Abstract
Objective
The aim of this study was to detect metastasis-associated in colon cancer-1 (MACC1) expression in Chinese gastric cancer and analyze the relationship between MACC1 expression and postoperative survival.
Methods
The expression of MACC1 and c-MET protein in a sample of 128 gastric cancer tissues was detected by immunohistochemistry. A retrospective cohort study on the prognosis was carried out and data were collected from medical records.
Results
The positive rate of MACC1 protein expression in gastric cancer was 47.66%, higher than that in adjacent noncancerous mucosa (P<0.001). MACC1 protein expression was not related to the clinicopathological variables involved. Kaplan-Meier analysis revealed that the survival of MACC1 positive group tended to be better than that of MACC1 negative group, particularly in patients with stage III carcinoma (P=0.032). Cox regression analysis revealed that MACC1 protein over-expression in gastric cancer tended to be a protective factor with hazard ratio of 0.621 (P=0.057). Immunohistochemical analysis showed that the positive rate of c-MET protein expression was much higher in cases with positive MACC1 expression in gastric cancer (P=0.002), but P53 expression was not associated with MACC1 expression.
Conclusion
MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients.
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This work was supported by the grants of the Foundation from Bei**g Municipal Committee of Science and Technology (No. D0905001040631), and the Scientific Research Foundation for the Returned Overseas Chinese Scholars from Ministry of Education of China.
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Ge, Sh., Wu, Xj., Wang, Xh. et al. Over-expression of metastasis-associated in colon cancer-1 (MACC1) associates with better prognosis of gastric cancer patients. Chin. J. Cancer Res. 23, 153–159 (2011). https://doi.org/10.1007/s11670-011-0153-9
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DOI: https://doi.org/10.1007/s11670-011-0153-9