SpringerLink
Log in

Three salicylaldehyde derivative Schiff base ZnII complexes: synthesis, DNA binding and hydroxyl radical scavenging capacity

  • Published:
Transition Metal Chemistry Aims and scope Submit manuscript

Abstract

Three new Schiff base ligands N-(3-formyl-5-methylsalicylidene)-2-aminoethanol (H2L1), N-(3-hydroxylmethyl-5-methylsalicylidene)-2-aminoethanol (H3L2), 2,6-bis(o-carboxyphenyliminomethene)-4-methylphenol (H3L3) and their binuclear ZnII complexes [Zn2(HL1)2]Cl2 · 2H2O (ZnHL1), [Zn2(H2L2)2]Cl2 · H2O (ZnH2L2) and [Zn2(HL3)Cl2] · H2O (ZnHL3) were synthesized and characterized by 1H-NMR, elemental analysis, IR and molar conductivity. The results suggest, in every case, two Zn2+ ions were bridged by phenolic OH group oxygen, forming a binuclear complex. The binding properties of these complexes to calf thymus DNA (ct-DNA) were investigated. Absorption and fluorescence spectra are together suggestive that both ZnHL1 and ZnHL3 interact with ct-DNA through intercalative mode, while ZnH2L2 interact with ct-DNA by non-intercalative interaction. Moreover, ZnHL3 can bind to ct-DNA more strongly than ZnHL1. These complexes also exhibited good scavenging activity on the hydroxyl radical (•OH), which are better than those of their corresponding ligands.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Erkkila K.E., Odom D.T. and Barton J.K. (1999). Chem. Rev. 99: 2777

    Article  CAS  Google Scholar 

  2. Ji L.N., Zhou X.H. and Liu J.G. (2001). Coord. Chem. Rev. 216–217: 513

    Article  Google Scholar 

  3. Zeng Z.Z. (2001). Synth. React. Inorg. Met.-Org. Nano-Met. Chem. 31: 1285

    Article  CAS  Google Scholar 

  4. Liu H. and Zeng Z.Z. (2005). Acta Chim. Sinica 63: 317

    CAS  Google Scholar 

  5. Zeng Z.Z. and **e X.M. (2000). Acta Chim. Sinica 58: 862

    CAS  Google Scholar 

  6. Arthur V. (1978). Textbook of practical organic chemistry, 4th edn., Longman Group Limited, London, 761

    Google Scholar 

  7. Marmur J. (1961). J. Mol. Biol. 3: 208

    Article  CAS  Google Scholar 

  8. Reichmann M.E., Rice S.A., Thomas C.A. and Doty P. (1954). J. Am. Chem. Soc. 76: 3047

    Article  CAS  Google Scholar 

  9. Wolfe A., Shimer G.H. and Meehan T. (1987). Biochemistry 26: 6392

    Article  CAS  Google Scholar 

  10. Winterbourn C.C. (1981). Biochem. J. 198: 125

    CAS  Google Scholar 

  11. Geary W.J. (1971). Coord. Chem. Rev. 7: 81

    Article  CAS  Google Scholar 

  12. Nakamoto K. (1986). Infrared and Raman Spectra of Inorganic and Coordination Compound, 4th edn., Wiley, New York, 231

    Google Scholar 

  13. J.Z. Wu, B.H. Ye, L. Wang, L.N. Ji, J.Y. Zhou, R.H. Li, Z.Y. Zhou, J. Chem. Soc., Dalton Trans., 1395 (1997)

  14. Y. **ong, X.F. He, X.H. Zou, J.Z. Wu, X.M. Chen, L.N. Ji, R.H. Li, J.Y. Zhou, K.B. Yu, J. Chem. Soc., Dalton Trans., 19 (1998)

  15. Pasternack R.F., Gibbs E.J. and Villafranca J.J. (1983). Biochemistry 22: 2406

    Article  CAS  Google Scholar 

  16. Liu J., Zhang T.X., Lu T.B., Qu L.H., Zhou H., Zhang Q.L. and Ji L.N. (2002). J. Inorg. Biochem. 91: 269

    Article  CAS  Google Scholar 

  17. Kelly J.M., McConnell D.J., OhUigin C., Tossi A.B., Mesmaeker A.K., Masschelein A. and Nasielski J. (1987). J. Chem. Soc. Chem. Commun. 24: 1821

    Article  Google Scholar 

  18. Zhang H.Y. (1999). Sci. China Ser. B 29: 91

    Google Scholar 

  19. Zhang L.W., Chen S.R. and Yang P. (2003). J. Struct. Chem. 22: 341

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P.R. China

    Hui-Li Lu, Jian-Jun Liang, Zheng-Zhi Zeng, Pin-**an **, **ao-Hui Liu, Feng-Juan Chen & Zhi-Hong Xu

Authors
  1. Hui-Li Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jian-Jun Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zheng-Zhi Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pin-**an **
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. **ao-Hui Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Feng-Juan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zhi-Hong Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zheng-Zhi Zeng.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lu, HL., Liang, JJ., Zeng, ZZ. et al. Three salicylaldehyde derivative Schiff base ZnII complexes: synthesis, DNA binding and hydroxyl radical scavenging capacity. Transition Met Chem 32, 564–569 (2007). https://doi.org/10.1007/s11243-007-0202-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11243-007-0202-x

Keywords

Search

Navigation