Abstract
A series of amino acid derivatives of oxalic acid were obtained. In combination therapy with conventional cytostatics used in lower doses, the new compounds substantially increase the efficacy of the drugs in the treatment of experimental P388 murine leukemia and some its drug-resistant strains.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
B. S. Fedorov, M. A. Fadeev, N. P. Konovalova, T. E. Sashenkova, M. V. Laryukova, S. M. Aldoshin, Pat. RF 2295517; Byul. Izobret. [Inventor Bull.], 2007, No. 8 (in Russian).
B. S. Fedorov, M. A. Fadeev, N. P. Konovalova, S. M. Aldoschin, T. E. Sashenkova, M. V. Larukova, Pat. Jpn 5249753, 2013.
B. S. Fedorov, M. A. Fadeev, A. B. Eremeev, N. P. Konovalova, G. N. Bogdanov, L. V. Tatyanenko, T. E. Sashenkova, D. V. Mishchenko, Russ. Chem. Bull., 2016, 65,801.
G. Housman, S. Byler, S. Heerboth, K. Lapinska, M. Longacre, N. Snyder, S. Sarkar, Cancer, 2014, 6, 1769–1792.
M. Mimeault, R. Hauke, S. K. Batra, Clinical Pharmacology Therapeutics, 2008, 83,673.
J. P. Gillet, M. M. Gottesman, Methods Mol. Biol., 2010, 596, 47–76.
M. Saraswathy, S. Gong, Biotechnol. Adv., 2013, 31, 1397–1407.
G. M. Sheldrik, SHELX-86, Program for the Crystal Structure Determination, University of Cambridge (England), 1986.
G. M. Sheldrick, SHELXTL v. 6.14, Structure Determination Software Suite, Bruker AXS, Madison (Wisconsin, USA), 2000.
Rukovodstvo po provedeniyu doklinicheskikh issledovanii lekarstvennykh sredstv [Manual on Preclinical Studies of Drugs], Part 1, Eds A. N. Mironov, N. D. Bunatyan, Moscow, 2012, 939 pp. (in Russian).
E. M. Treshchalina, O. S. Zhukova, G. K. Gerasimova, N. V. Andronova, A. M. Garin, Metodicheskie ukazaniya po izucheniyu protivoopukholevoi aktivnosti farmakologicheskikh ve shchestv [Methodological Guidelines for Study of Antitumor Activity of Pharmacological Agents] in Rukovodstvo po eks per imental´nomu (doklinicheskomu) izucheniyu novykh farmakolo gicheskikh veshchestv [Manual on Experimental (Preclinical) Study of New Pharma colo gical Substances], Meditsina, Moscow, 2005, 106 (in Russian).
Rukovodstvo po eksperimental´nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv [Manual on Experimental (Preclinical) Study of New Pharmacological Substances], Ed. R. U. Habriev, Meditsina, Moscow, 2005, 832 pp. (in Russian).
M. L. Belen´kii, Elementy kolichestvennoi otsenki farmakologicheskogo effekta [Elements of Quantitative Assessment of Pharmacological Effect], Gos. izd-vo med. lit-ry, Leningrad, 1963, 146 pp. (in Russian).
S. A. Goncharova, N. S. Demidova, O. A. Shiryaeva, V. N. Shevtsova, N. P. Konovalova, Eksperim. Onkologiya [Exp. Oncology], 1987, 9, 42–47 (in Russian).
N. S. Demidova, S. A. Goncharova, O. B. Chernova, B. P. Kopnin, A. V. Gudkov, Genetika [Soviet Genetics], 1987, 23, 1797–1806 (in Russian).
N. S. Demidova, O. B. Chernova, E. Y. Siyanova, S. A. Goncharova, B. P. Kopnin, Somatic Cell and Molecular Genetics, 1991, 17, 581–590.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0694–0699, April, 2018.
Deceased.
Rights and permissions
About this article
Cite this article
Fedorov, B.S., Goncharova, S.A., Rajevskaya, T.A. et al. Synthesis of oxalic acid derivatives and their antitumor activity in experiments in vivo. Russ Chem Bull 67, 694–699 (2018). https://doi.org/10.1007/s11172-018-2124-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11172-018-2124-5