/wiki/World_of_Warcraft). Accessed 10 Oct 2014.
Yuan K., Cheng P., Dong T., Bi Y., **ng L., Yu D., Zhao L., Dong M., von Deneen K. M., Liu Y., Qin W., & Tian J. (2013). Cortical thickness abnormalities in late adolescence with online gaming addiction. PloS One, 8(1), e53055. doi:10.1371/journal.pone.0053055.
Zang Y., Jiang T., Lu Y., He Y., & Tian L. (2004). Regional homogeneity approach to fMRI data analysis. NeuroImage, 22(1), 394–400. doi:10.1016/j.neuroimage.2003.12.030.
Acknowledgments
We wish to express our gratitude to all subjects who participated in this study, and to the funding agents: the National Natural Science Foundation of China (No. 30570695), the Development and Reform Commission of Hunan Province, the Natural Science Foundation of Hunan Province (No. 07JJ3042) and the Department of Public Health of Hunan Province (No. B2005048).
Conflict of interest
Jun Liu, Weihui Li, Shunke Zhou, Li Zhang, Zhiyuan Wang, Yan Zhang, Yebin Jiang and Lingjiang Li declare that they have no conflicts of interest.
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.
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Liu, J., Li, W., Zhou, S. et al. Functional characteristics of the brain in college students with internet gaming disorder . Brain Imaging and Behavior 10, 60–67 (2016). https://doi.org/10.1007/s11682-015-9364-x
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DOI: https://doi.org/10.1007/s11682-015-9364-x