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Contact system activation in disseminated intravascular coagulation: activities of prekallikrein and high-molecular-weight kininogen are significant risk factors

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Abstract

The contact system activation can play a role in microthrombus formation of disseminated intravascular coagulation (DIC). This study investigated whether the activity of prekallikrein and high–molecular-weight kininogen (HMWK) correlated DIC progression. Contact system factors (prekallikrein, HMWK, activated factor XII), coagulation factors (IX, XI, XII) and tissue factor were measured in 140 patients who clinically suspected of having DIC. Prekallikrein and HMWK activity levels showed significant linear relationships with DIC score and antithrombin level, whereas prekallikrein and HMWK antigen levels did not. The activated factor XII, factor XII, factor XI and tissue factor were significant risk factors of overt-DIC. This finding suggests that consumption of prekallikrein and HMWK contributes to microvascular thrombosis in DIC. Measurements of prekallikrein and HMWK activity could be used as potential diagnostic markers for overt-DIC.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant (2021R1A2C1006302) funded by the Korea government (MSIT) and in part by Grant No. 04-2019-0300 from the SNUH Research Fund.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Sooyong Park, Ja-Yoon Gu & Hyun Kyung Kim

  2. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Ja-Yoon Gu & Hyun Kyung Kim

Authors
  1. Sooyong Park
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  2. Ja-Yoon Gu
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  3. Hyun Kyung Kim
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Contributions

HKK contributed to design the study and edit the manuscript. JYG contributed to perform the experiments and collect data. SYP contributed to data analysis and write the manuscript. All authors approved the final version for submission.

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Correspondence to Hyun Kyung Kim.

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All authors declare that they have no conflict of interest.

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The study was approved by the Institutional Review Board of Seoul National University Hospital and was conducted in accordance with the tenets of the Declaration of Helsinki.

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Park, S., Gu, JY. & Kim, H.K. Contact system activation in disseminated intravascular coagulation: activities of prekallikrein and high-molecular-weight kininogen are significant risk factors. J Thromb Thrombolysis 54, 11–14 (2022). https://doi.org/10.1007/s11239-021-02598-x

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  • DOI: https://doi.org/10.1007/s11239-021-02598-x

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