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A turn-on fluorescent probe for Au3+ based on rodamine derivative and its bioimaging application

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Abstract

A new fluorescent probe RY was synthesized for the detection of Au3+ ions based on a rhodamine B derivative. The fluorescent probe showed good selectivity and sensitivity to Au3+ ions. Obvious color and fluorescence changes could be observed with the naked eye while the fluorescent probe reacted with the Au3+ ions. The detection limit of the probe was determined to be 36 ppb by the fluorescence titration; the excellent linear relationship suggests that the probe is potentially useful for quantitative detection of Au3+ in vitro. We also demonstrated its bioimaging application in both living cells and mice; this was the first time that a fluorescent probe was successfully applied to imaging Au3+ in living animals.

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Authors and Affiliations

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China

    FengLing Song, HouFu Ning, HaiYing She & **aoJun Peng

  2. School of Life Science & Biotechnology, Dalian University of Technology, Dalian, 116024, China

    **gYun Wang

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  1. FengLing Song
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  2. HouFu Ning
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  3. HaiYing She
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  4. **gYun Wang
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  5. **aoJun Peng
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Correspondence to FengLing Song.

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Song, F., Ning, H., She, H. et al. A turn-on fluorescent probe for Au3+ based on rodamine derivative and its bioimaging application. Sci. China Chem. 57, 1043–1047 (2014). https://doi.org/10.1007/s11426-014-5107-x

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  • DOI: https://doi.org/10.1007/s11426-014-5107-x

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