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Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFα

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Summary

Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFα was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFα was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFα might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFα can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.

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Authors and Affiliations

  1. College of Life Science and Technology, Huazhong Universty of Science and Technology, Wuhan, 430074, China

    Liu **  (刘秀**)

  2. Molecular Targets Development Program, National Cancer Institute-Frederick National Institutes of Health Frederick, MD, 21702, USA

    **ong Changyun  (熊长云)

  3. Affiliated Tumor Hospital, Harbin Medical University, Harbin, 150030, China

    Li Chunhong  (**春红)

  4. College of Agriculture, Northeast Agricultural University, Harbin, 150030, China

    Yang Deguang  (杨德光)

Authors
  1. Liu **  (刘秀**)
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  2. **ong Changyun  (熊长云)
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  3. Li Chunhong  (**春红)
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  4. Yang Deguang  (杨德光)
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Additional information

LIU **, male, born in 1971, Ph.D.

This project was supported by a grant from NIH foundation of USA.

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Liu, X., **ong, C., Li, C. et al. Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFα. J. Huazhong Univ. Sc. Technol. 27, 354–357 (2007). https://doi.org/10.1007/s11596-007-0402-9

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  • DOI: https://doi.org/10.1007/s11596-007-0402-9

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