Abstract
While mitochondria are susceptible to environmental detriments, little is known about potential associations between arsenic metabolites and mitochondria DNA copy number (mtDNAcn). We attempted to examine whether maternal urinary arsenic metabolite levels in different trimesters were related to neonatal cord blood mtDNAcn. We included 819 mother-newborn pairs embedded in an in-progress birth cohort survey performed from April 2014 to October 2016 in Wuhan, China. We determined maternal urinary arsenic species concentrations in different trimesters. We determined cord blood mtDNAcn using quantitative real-time polymerase chain reaction. In covariate-adjusted models, each one-unit increment of dimethylated arsenic (DMA) and total arsenic (TAs) in the third trimester was related to 8.43% (95% CI 1.13%, 16.26%) and 12.15% (95% CI 4.35%, 20.53%) increases in mtDNAcn, respectively. The dose–response trend with statistical significance was observed across tertiles of DMA and TAs in the third trimester with mtDNAcn (DMA percent changes (%Δ) = 25.60 (95% CI 6.73, 47.82), for the highest vs the lowest tertile (P = 0.02); TAs %Δ = 40.31 (95% CI 19.25, 65.10), for the highest vs the lowest tertile (P = 0.0002)). These findings may prove the relationships between prenatal arsenic species levels and neonatal mitochondrial dysfunction.
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The datasets analyzed during the current study are available from the corresponding author on reasonable request.
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The authors would like to acknowledge Shuangshuang Bao and ** this work.
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This work was supported by the National Natural Science Foundation of China (42077398), the Program for HUST Academic Frontier Youth Team (2018QYTD12), and the National Institutes of Health (R01ES029082).
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Feng Qiu: conceptualization, data curation, methodology, software, formal analysis, writing—original draft; Hongling Zhang: data curation, formal analysis; xin Wang: investigation, methodology; Zhenxian Jia: data curation, validation; Yujie He: investigation, methodology, validation; Yi Wu: investigation, methodology; Zhangpeng Li: data curation, investigation; Tongzhang Zheng: data curation, investigation. Wei **a: project administration, data curation, supervision. Shunqing Xu: conceptualization, project administration, resources; Yuanyuan Li: conceptualization, funding acquisition, project administration, writing—review and editing.
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Qiu, F., Zhang, H., Wang, X. et al. Prenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study. Environ Sci Pollut Res 31, 38142–38152 (2024). https://doi.org/10.1007/s11356-024-32933-7
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DOI: https://doi.org/10.1007/s11356-024-32933-7