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Incidence of postoperative cytomegalovirus and BK-polyoma virus infections and graft loss in ABO-incompatible renal transplant recipients: a multicenter retrospective study

  • Urology - Original Paper
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Abstract

Objectives

The current study aimed to examine the incidence of perioperative infections and graft viability in ABO-compatible and ABO-incompatible renal transplant recipients.

Methods

We included 643 living donor renal transplant recipients registered in the Michinoku Renal Transplant Network from 1998 to 2021. Patients were divided into the ABO-compatible and ABO-incompatible kidney transplantation groups. We compared the characteristics of the two groups and evaluated the incidence of postoperative viral infections (cytomegalovirus and BK virus), graft loss-free survival, and overall survival between the two groups.

Results

Of 643 patients, 485 (75%) and 158 (25%) were ABO-compatible and ABO-incompatible renal transplant recipients, respectively. Postoperative viral infections, rituximab use, and plasma exchange were significantly more common in ABO-incompatible than in ABO-compatible transplant recipients. However, there were no significant differences in terms of other background characteristics. The ABO-incompatible group was more likely to develop viral infections than the ABO-compatible group. Graft loss-free survival and overall survival did not significantly differ between the two groups. According to the multivariate Cox regression analysis, ABO compatibility was not significantly associated with graft loss-free survival and overall survival.

Conclusion

Although the incidence of postoperative viral infections in ABO-incompatible renal transplant recipients increased, there was no significant difference in terms of rejection events, graft loss-free survival, and overall survival.

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Data sharing and data accessibility

Data supporting the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to thank Yukie Nishizawa and Satomi Sakamoto for their invaluable support with data collection. The authors thank Enago (www.enago.jp) for their English language review.

Funding

This work was supported by the Japan Society for the Promotion of Science KAKENHI (grant numbers: 19H05556, 20K09517 and 20K18083) and the Japan Science and Technology Agency, Center of Innovation Program (grant number: JPMJCE1302).

Author information

Authors and Affiliations

  1. Department of Urology, Hirosaki University School of Medicine, 5 Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan

    Hirotake Kodama, Tomoko Hamaya & Chikara Ohyama

  2. Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, 5 Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan

    Shingo Hatakeyama

  3. Department of Urology, Iwate Medical University, 1-1-1 Idaidori, Yahaba-Cho, Shiwa-Gun, Morioka, Iwate, 028-3694, Japan

    Tomohiko Matsuura & Wataru Obara

  4. Department of Urology, Akita University School of Medicine, 1-1-1, Hondo, Akita, 010-8543, Japan

    Mitsuru Saito & Tomonori Habuchi

  5. Department of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan

    Hayato Nishida & Norihiko Tsuchiya

  6. Department of Urology, Iwate Prefectural Isawa Hospital, 61 Mizusawaryuugababa, Oshu, Iwate, 023-0864, Japan

    Shinya Maita

  7. Department of Cardiology and Nephrology, Hirosaki University School of Medicine, 5 Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan

    Reiichi Murakami & Hirofumi Tomita

  8. Department of Urology, Oyokyo Kidney Research Institute, 90 Kozawayamazaki, Hirosaki, Aomori, 036-8243, Japan

    Hisao Saitoh

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  1. Hirotake Kodama
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  2. Shingo Hatakeyama
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Contributions

HK, SH, HT, HS, NT, TH, WO, and CO developed and supervised the study. HK, SH, TM, MS, HN, TH, SM, and RM collected the study data. HK and SH performed the statistical analysis. HK and SH wrote the manuscript.

Corresponding author

Correspondence to Shingo Hatakeyama.

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Conflict of interest

The authors declare no conflicts of interest.

Approval of the research protocol by an institutional reviewer board

The current study was approved by the institutional review board (2014-015 and 2019-099-1).

Informed consent

All participants provided a written informed consent prior to study participation.

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Not available.

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Kodama, H., Hatakeyama, S., Matsuura, T. et al. Incidence of postoperative cytomegalovirus and BK-polyoma virus infections and graft loss in ABO-incompatible renal transplant recipients: a multicenter retrospective study. Int Urol Nephrol 56, 2187–2193 (2024). https://doi.org/10.1007/s11255-023-03934-1

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